FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761851488> ?p ?o ?g. }

• W2761851488 abstract "Neutralizing antibodies (NAb) interfering with glycoprotein complex-mediated virus entry into host cells are thought to contribute to the protection against herpesvirus infection. However, using herpesvirus glycoprotein complexes as vaccine antigens can be complicated by the necessity of expressing multiple subunits simultaneously to allow efficient complex assembly and formation of conformational NAb epitopes. By using a novel bacterial artificial chromosome (BAC) clone of the clinically deployable Modified Vaccinia Ankara (MVA) vector and exploiting ribosomal skipping mediated by 2A peptides, MVA vectors were generated that expressed self-processing subunits of the human cytomegalovirus (HCMV) pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A. These MVA vectors expressed 2A-linked HCMV PC subunits that were efficiently cleaved and transported to the cell surface as protein complexes forming conformational neutralizing epitopes. In addition, vaccination of mice by only two immunizations with these MVA vectors resulted in potent HCMV NAb responses that remained stable over a period of at least six months. This method of eliciting NAb by 2A-linked, self-processing HCMV PC subunits could contribute to develop a HCMV vaccine candidate and may serve as a template to facilitate the development of subunit vaccine strategies against other herpesviruses." @default.
• W2761851488 created "2017-10-20" @default.
• W2761851488 creator A5012195686 @default.
• W2761851488 creator A5022693796 @default.
• W2761851488 creator A5036246350 @default.
• W2761851488 creator A5043325855 @default.
• W2761851488 creator A5054200483 @default.
• W2761851488 creator A5080946257 @default.
• W2761851488 creator A5087524048 @default.
• W2761851488 date "2018-01-01" @default.
• W2761851488 modified "2023-10-12" @default.
• W2761851488 title "Exploiting 2A peptides to elicit potent neutralizing antibodies by a multi-subunit herpesvirus glycoprotein complex" @default.
• W2761851488 cites W1479747867 @default.
• W2761851488 cites W1543119869 @default.
• W2761851488 cites W1604413850 @default.
• W2761851488 cites W1851333263 @default.
• W2761851488 cites W1864251807 @default.
• W2761851488 cites W1965971941 @default.
• W2761851488 cites W1971414812 @default.
• W2761851488 cites W1971742580 @default.
• W2761851488 cites W1973708619 @default.
• W2761851488 cites W1994882633 @default.
• W2761851488 cites W1999722506 @default.
• W2761851488 cites W2004176216 @default.
• W2761851488 cites W2015193281 @default.
• W2761851488 cites W2023545713 @default.
• W2761851488 cites W2023832375 @default.
• W2761851488 cites W2029345949 @default.
• W2761851488 cites W2031425216 @default.
• W2761851488 cites W2034632615 @default.
• W2761851488 cites W2038442395 @default.
• W2761851488 cites W2048935968 @default.
• W2761851488 cites W2065417495 @default.
• W2761851488 cites W2091115188 @default.
• W2761851488 cites W2093619247 @default.
• W2761851488 cites W2095651237 @default.
• W2761851488 cites W2096963698 @default.
• W2761851488 cites W2121315147 @default.
• W2761851488 cites W2126152550 @default.
• W2761851488 cites W2127258151 @default.
• W2761851488 cites W2128377922 @default.
• W2761851488 cites W2135356371 @default.
• W2761851488 cites W2153723315 @default.
• W2761851488 cites W2157752669 @default.
• W2761851488 cites W2261633018 @default.
• W2761851488 cites W2283825095 @default.
• W2761851488 cites W2409598223 @default.
• W2761851488 cites W2465813018 @default.
• W2761851488 cites W2539609404 @default.
• W2761851488 cites W2579318284 @default.
• W2761851488 cites W2615361789 @default.
• W2761851488 cites W2732927618 @default.
• W2761851488 cites W2734256369 @default.
• W2761851488 cites W4234941027 @default.
• W2761851488 cites W2746313368 @default.
• W2761851488 doi "https://doi.org/10.1016/j.jviromet.2017.10.006" @default.
• W2761851488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5682205" @default.
• W2761851488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28989096" @default.
• W2761851488 hasPublicationYear "2018" @default.
• W2761851488 type Work @default.
• W2761851488 sameAs 2761851488 @default.
• W2761851488 citedByCount "7" @default.
• W2761851488 countsByYear W27618514882017 @default.
• W2761851488 countsByYear W27618514882018 @default.
• W2761851488 countsByYear W27618514882019 @default.
• W2761851488 countsByYear W27618514882020 @default.
• W2761851488 crossrefType "journal-article" @default.
• W2761851488 hasAuthorship W2761851488A5012195686 @default.
• W2761851488 hasAuthorship W2761851488A5022693796 @default.
• W2761851488 hasAuthorship W2761851488A5036246350 @default.
• W2761851488 hasAuthorship W2761851488A5043325855 @default.
• W2761851488 hasAuthorship W2761851488A5054200483 @default.
• W2761851488 hasAuthorship W2761851488A5080946257 @default.
• W2761851488 hasAuthorship W2761851488A5087524048 @default.
• W2761851488 hasBestOaLocation W27618514882 @default.
• W2761851488 hasConcept C104292427 @default.
• W2761851488 hasConcept C104317684 @default.
• W2761851488 hasConcept C108625454 @default.
• W2761851488 hasConcept C147483822 @default.
• W2761851488 hasConcept C153911025 @default.
• W2761851488 hasConcept C159047783 @default.
• W2761851488 hasConcept C159654299 @default.
• W2761851488 hasConcept C195616568 @default.
• W2761851488 hasConcept C2522874641 @default.
• W2761851488 hasConcept C2777331810 @default.
• W2761851488 hasConcept C2779261636 @default.
• W2761851488 hasConcept C2779820661 @default.
• W2761851488 hasConcept C2781356689 @default.
• W2761851488 hasConcept C40767141 @default.
• W2761851488 hasConcept C54355233 @default.
• W2761851488 hasConcept C55493867 @default.
• W2761851488 hasConcept C86803240 @default.
• W2761851488 hasConceptScore W2761851488C104292427 @default.
• W2761851488 hasConceptScore W2761851488C104317684 @default.
• W2761851488 hasConceptScore W2761851488C108625454 @default.
• W2761851488 hasConceptScore W2761851488C147483822 @default.
• W2761851488 hasConceptScore W2761851488C153911025 @default.
• W2761851488 hasConceptScore W2761851488C159047783 @default.
• W2761851488 hasConceptScore W2761851488C159654299 @default.
• W2761851488 hasConceptScore W2761851488C195616568 @default.

• next