FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761987963> ?p ?o ?g. }

• W2761987963 endingPage "F914" @default.
• W2761987963 startingPage "F906" @default.
• W2761987963 abstract "Destabilized heme proteins release heme, and free heme is toxic. Heme is now recognized as an agonist for the Toll-like receptor-4 (TLR4) receptor. This study examined whether the TLR4 receptor mediates the nephrotoxicity of heme, specifically, the effects of heme on renal blood flow and inflammatory responses. We blocked TLR4 signaling by the specific antagonist TAK-242. Intravenous administration of heme to mice promptly reduced renal blood flow, an effect attenuated by TAK-242. In vitro, TAK-242 reduced heme-elicited activation of NF-κB and its downstream gene monocyte chemoattractant protein-1(MCP-1); in contrast, TAK-242 failed to reduce heme-induced activation of the anti-inflammatory transcription factor Nrf2 and its downstream gene heme oxygenase-1 (HO-1). TAK-242 did not reduce heme-induced renal MCP-1 upregulation in vivo. TAK-242 did not reduce dysfunction and histological injury in the glycerol model of heme protein-induced acute kidney injury (AKI), findings corroborated by studies in TLR4 +/+ and TLR4 −/− mice. We conclude that 1) acute heme-mediated renal vasoconstriction occurs through TLR4 signaling; 2) proinflammatory effects of heme in renal epithelial cells involve TLR4 signaling, whereas the anti-inflammatory effects of heme do not; 3) TLR4 signaling does not mediate the proinflammatory effects of heme in the kidney; and 4) major mechanisms underlying glycerol-induced, heme protein-mediated AKI do not involve TLR4 signaling. These findings in the glycerol model are in stark contrast with findings in virtually all other AKI models studied to date and emphasize the importance of TLR4-independent pathways of heme protein-mediated injury in this model. Finally, these studies urge caution when using observations derived in vitro to predict what occurs in vivo." @default.
• W2761987963 created "2017-10-20" @default.
• W2761987963 creator A5003968051 @default.
• W2761987963 creator A5034141505 @default.
• W2761987963 creator A5043649821 @default.
• W2761987963 creator A5056265052 @default.
• W2761987963 creator A5075670562 @default.
• W2761987963 creator A5082346434 @default.
• W2761987963 creator A5082575546 @default.
• W2761987963 creator A5088689412 @default.
• W2761987963 date "2018-05-01" @default.
• W2761987963 modified "2023-10-12" @default.
• W2761987963 title "Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins" @default.
• W2761987963 cites W1976091987 @default.
• W2761987963 cites W1981426346 @default.
• W2761987963 cites W1984887661 @default.
• W2761987963 cites W1988267071 @default.
• W2761987963 cites W2000860669 @default.
• W2761987963 cites W2005695657 @default.
• W2761987963 cites W2014870509 @default.
• W2761987963 cites W2018207514 @default.
• W2761987963 cites W2019712334 @default.
• W2761987963 cites W2028317647 @default.
• W2761987963 cites W2032959469 @default.
• W2761987963 cites W2039644178 @default.
• W2761987963 cites W2040990167 @default.
• W2761987963 cites W2042342255 @default.
• W2761987963 cites W2049406282 @default.
• W2761987963 cites W2051343325 @default.
• W2761987963 cites W2053189438 @default.
• W2761987963 cites W2055390072 @default.
• W2761987963 cites W2055659035 @default.
• W2761987963 cites W2056183344 @default.
• W2761987963 cites W2057467676 @default.
• W2761987963 cites W2060501523 @default.
• W2761987963 cites W2060676084 @default.
• W2761987963 cites W2060843217 @default.
• W2761987963 cites W2070256566 @default.
• W2761987963 cites W2076144892 @default.
• W2761987963 cites W2082863785 @default.
• W2761987963 cites W2083383675 @default.
• W2761987963 cites W2095931567 @default.
• W2761987963 cites W2099412572 @default.
• W2761987963 cites W2100360129 @default.
• W2761987963 cites W2104660347 @default.
• W2761987963 cites W2108352961 @default.
• W2761987963 cites W2115485369 @default.
• W2761987963 cites W2118360635 @default.
• W2761987963 cites W2125435505 @default.
• W2761987963 cites W2143461874 @default.
• W2761987963 cites W2144379673 @default.
• W2761987963 cites W2149396121 @default.
• W2761987963 cites W2166663693 @default.
• W2761987963 cites W2171043642 @default.
• W2761987963 cites W2508483050 @default.
• W2761987963 cites W2510642606 @default.
• W2761987963 cites W2549217003 @default.
• W2761987963 cites W2569292784 @default.
• W2761987963 cites W2582239943 @default.
• W2761987963 cites W2604429438 @default.
• W2761987963 doi "https://doi.org/10.1152/ajprenal.00432.2017" @default.
• W2761987963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6031913" @default.
• W2761987963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28978536" @default.
• W2761987963 hasPublicationYear "2018" @default.
• W2761987963 type Work @default.
• W2761987963 sameAs 2761987963 @default.
• W2761987963 citedByCount "30" @default.
• W2761987963 countsByYear W27619879632018 @default.
• W2761987963 countsByYear W27619879632019 @default.
• W2761987963 countsByYear W27619879632020 @default.
• W2761987963 countsByYear W27619879632021 @default.
• W2761987963 countsByYear W27619879632022 @default.
• W2761987963 countsByYear W27619879632023 @default.
• W2761987963 crossrefType "journal-article" @default.
• W2761987963 hasAuthorship W2761987963A5003968051 @default.
• W2761987963 hasAuthorship W2761987963A5034141505 @default.
• W2761987963 hasAuthorship W2761987963A5043649821 @default.
• W2761987963 hasAuthorship W2761987963A5056265052 @default.
• W2761987963 hasAuthorship W2761987963A5075670562 @default.
• W2761987963 hasAuthorship W2761987963A5082346434 @default.
• W2761987963 hasAuthorship W2761987963A5082575546 @default.
• W2761987963 hasAuthorship W2761987963A5088689412 @default.
• W2761987963 hasBestOaLocation W27619879631 @default.
• W2761987963 hasConcept C126189478 @default.
• W2761987963 hasConcept C126322002 @default.
• W2761987963 hasConcept C134018914 @default.
• W2761987963 hasConcept C164027704 @default.
• W2761987963 hasConcept C181199279 @default.
• W2761987963 hasConcept C185592680 @default.
• W2761987963 hasConcept C2776070231 @default.
• W2761987963 hasConcept C2776217839 @default.
• W2761987963 hasConcept C2776914184 @default.
• W2761987963 hasConcept C2779219270 @default.
• W2761987963 hasConcept C2780091579 @default.
• W2761987963 hasConcept C55493867 @default.
• W2761987963 hasConcept C62478195 @default.
• W2761987963 hasConcept C71924100 @default.
• W2761987963 hasConcept C86803240 @default.

• next