Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761920910> ?p ?o ?g. }
- W2761920910 abstract "Abstract Synergistic therapy that combines chemo‐, gene‐, or photothermal means shows great potential for enhancing the therapeutic effects on cancers. Tumor‐targeted nanoparticles based on a doxorubicin (DOX)‐gated mesoporous silica nanocore (MSN) encapsulated with permeability glycoprotein (P‐gp) small interfering RNA (siRNA) and a polydopamine (PDA) outer layer for DOX loading and folic acid decoration are designed. The multifunctional nanoplatform tactfully integrates chemo‐ (DOX), gene‐ (P‐gp siRNA), and photothermal (PDA layer) substances in one system. In vitro results reveal that DOX release behaviors are both pH‐ and thermal‐responsive and the release of co‐delivered P‐gp siRNA is also pH‐dependent due to the pH‐cleavable DOX gatekeeper on MSN. In addition, due to the near‐infrared light‐responsive PDA outer layer and folic acid conjugation, the nanoparticles exhibit outstanding photothermal activity and selective cell targeting ability. Subsequently, in vitro and in vivo antitumor experiments both demonstrate the enhanced antitumor efficacy of the multifunctional nanoparticles, indicating the significance of synergistic therapy combining chemo‐, gene‐, and photothermal treatments in one system." @default.
- W2761920910 created "2017-10-20" @default.
- W2761920910 creator A5025764843 @default.
- W2761920910 creator A5028397885 @default.
- W2761920910 creator A5030177789 @default.
- W2761920910 creator A5038617728 @default.
- W2761920910 creator A5047951924 @default.
- W2761920910 creator A5049379673 @default.
- W2761920910 creator A5050251296 @default.
- W2761920910 creator A5051411342 @default.
- W2761920910 creator A5053379226 @default.
- W2761920910 creator A5062964669 @default.
- W2761920910 date "2017-10-10" @default.
- W2761920910 modified "2023-10-16" @default.
- W2761920910 title "A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy" @default.
- W2761920910 cites W1549342368 @default.
- W2761920910 cites W1963526834 @default.
- W2761920910 cites W1978932462 @default.
- W2761920910 cites W1985241728 @default.
- W2761920910 cites W2000691433 @default.
- W2761920910 cites W2002779938 @default.
- W2761920910 cites W2004602103 @default.
- W2761920910 cites W2014497621 @default.
- W2761920910 cites W2017746519 @default.
- W2761920910 cites W2029989267 @default.
- W2761920910 cites W2055073285 @default.
- W2761920910 cites W2055776993 @default.
- W2761920910 cites W2055904567 @default.
- W2761920910 cites W2060887828 @default.
- W2761920910 cites W2065362813 @default.
- W2761920910 cites W2069124347 @default.
- W2761920910 cites W2075238581 @default.
- W2761920910 cites W2079929284 @default.
- W2761920910 cites W2080009168 @default.
- W2761920910 cites W2092858957 @default.
- W2761920910 cites W2131487381 @default.
- W2761920910 cites W2136277691 @default.
- W2761920910 cites W2140217618 @default.
- W2761920910 cites W2148491656 @default.
- W2761920910 cites W2152752812 @default.
- W2761920910 cites W2176599934 @default.
- W2761920910 cites W2177083746 @default.
- W2761920910 cites W2200565407 @default.
- W2761920910 cites W2288447976 @default.
- W2761920910 cites W2301441431 @default.
- W2761920910 cites W2314719402 @default.
- W2761920910 cites W2322562148 @default.
- W2761920910 cites W2335405043 @default.
- W2761920910 cites W2508405921 @default.
- W2761920910 cites W2511715507 @default.
- W2761920910 cites W2520550985 @default.
- W2761920910 cites W2547420156 @default.
- W2761920910 cites W2555167393 @default.
- W2761920910 cites W2560400314 @default.
- W2761920910 cites W2566222736 @default.
- W2761920910 cites W2570878808 @default.
- W2761920910 cites W2583475973 @default.
- W2761920910 cites W2586524855 @default.
- W2761920910 cites W2589168153 @default.
- W2761920910 cites W2590750118 @default.
- W2761920910 cites W2607204709 @default.
- W2761920910 cites W2613089336 @default.
- W2761920910 cites W2621849512 @default.
- W2761920910 cites W2742848079 @default.
- W2761920910 cites W53566393 @default.
- W2761920910 cites W646077703 @default.
- W2761920910 doi "https://doi.org/10.1002/adfm.201704135" @default.
- W2761920910 hasPublicationYear "2017" @default.
- W2761920910 type Work @default.
- W2761920910 sameAs 2761920910 @default.
- W2761920910 citedByCount "209" @default.
- W2761920910 countsByYear W27619209102017 @default.
- W2761920910 countsByYear W27619209102018 @default.
- W2761920910 countsByYear W27619209102019 @default.
- W2761920910 countsByYear W27619209102020 @default.
- W2761920910 countsByYear W27619209102021 @default.
- W2761920910 countsByYear W27619209102022 @default.
- W2761920910 countsByYear W27619209102023 @default.
- W2761920910 crossrefType "journal-article" @default.
- W2761920910 hasAuthorship W2761920910A5025764843 @default.
- W2761920910 hasAuthorship W2761920910A5028397885 @default.
- W2761920910 hasAuthorship W2761920910A5030177789 @default.
- W2761920910 hasAuthorship W2761920910A5038617728 @default.
- W2761920910 hasAuthorship W2761920910A5047951924 @default.
- W2761920910 hasAuthorship W2761920910A5049379673 @default.
- W2761920910 hasAuthorship W2761920910A5050251296 @default.
- W2761920910 hasAuthorship W2761920910A5051411342 @default.
- W2761920910 hasAuthorship W2761920910A5053379226 @default.
- W2761920910 hasAuthorship W2761920910A5062964669 @default.
- W2761920910 hasConcept C104317684 @default.
- W2761920910 hasConcept C111599444 @default.
- W2761920910 hasConcept C12554922 @default.
- W2761920910 hasConcept C150903083 @default.
- W2761920910 hasConcept C155672457 @default.
- W2761920910 hasConcept C161790260 @default.
- W2761920910 hasConcept C171250308 @default.
- W2761920910 hasConcept C182606246 @default.
- W2761920910 hasConcept C185592680 @default.
- W2761920910 hasConcept C192562407 @default.
- W2761920910 hasConcept C202751555 @default.