FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761760850> ?p ?o ?g. }

• W2761760850 abstract "While progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little is known regarding the corresponding T cell responses to ZIKV. Here, we investigate the kinetics and viral epitopes targeted by T cells responding to ZIKV and address the critical question of whether preexisting dengue virus (DENV) T cell immunity modulates these responses. We find that memory T cell responses elicited by prior infection with DENV or vaccination with tetravalent dengue attenuated vaccines (TDLAV) recognize ZIKV-derived peptides. This cross-reactivity is explained by the sequence similarity of the two viruses, as the ZIKV peptides recognized by DENV-elicited memory T cells are identical or highly conserved in DENV and ZIKV. DENV exposure prior to ZIKV infection also influences the timing and magnitude of the T cell response. ZIKV-reactive T cells in the acute phase of infection are detected earlier and in greater magnitude in DENV-immune patients. Conversely, the frequency of ZIKV-reactive T cells continues to rise in the convalescent phase in DENV-naive donors but declines in DENV-preexposed donors, compatible with more efficient control of ZIKV replication and/or clearance of ZIKV antigen. The quality of responses is also influenced by previous DENV exposure, and ZIKV-specific CD8 T cells from DENV-preexposed donors selectively upregulated granzyme B and PD1, unlike DENV-naive donors. Finally, we discovered that ZIKV structural proteins (E, prM, and C) are major targets of both the CD4 and CD8 T cell responses, whereas DENV T cell epitopes are found primarily in nonstructural proteins.IMPORTANCE The issue of potential ZIKV and DENV cross-reactivity and how preexisting DENV T cell immunity modulates Zika T cell responses is of great relevance, as the two viruses often cocirculate and Zika virus has been spreading in geographical regions where DENV is endemic or hyperendemic. Our data show that memory T cell responses elicited by prior infection with DENV recognize ZIKV-derived peptides and that DENV exposure prior to ZIKV infection influences the timing, magnitude, and quality of the T cell response. Additionally, we show that ZIKV-specific responses target different proteins than DENV-specific responses, pointing toward important implications for vaccine design against this global threat." @default.
• W2761760850 created "2017-10-20" @default.
• W2761760850 creator A5002024392 @default.
• W2761760850 creator A5004018725 @default.
• W2761760850 creator A5007870550 @default.
• W2761760850 creator A5008592726 @default.
• W2761760850 creator A5010966529 @default.
• W2761760850 creator A5014320685 @default.
• W2761760850 creator A5014657699 @default.
• W2761760850 creator A5021608465 @default.
• W2761760850 creator A5023547268 @default.
• W2761760850 creator A5025900296 @default.
• W2761760850 creator A5026694620 @default.
• W2761760850 creator A5027442064 @default.
• W2761760850 creator A5027463924 @default.
• W2761760850 creator A5030813412 @default.
• W2761760850 creator A5037285448 @default.
• W2761760850 creator A5039276250 @default.
• W2761760850 creator A5040983150 @default.
• W2761760850 creator A5043264155 @default.
• W2761760850 creator A5046971682 @default.
• W2761760850 creator A5050252136 @default.
• W2761760850 creator A5052433396 @default.
• W2761760850 creator A5054359071 @default.
• W2761760850 creator A5055761742 @default.
• W2761760850 creator A5062975649 @default.
• W2761760850 creator A5065157313 @default.
• W2761760850 creator A5070165631 @default.
• W2761760850 creator A5071188781 @default.
• W2761760850 creator A5071431150 @default.
• W2761760850 creator A5072484238 @default.
• W2761760850 creator A5077598738 @default.
• W2761760850 creator A5079820450 @default.
• W2761760850 creator A5080985934 @default.
• W2761760850 creator A5081739849 @default.
• W2761760850 creator A5081774281 @default.
• W2761760850 creator A5083515370 @default.
• W2761760850 creator A5083647614 @default.
• W2761760850 creator A5085447473 @default.
• W2761760850 creator A5086446779 @default.
• W2761760850 creator A5089599329 @default.
• W2761760850 creator A5090816940 @default.
• W2761760850 creator A5090825984 @default.
• W2761760850 date "2017-12-15" @default.
• W2761760850 modified "2023-10-14" @default.
• W2761760850 title "Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans" @default.
• W2761760850 cites W1590798843 @default.
• W2761760850 cites W1893326865 @default.
• W2761760850 cites W1966499706 @default.
• W2761760850 cites W1995636137 @default.
• W2761760850 cites W1996623895 @default.
• W2761760850 cites W1997966491 @default.
• W2761760850 cites W2007303291 @default.
• W2761760850 cites W2008597300 @default.
• W2761760850 cites W2019711015 @default.
• W2761760850 cites W2027894464 @default.
• W2761760850 cites W2039781676 @default.
• W2761760850 cites W2050324953 @default.
• W2761760850 cites W2081020320 @default.
• W2761760850 cites W2099694719 @default.
• W2761760850 cites W2119939554 @default.
• W2761760850 cites W2122349387 @default.
• W2761760850 cites W2128970995 @default.
• W2761760850 cites W2137879329 @default.
• W2761760850 cites W2141264905 @default.
• W2761760850 cites W2144505651 @default.
• W2761760850 cites W2145629676 @default.
• W2761760850 cites W2146980643 @default.
• W2761760850 cites W2151742317 @default.
• W2761760850 cites W2151777556 @default.
• W2761760850 cites W2152435786 @default.
• W2761760850 cites W2162252427 @default.
• W2761760850 cites W2169633859 @default.
• W2761760850 cites W2260741209 @default.
• W2761760850 cites W2263516683 @default.
• W2761760850 cites W2265557890 @default.
• W2761760850 cites W2272004514 @default.
• W2761760850 cites W2282391863 @default.
• W2761760850 cites W2285684471 @default.
• W2761760850 cites W2342696065 @default.
• W2761760850 cites W2411033015 @default.
• W2761760850 cites W2460107925 @default.
• W2761760850 cites W2464735068 @default.
• W2761760850 cites W2469258508 @default.
• W2761760850 cites W2470330280 @default.
• W2761760850 cites W2481866561 @default.
• W2761760850 cites W2485191472 @default.
• W2761760850 cites W2494098029 @default.
• W2761760850 cites W2515741006 @default.
• W2761760850 cites W2527567794 @default.
• W2761760850 cites W2528672224 @default.
• W2761760850 cites W2531376405 @default.
• W2761760850 cites W2538111061 @default.
• W2761760850 cites W2571101969 @default.
• W2761760850 cites W2594315729 @default.
• W2761760850 cites W2595707583 @default.
• W2761760850 cites W2600368028 @default.
• W2761760850 cites W2673196552 @default.
• W2761760850 cites W4210967474 @default.
• W2761760850 doi "https://doi.org/10.1128/jvi.01469-17" @default.

• next