Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761806141> ?p ?o ?g. }
- W2761806141 endingPage "62" @default.
- W2761806141 startingPage "51" @default.
- W2761806141 abstract "The Arc gene is robustly transcribed in specific neural ensembles in response to experience-driven activity. Upon induction, Arc mRNA is transported to dendrites, where it can be rapidly and locally translated by activation of metabotropic glutamate receptors (mGluR1/5). mGluR-induced dendritic synthesis of Arc is implicated in weakening or elimination of excitatory synapses by triggering endocytosis of postsynaptic AMPARs in both hippocampal CA1 and cerebellar Purkinje neurons. Importantly, CA1 neurons with experience-induced Arc mRNA are susceptible, or primed for mGluR-induced long-term synaptic depression (mGluR-LTD). Here we review mechanisms and function of Arc in mGluR-LTD and synapse elimination and propose roles for these forms of plasticity in Arc-dependent formation of sparse neural representations of learned experience. We also discuss accumulating evidence linking dysregulation of Arc and mGluR-LTD in human cognitive disorders such as intellectual disability, autism and Alzheimer's disease." @default.
- W2761806141 created "2017-10-20" @default.
- W2761806141 creator A5026272619 @default.
- W2761806141 creator A5038698200 @default.
- W2761806141 creator A5088427926 @default.
- W2761806141 date "2018-05-01" @default.
- W2761806141 modified "2023-10-17" @default.
- W2761806141 title "Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease" @default.
- W2761806141 cites W1440335865 @default.
- W2761806141 cites W1496673335 @default.
- W2761806141 cites W1519786933 @default.
- W2761806141 cites W1565087407 @default.
- W2761806141 cites W1573292604 @default.
- W2761806141 cites W1584279891 @default.
- W2761806141 cites W1592313435 @default.
- W2761806141 cites W1607671357 @default.
- W2761806141 cites W1863909522 @default.
- W2761806141 cites W1881736060 @default.
- W2761806141 cites W1892981381 @default.
- W2761806141 cites W1893201598 @default.
- W2761806141 cites W1967238741 @default.
- W2761806141 cites W1969769253 @default.
- W2761806141 cites W1969781703 @default.
- W2761806141 cites W1972633594 @default.
- W2761806141 cites W1975841935 @default.
- W2761806141 cites W1976666730 @default.
- W2761806141 cites W1976753789 @default.
- W2761806141 cites W1980004837 @default.
- W2761806141 cites W1981431290 @default.
- W2761806141 cites W1983059893 @default.
- W2761806141 cites W1983719168 @default.
- W2761806141 cites W1984881525 @default.
- W2761806141 cites W1985342948 @default.
- W2761806141 cites W1985489456 @default.
- W2761806141 cites W1986627859 @default.
- W2761806141 cites W1993719074 @default.
- W2761806141 cites W1995549311 @default.
- W2761806141 cites W1998571977 @default.
- W2761806141 cites W2001215117 @default.
- W2761806141 cites W2001900724 @default.
- W2761806141 cites W2002364516 @default.
- W2761806141 cites W2002617729 @default.
- W2761806141 cites W2002920547 @default.
- W2761806141 cites W2004784342 @default.
- W2761806141 cites W2005718392 @default.
- W2761806141 cites W2005943863 @default.
- W2761806141 cites W2007495000 @default.
- W2761806141 cites W2009126558 @default.
- W2761806141 cites W2009353293 @default.
- W2761806141 cites W2010939168 @default.
- W2761806141 cites W2011057165 @default.
- W2761806141 cites W2011182719 @default.
- W2761806141 cites W2011389660 @default.
- W2761806141 cites W2011876206 @default.
- W2761806141 cites W2013185658 @default.
- W2761806141 cites W2015084007 @default.
- W2761806141 cites W2017197221 @default.
- W2761806141 cites W2018457010 @default.
- W2761806141 cites W2018784755 @default.
- W2761806141 cites W2022138812 @default.
- W2761806141 cites W2022783417 @default.
- W2761806141 cites W2023353041 @default.
- W2761806141 cites W2023962370 @default.
- W2761806141 cites W2024386053 @default.
- W2761806141 cites W2024638612 @default.
- W2761806141 cites W2028569071 @default.
- W2761806141 cites W2028916975 @default.
- W2761806141 cites W2030040408 @default.
- W2761806141 cites W2030131218 @default.
- W2761806141 cites W2031177493 @default.
- W2761806141 cites W2031195859 @default.
- W2761806141 cites W2031785254 @default.
- W2761806141 cites W2033591860 @default.
- W2761806141 cites W2035664648 @default.
- W2761806141 cites W2035830949 @default.
- W2761806141 cites W2037497281 @default.
- W2761806141 cites W2040502865 @default.
- W2761806141 cites W2041562875 @default.
- W2761806141 cites W2043378710 @default.
- W2761806141 cites W2046390430 @default.
- W2761806141 cites W2047636274 @default.
- W2761806141 cites W2048581072 @default.
- W2761806141 cites W2051004265 @default.
- W2761806141 cites W2051692581 @default.
- W2761806141 cites W2052326665 @default.
- W2761806141 cites W2053950140 @default.
- W2761806141 cites W2054753187 @default.
- W2761806141 cites W2056491004 @default.
- W2761806141 cites W2056748460 @default.
- W2761806141 cites W2059208184 @default.
- W2761806141 cites W2061091689 @default.
- W2761806141 cites W2061342941 @default.
- W2761806141 cites W2063116040 @default.
- W2761806141 cites W2063370018 @default.
- W2761806141 cites W2063704147 @default.
- W2761806141 cites W2063798177 @default.
- W2761806141 cites W2064884011 @default.
- W2761806141 cites W2065380916 @default.