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- W2761583418 abstract "Content: The increased oxidative stress in chronic obstructive pulmonary disease (COPD) patients is the result of increased inhaled oxidants, generated by various cells of the airways.Objective: The investigation included measurements of malondiadehyde (MDA), uric acid, ascorbic acid, and matrix metalloproteinase-12 (MMP-12) in COPD patient. We also performed genetic analysis for protein–protein interaction (PPI) network.Materials and methods: The study was conducted on healthy subjects with normal lung function (NS, 14 subjects) and 28 patients (Global Initiative for Chronic Obstructive Lung Disease (Gold) 1 and Gold 2) with COPD.Results: There was significant (p < .001) increase in MMP-12, MDA and uric acid levels as compared to healthy controls. A significant (p < .001) decline in ascorbic acid level was observed in COPD patients. The PPI was found to be 0.833 which indicated that proteins present in COPD are linked.Discussion and conclusion: This study suggests oxidative stress plays an important role in COPD and the PPI provide indication that proteins present in COPD are linked." @default.
- W2761583418 created "2017-10-20" @default.
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- W2761583418 date "2017-10-11" @default.
- W2761583418 modified "2023-10-18" @default.
- W2761583418 title "Biomarkers of oxidative stress and protein–protein interaction in chronic obstructive pulmonary disease" @default.
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- W2761583418 doi "https://doi.org/10.1080/13813455.2017.1387796" @default.
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