FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761661531> ?p ?o ?g. }

• W2761661531 abstract "Abstract Toll-like receptor 4 (TLR4) plays a critical role in host immunity against Gram-negative bacteria. It transduces signals through two distinct TIR-domain-containing adaptors, MyD88 and TRIF, which function at the plasma membrane and endosomes, respectively. Using zebrafish Aeromonas hydrophila infection model, we demonstrate that synchronization of MyD88 and TRIF dependent pathways is critical for determining the fate of infection. Zebrafish were infected with A. hydrophila, and bacterial recovery studies suggested its effective persistence inside the host. Histopathological assessment elucidates that A. hydrophila did not provoke inflammatory responses in the spleen. Immunofluorescence revealed the presence of TLR4-bound A. hydrophila on the plasma membrane at 3 h post-infection (p.i.), and inside endosomes 1 day p.i. Quantitative PCR studies suggest that TLR4 activates the downstream pathway of MyD88–IRAK4 axis at early stages followed by a shift to TRIF–TRAF6 axis at late stages of infection coupled with fold increase in NF κ B. Our results implicated the involvement of p110 δ isoform of PI(3)Kinase in this transition. Coupled to this, we noted that the TLR4–TRIF–NF κ B axis prompted burgeoned secretion of anti-inflammatory cytokines. We observed that A. hydrophila inhibits endosome maturation and escapes to cytoplasm. Significant downregulation of cytosolic-NLR receptors further suggested that A. hydrophila represses pro-inflammatory responses in cytosol aiding its persistence. Our findings suggest a novel role of ‘TLR4 topology’ in A. hydrophila -induced pathogenesis. We propose that A. hydrophila manipulates translocation of TLR4 and migrates to endosome, where it triggers TRIF-dependent anti-inflammatory responses, interferes with endosomal maturation and escapes to cytosol. Inside the cytosol, A. hydrophila avoids detection by suppressing NLRs, facilitating its survival and ensuing pathogenesis." @default.
• W2761661531 created "2017-10-20" @default.
• W2761661531 creator A5017280088 @default.
• W2761661531 creator A5032395938 @default.
• W2761661531 creator A5040325054 @default.
• W2761661531 creator A5041445513 @default.
• W2761661531 creator A5060973746 @default.
• W2761661531 creator A5068812077 @default.
• W2761661531 creator A5072015746 @default.
• W2761661531 date "2017-10-02" @default.
• W2761661531 modified "2023-10-16" @default.
• W2761661531 title "Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish" @default.
• W2761661531 cites W1505229526 @default.
• W2761661531 cites W155910420 @default.
• W2761661531 cites W1924634855 @default.
• W2761661531 cites W1979813052 @default.
• W2761661531 cites W1981239255 @default.
• W2761661531 cites W1990484548 @default.
• W2761661531 cites W1998643282 @default.
• W2761661531 cites W1999604675 @default.
• W2761661531 cites W199999449 @default.
• W2761661531 cites W2003270818 @default.
• W2761661531 cites W2004194243 @default.
• W2761661531 cites W2004465286 @default.
• W2761661531 cites W2004773897 @default.
• W2761661531 cites W2010083224 @default.
• W2761661531 cites W2011509824 @default.
• W2761661531 cites W2015348280 @default.
• W2761661531 cites W2015665561 @default.
• W2761661531 cites W2022318593 @default.
• W2761661531 cites W2022474926 @default.
• W2761661531 cites W2026990267 @default.
• W2761661531 cites W2032783993 @default.
• W2761661531 cites W2038548285 @default.
• W2761661531 cites W2040112602 @default.
• W2761661531 cites W2042433863 @default.
• W2761661531 cites W2046864536 @default.
• W2761661531 cites W2048000602 @default.
• W2761661531 cites W2054735667 @default.
• W2761661531 cites W2057002887 @default.
• W2761661531 cites W2061100655 @default.
• W2761661531 cites W2067461984 @default.
• W2761661531 cites W2073382731 @default.
• W2761661531 cites W2084579544 @default.
• W2761661531 cites W2086213473 @default.
• W2761661531 cites W2087368694 @default.
• W2761661531 cites W2091324668 @default.
• W2761661531 cites W2097098907 @default.
• W2761661531 cites W2107373516 @default.
• W2761661531 cites W2111428445 @default.
• W2761661531 cites W2116428280 @default.
• W2761661531 cites W2118650779 @default.
• W2761661531 cites W2120101247 @default.
• W2761661531 cites W2121830340 @default.
• W2761661531 cites W2124413933 @default.
• W2761661531 cites W2131674777 @default.
• W2761661531 cites W2132822330 @default.
• W2761661531 cites W2135919238 @default.
• W2761661531 cites W2146316143 @default.
• W2761661531 cites W2146739467 @default.
• W2761661531 cites W2155706758 @default.
• W2761661531 cites W2156414024 @default.
• W2761661531 cites W2157339124 @default.
• W2761661531 cites W2160157717 @default.
• W2761661531 cites W2161100350 @default.
• W2761661531 cites W2171988343 @default.
• W2761661531 cites W2323625036 @default.
• W2761661531 cites W2404703480 @default.
• W2761661531 cites W2479739616 @default.
• W2761661531 cites W2565679751 @default.
• W2761661531 cites W2590763687 @default.
• W2761661531 cites W635454128 @default.
• W2761661531 cites W7379288 @default.
• W2761661531 doi "https://doi.org/10.1038/cddiscovery.2017.67" @default.
• W2761661531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5680545" @default.
• W2761661531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29142761" @default.
• W2761661531 hasPublicationYear "2017" @default.
• W2761661531 type Work @default.
• W2761661531 sameAs 2761661531 @default.
• W2761661531 citedByCount "25" @default.
• W2761661531 countsByYear W27616615312018 @default.
• W2761661531 countsByYear W27616615312019 @default.
• W2761661531 countsByYear W27616615312020 @default.
• W2761661531 countsByYear W27616615312021 @default.
• W2761661531 countsByYear W27616615312022 @default.
• W2761661531 countsByYear W27616615312023 @default.
• W2761661531 crossrefType "journal-article" @default.
• W2761661531 hasAuthorship W2761661531A5017280088 @default.
• W2761661531 hasAuthorship W2761661531A5032395938 @default.
• W2761661531 hasAuthorship W2761661531A5040325054 @default.
• W2761661531 hasAuthorship W2761661531A5041445513 @default.
• W2761661531 hasAuthorship W2761661531A5060973746 @default.
• W2761661531 hasAuthorship W2761661531A5068812077 @default.
• W2761661531 hasAuthorship W2761661531A5072015746 @default.
• W2761661531 hasBestOaLocation W27616615311 @default.
• W2761661531 hasConcept C102747710 @default.
• W2761661531 hasConcept C104317684 @default.
• W2761661531 hasConcept C136449434 @default.
• W2761661531 hasConcept C203014093 @default.
• W2761661531 hasConcept C2776070231 @default.

• next