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- W2762019964 abstract "Abstract Several human population studies have sought to determine what components of the immune system confer protection to influenza infection. The aim of our study was to detect transcriptional changes contributing to the illness outcome in patients with naturally acquired influenza infection. Patients with naturally acquired influenza infection were recruited into a five year prospective, longitudinal cohort. Whole blood was sampled at day of enrollment (Day 0) and Days 3, 7, 10, and 28. Additionally, clinical data was collected during the course of infection including symptoms (upper respiratory, lower respiratory, systemic, and gastrointestinal symptoms). RNA was extracted from PBMCs collected at Day 0 in a subset of influenza infected patients (N=45) and was analyzed by RNA-Seq. Genes were ranked using Median Absolute Deviation (MAD) and then hierarchical clustering analysis was conducted using Spotfire and WGCNA. We detected two distinct clusters of individuals with large differences in their transcriptional landscapes falling into four clusters of genes. Principal components analysis was unable to define the clusters using any clinical traits including age, race, gender, and illness severity. One of the four clusters was characterized as an interferon response, where the other clusters have more complex annotations. Ongoing analyses are exploring upstream mechanisms that might lead to the observed divergent transcriptional outcomes." @default.
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- W2762019964 date "2015-05-01" @default.
- W2762019964 modified "2023-09-24" @default.
- W2762019964 title "Transcriptional landscape of immune responses to naturally acquired influenza (HUM6P.248)" @default.
- W2762019964 doi "https://doi.org/10.4049/jimmunol.194.supp.190.7" @default.
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