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- W2761748022 endingPage "e0186415" @default.
- W2761748022 startingPage "e0186415" @default.
- W2761748022 abstract "The emergence of multidrug-resistant enterococci (MDRE) and particularly vancomycin-resistant enterococci (VRE) is considered a serious health problem worldwide, causing the need for new antimicrobials. The aim of this study was to discover and characterize bacteriocin against clinical isolates of MDRE and VRE. Over 10,000 bacterial isolates from water, environment and clinical samples were screened. E. faecalis strain 478 isolated from human feces produced the highest antibacterial activity against several MDRE and VRE strains. The optimum condition for bacteriocin production was cultivation in MRS broth at 37°C, pH 5–6 for 16 hours. The bacteriocin-like substance produced from E. faecalis strain EF478 was stable at 60°C for at least 1 hour and retained its antimicrobial activity after storage at -20°C for 1 year, at 4°C for 6 months, and at 25°C for 2 months. A nano-HPLC electrospray ionization multi-stage tandem mass spectrometry (nLC-ESI-MS/MS) analysis showed that the amino acid sequences of the bacteriocin-like substance was similar to serine protease of E. faecalis, gi|488296663 (NCBI database), which has never been reported as a bacteriocin. This study reported a novel bacteriocin with high antibacterial activity against VRE and MDRE." @default.
- W2761748022 created "2017-10-20" @default.
- W2761748022 creator A5006328173 @default.
- W2761748022 creator A5079795992 @default.
- W2761748022 creator A5083033825 @default.
- W2761748022 creator A5091183547 @default.
- W2761748022 date "2017-10-12" @default.
- W2761748022 modified "2023-10-03" @default.
- W2761748022 title "A novel bacteriocin from Enterococcus faecalis 478 exhibits a potent activity against vancomycin-resistant enterococci" @default.
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- W2761748022 doi "https://doi.org/10.1371/journal.pone.0186415" @default.