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• W2762101084 abstract "Different factors can influence the evolution of the mutation rate of a species: costs associated with DNA replication fidelity, indirect selection caused by the mutations produced (that should generally favor lower mutation rates, given that most mutations affecting fitness are deleterious), and genetic drift, which may render selection acting on weak mutators inefficient. In this paper, we use a two-locus model to compute the strength of indirect selection acting on a modifier locus that affects the mutation rate toward a deleterious allele at a second, linked, locus, in a population undergoing partial selfing or partial clonality. The results show that uniparental reproduction increases the effect of indirect selection for lower mutation rates. Extrapolating to the case of a whole genome with many deleterious alleles, and introducing a direct cost to DNA replication fidelity, the results can be used to compute the evolutionarily stable mutation rate, U In the absence of mutational bias toward higher U, the analytical prediction fits well with individual-based, multilocus simulation results. When such a bias is added into the simulations, however, genetic drift may lead to the maintenance of higher mutation rates, and this effect may be amplified in highly selfing or highly clonal populations due to their reduced effective population size." @default.
• W2762101084 created "2017-10-20" @default.
• W2762101084 creator A5010791324 @default.
• W2762101084 creator A5050855908 @default.
• W2762101084 date "2017-10-02" @default.
• W2762101084 modified "2023-10-12" @default.
• W2762101084 title "Mutation Rate Evolution in Partially Selfing and Partially Asexual Organisms" @default.
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• W2762101084 doi "https://doi.org/10.1534/genetics.117.300346" @default.
• W2762101084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5714466" @default.
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• W2762101084 hasPublicationYear "2017" @default.
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