Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761738384> ?p ?o ?g. }
- W2761738384 abstract "Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging. Pot1a is highly expressed in young HSCs, but declines with age. In mouse HSCs, Pot1a knockdown increases DNA damage response (DDR) and inhibits self-renewal. Conversely, Pot1a overexpression or treatment with POT1a protein prevents DDR, maintained self-renewal activity and rejuvenated aged HSCs upon ex vivo culture. Moreover, treatment of HSCs with exogenous Pot1a inhibits the production of reactive oxygen species, suggesting a non-telomeric role for Pot1a in HSC maintenance. Consistent with these results, treatment with exogenous human POT1 protein maintains human HSC activity in culture. Collectively, these results show that Pot1a/POT1 sustains HSC activity and can be used to expand HSC numbers ex vivo.Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species, and rejuvenated aged HSCs." @default.
- W2761738384 created "2017-10-20" @default.
- W2761738384 creator A5002869839 @default.
- W2761738384 creator A5004168381 @default.
- W2761738384 creator A5033896628 @default.
- W2761738384 creator A5034757003 @default.
- W2761738384 creator A5039347000 @default.
- W2761738384 creator A5042264497 @default.
- W2761738384 creator A5047305960 @default.
- W2761738384 creator A5054636847 @default.
- W2761738384 date "2017-10-06" @default.
- W2761738384 modified "2023-10-06" @default.
- W2761738384 title "The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age" @default.
- W2761738384 cites W1966891756 @default.
- W2761738384 cites W1972655555 @default.
- W2761738384 cites W1980052833 @default.
- W2761738384 cites W1982199027 @default.
- W2761738384 cites W1991327249 @default.
- W2761738384 cites W1993571663 @default.
- W2761738384 cites W1995091371 @default.
- W2761738384 cites W1996312428 @default.
- W2761738384 cites W1996435746 @default.
- W2761738384 cites W2001476942 @default.
- W2761738384 cites W2010847848 @default.
- W2761738384 cites W2017303317 @default.
- W2761738384 cites W2018139282 @default.
- W2761738384 cites W2021550815 @default.
- W2761738384 cites W2025067737 @default.
- W2761738384 cites W2028320710 @default.
- W2761738384 cites W2033766516 @default.
- W2761738384 cites W2036548019 @default.
- W2761738384 cites W2040568539 @default.
- W2761738384 cites W2041897873 @default.
- W2761738384 cites W2043740004 @default.
- W2761738384 cites W2049489460 @default.
- W2761738384 cites W2051565790 @default.
- W2761738384 cites W2058375396 @default.
- W2761738384 cites W2063062036 @default.
- W2761738384 cites W2068409711 @default.
- W2761738384 cites W2069781632 @default.
- W2761738384 cites W2074516296 @default.
- W2761738384 cites W2080032853 @default.
- W2761738384 cites W2081409454 @default.
- W2761738384 cites W2085387059 @default.
- W2761738384 cites W2088438660 @default.
- W2761738384 cites W2090569921 @default.
- W2761738384 cites W2092904031 @default.
- W2761738384 cites W2110565388 @default.
- W2761738384 cites W2120865735 @default.
- W2761738384 cites W2124242199 @default.
- W2761738384 cites W2125782175 @default.
- W2761738384 cites W2128536481 @default.
- W2761738384 cites W2130202974 @default.
- W2761738384 cites W2147765162 @default.
- W2761738384 cites W2148949291 @default.
- W2761738384 cites W2150490516 @default.
- W2761738384 cites W2150737519 @default.
- W2761738384 cites W2151955120 @default.
- W2761738384 cites W2154141161 @default.
- W2761738384 cites W2157144442 @default.
- W2761738384 cites W2160185049 @default.
- W2761738384 cites W2160538256 @default.
- W2761738384 cites W2167167418 @default.
- W2761738384 cites W2178620944 @default.
- W2761738384 doi "https://doi.org/10.1038/s41467-017-00935-4" @default.
- W2761738384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5630588" @default.
- W2761738384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28986560" @default.
- W2761738384 hasPublicationYear "2017" @default.
- W2761738384 type Work @default.
- W2761738384 sameAs 2761738384 @default.
- W2761738384 citedByCount "23" @default.
- W2761738384 countsByYear W27617383842018 @default.
- W2761738384 countsByYear W27617383842019 @default.
- W2761738384 countsByYear W27617383842020 @default.
- W2761738384 countsByYear W27617383842021 @default.
- W2761738384 crossrefType "journal-article" @default.
- W2761738384 hasAuthorship W2761738384A5002869839 @default.
- W2761738384 hasAuthorship W2761738384A5004168381 @default.
- W2761738384 hasAuthorship W2761738384A5033896628 @default.
- W2761738384 hasAuthorship W2761738384A5034757003 @default.
- W2761738384 hasAuthorship W2761738384A5039347000 @default.
- W2761738384 hasAuthorship W2761738384A5042264497 @default.
- W2761738384 hasAuthorship W2761738384A5047305960 @default.
- W2761738384 hasAuthorship W2761738384A5054636847 @default.
- W2761738384 hasBestOaLocation W27617383841 @default.
- W2761738384 hasConcept C104317684 @default.
- W2761738384 hasConcept C109159458 @default.
- W2761738384 hasConcept C143425029 @default.
- W2761738384 hasConcept C173396325 @default.
- W2761738384 hasConcept C177336024 @default.
- W2761738384 hasConcept C202265312 @default.
- W2761738384 hasConcept C207001950 @default.
- W2761738384 hasConcept C26291073 @default.
- W2761738384 hasConcept C2776879488 @default.
- W2761738384 hasConcept C2778086970 @default.
- W2761738384 hasConcept C28328180 @default.
- W2761738384 hasConcept C522857546 @default.
- W2761738384 hasConcept C54355233 @default.
- W2761738384 hasConcept C552990157 @default.
- W2761738384 hasConcept C81885089 @default.