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- W2761641189 abstract "// Hui Wang 1 , Wenrong Xu 2 , Qixiang Shao 1 and Qing Ding 1 1 Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China 2 Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China Correspondence to: Qixiang Shao, email: shao_qx@ujs.edu.cn Qing Ding, email: qing_ding69@163.com Keywords: microRNA-21, interleukin-10, regulatory B cells, experimental autoimmune encephalomyelitis Received: June 29, 2017 Accepted: September 18, 2017 Published: October 06, 2017 ABSTRACT IL-10-producing regulatory B (IL-10 + Breg) cells promote tolerance in autoimmune diseases and transplantation. However, it remains unclear whether microRNAs are involved in the development of IL-10 + Breg cells. Here, we found that microRNA-21 (miR-21) acts as an upstream regulator of IL-10 by targeting the 3' untranslated region of IL-10 mRNA. We also demonstrated that IL-10 + Breg cells exhibit lower miR-21 expression than non-Breg cells and that miR-21 acts as a potent negative regulator of the differentiation of IL-10 + Breg cells. Accordingly, specific inhibition of miR-21 using antisense oligonucleotides markedly promoted B cell IL-10 expression. Thus, IL-10 is a direct target of miR-21. Moreover, silencing of miR-21 significantly alleviated the severity of experimental autoimmune encephalomyelitis (EAE), and this change was associated with an increase in the number of IL-10 + Breg cells. Finally, we demonstrated that miR-21-silenced B cells exert their suppressive activity through effector T cells in an IL-10-dependent manner. Thus, we characterized a B cell-intrinsic microRNA pathway that inhibits the differentiation of IL-10 + Breg cells and promotes autoimmunity. miR-21 silencing therefore represents a new therapeutic strategy for the treatment of autoimmune diseases." @default.
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- W2761641189 date "2017-10-06" @default.
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- W2761641189 title "miR-21 silencing ameliorates experimental autoimmune encephalomyelitis by promoting the differentiation of IL-10-producing B cells" @default.
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- W2761641189 doi "https://doi.org/10.18632/oncotarget.21578" @default.
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