Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762020593> ?p ?o ?g. }
- W2762020593 endingPage "92756" @default.
- W2762020593 startingPage "92743" @default.
- W2762020593 abstract "Ovarian Cancer is the fifth leading cause of death among women from cancer. Cancer stem cells are a small population of cells present in cancer and the cause of chemoresistance and recurrence of cancer. We tested a new compound Verrucarin J (VJ), a metabolite of the Myrothecium fungus family, and showed that VJ significantly inhibits cell proliferation of both cisplatin-sensitive (A2780 and OVCAR5) and cisplatin-resistant (A2780/CP70) cell lines in a dose- and time-dependent manner with IC50 value of approximately 10 nM after 48 h of treatment. VJ was found to induce apoptosis, DNA damage, and generation of reactive oxygen species (ROS). Treatment of A2780 cells with VJ resulted in a significant suppression of expression of CSCs markers including ALDH1, LGR5, NANOG and OCT4 in a dose-dependent manner, elimination of ALDH1+ CSC population and inhibition of expression of Notch1 and Wnt1 signaling pathways. Our study also showed that VJ inhibited the tumorigenic potential (spheroid formation on ultralow attachment plates) of isolated ALDH1+ CSCs in vitro and tumor growth and metastasis in vivo. VJ resulted downregulation of expression of securin an oncogene involved in tumor growth and progression, indicating that securin may serve as a downstream signaling gene to mediate antitumor effects of VJ." @default.
- W2762020593 created "2017-10-20" @default.
- W2762020593 creator A5026756354 @default.
- W2762020593 creator A5070493069 @default.
- W2762020593 creator A5085147005 @default.
- W2762020593 creator A5087441184 @default.
- W2762020593 date "2017-10-06" @default.
- W2762020593 modified "2023-09-27" @default.
- W2762020593 title "Verrucarin J inhibits ovarian cancer and targets cancer stem cells" @default.
- W2762020593 cites W1590434810 @default.
- W2762020593 cites W1607210813 @default.
- W2762020593 cites W167005634 @default.
- W2762020593 cites W1964228070 @default.
- W2762020593 cites W1965912140 @default.
- W2762020593 cites W1968002492 @default.
- W2762020593 cites W1987805167 @default.
- W2762020593 cites W2008818697 @default.
- W2762020593 cites W2008934486 @default.
- W2762020593 cites W2009105270 @default.
- W2762020593 cites W2009211019 @default.
- W2762020593 cites W2009383305 @default.
- W2762020593 cites W2018360235 @default.
- W2762020593 cites W2030200135 @default.
- W2762020593 cites W2033366698 @default.
- W2762020593 cites W2037325146 @default.
- W2762020593 cites W2050212958 @default.
- W2762020593 cites W2052137378 @default.
- W2762020593 cites W2052872355 @default.
- W2762020593 cites W2062069198 @default.
- W2762020593 cites W2068325902 @default.
- W2762020593 cites W2086320165 @default.
- W2762020593 cites W2089818916 @default.
- W2762020593 cites W2091173796 @default.
- W2762020593 cites W2097585410 @default.
- W2762020593 cites W2099432930 @default.
- W2762020593 cites W2102085111 @default.
- W2762020593 cites W2105624032 @default.
- W2762020593 cites W2109152663 @default.
- W2762020593 cites W2118415907 @default.
- W2762020593 cites W2126712477 @default.
- W2762020593 cites W2129567747 @default.
- W2762020593 cites W2136388827 @default.
- W2762020593 cites W2143995836 @default.
- W2762020593 cites W2146074268 @default.
- W2762020593 cites W2147298899 @default.
- W2762020593 cites W2148125367 @default.
- W2762020593 cites W2155507705 @default.
- W2762020593 cites W2170086508 @default.
- W2762020593 cites W2179542136 @default.
- W2762020593 cites W2216963744 @default.
- W2762020593 cites W2290427823 @default.
- W2762020593 cites W2315159229 @default.
- W2762020593 cites W2318256082 @default.
- W2762020593 cites W2391015810 @default.
- W2762020593 cites W2528256323 @default.
- W2762020593 cites W2570618306 @default.
- W2762020593 cites W2743335538 @default.
- W2762020593 cites W4238780243 @default.
- W2762020593 doi "https://doi.org/10.18632/oncotarget.21574" @default.
- W2762020593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5696218" @default.
- W2762020593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29190952" @default.
- W2762020593 hasPublicationYear "2017" @default.
- W2762020593 type Work @default.
- W2762020593 sameAs 2762020593 @default.
- W2762020593 citedByCount "7" @default.
- W2762020593 countsByYear W27620205932017 @default.
- W2762020593 countsByYear W27620205932019 @default.
- W2762020593 countsByYear W27620205932020 @default.
- W2762020593 countsByYear W27620205932021 @default.
- W2762020593 countsByYear W27620205932023 @default.
- W2762020593 crossrefType "journal-article" @default.
- W2762020593 hasAuthorship W2762020593A5026756354 @default.
- W2762020593 hasAuthorship W2762020593A5070493069 @default.
- W2762020593 hasAuthorship W2762020593A5085147005 @default.
- W2762020593 hasAuthorship W2762020593A5087441184 @default.
- W2762020593 hasBestOaLocation W27620205931 @default.
- W2762020593 hasConcept C104317684 @default.
- W2762020593 hasConcept C107459253 @default.
- W2762020593 hasConcept C121608353 @default.
- W2762020593 hasConcept C127561419 @default.
- W2762020593 hasConcept C145103041 @default.
- W2762020593 hasConcept C185592680 @default.
- W2762020593 hasConcept C190283241 @default.
- W2762020593 hasConcept C207701140 @default.
- W2762020593 hasConcept C2776694085 @default.
- W2762020593 hasConcept C2778239845 @default.
- W2762020593 hasConcept C2780427987 @default.
- W2762020593 hasConcept C2781018059 @default.
- W2762020593 hasConcept C28328180 @default.
- W2762020593 hasConcept C2908647359 @default.
- W2762020593 hasConcept C29537977 @default.
- W2762020593 hasConcept C502942594 @default.
- W2762020593 hasConcept C53420372 @default.
- W2762020593 hasConcept C54355233 @default.
- W2762020593 hasConcept C55427017 @default.
- W2762020593 hasConcept C63378162 @default.
- W2762020593 hasConcept C71924100 @default.
- W2762020593 hasConcept C86803240 @default.