FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762197986> ?p ?o ?g. }

• W2762197986 endingPage "e0186159" @default.
• W2762197986 startingPage "e0186159" @default.
• W2762197986 abstract "Most arthropods generate their posterior bodies by adding segments periodically, as the embryo grows, from a posteriorly located region called the segment addition zone. This mode of segmentation is shared with vertebrates and relies on oscillatory mechanisms, where the temporal periodicity of a clock is translated into repetitive spatial patterns. This ordered anterior-to-posterior pattern is achieved at the same time as the tissue elongates, opening the question of the functional coordination between the mechanisms of segmental patterning and posterior growth. The study of these processes in different arthropods has played an important role in unravelling some of the molecular mechanisms of segment formation. However, the behavior of cells during elongation and how cellular processes affect this segmental patterning has been poorly studied. Cell proliferation together with cell rearrangements are presumed to be the major forces driving axis elongation in the red flour beetle Tribolium castaneum. However, there still no strong evidence about the role and distribution of cell proliferation within the embryo. In this study, we propose to address these questions by using whole embryo cultures and pharmacological manipulation. We show that considerable cell proliferation occurs during germband elongation, measured by incorporation of the nucleoside analog of thymidine 5-Ethynyl-2'-deoxyuridine, EdU. Moreover, proliferating cells appeared to be spread along the elongating embryo with a posterior bias at early segmentation. In addition, when we blocked cell division, treated germbands were always shorter than controls and in some cases not able to fully elongate, even when control embryos already started to retract and leg buds are evident. Finally, we found that the absence of cell proliferation has no apparent effect on segmental patterning, as evidenced by Tc-engrailed (Tc-en) gene expression." @default.
• W2762197986 created "2017-10-20" @default.
• W2762197986 creator A5051426215 @default.
• W2762197986 creator A5055738928 @default.
• W2762197986 creator A5065286927 @default.
• W2762197986 creator A5087600682 @default.
• W2762197986 date "2017-10-09" @default.
• W2762197986 modified "2023-10-18" @default.
• W2762197986 title "Contribution of cell proliferation to axial elongation in the red flour beetle Tribolium castaneum" @default.
• W2762197986 cites W1879564354 @default.
• W2762197986 cites W1964750999 @default.
• W2762197986 cites W2000572318 @default.
• W2762197986 cites W2002150202 @default.
• W2762197986 cites W2016766507 @default.
• W2762197986 cites W2021583859 @default.
• W2762197986 cites W2027364030 @default.
• W2762197986 cites W2029669415 @default.
• W2762197986 cites W2031569719 @default.
• W2762197986 cites W2032406667 @default.
• W2762197986 cites W2033401579 @default.
• W2762197986 cites W2041791362 @default.
• W2762197986 cites W2064945767 @default.
• W2762197986 cites W2078229828 @default.
• W2762197986 cites W2085866853 @default.
• W2762197986 cites W2099878990 @default.
• W2762197986 cites W2102910500 @default.
• W2762197986 cites W2103272211 @default.
• W2762197986 cites W2106803522 @default.
• W2762197986 cites W2107907630 @default.
• W2762197986 cites W2126292167 @default.
• W2762197986 cites W2126704867 @default.
• W2762197986 cites W2131882884 @default.
• W2762197986 cites W2136439746 @default.
• W2762197986 cites W2143254725 @default.
• W2762197986 cites W2161925383 @default.
• W2762197986 cites W2165795986 @default.
• W2762197986 cites W2167415035 @default.
• W2762197986 cites W2169129330 @default.
• W2762197986 cites W2189480951 @default.
• W2762197986 cites W2227126098 @default.
• W2762197986 cites W2401667795 @default.
• W2762197986 cites W2470529548 @default.
• W2762197986 cites W2531024769 @default.
• W2762197986 cites W2606885223 @default.
• W2762197986 cites W4234359571 @default.
• W2762197986 cites W1570094459 @default.
• W2762197986 doi "https://doi.org/10.1371/journal.pone.0186159" @default.
• W2762197986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5633189" @default.
• W2762197986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29016664" @default.
• W2762197986 hasPublicationYear "2017" @default.
• W2762197986 type Work @default.
• W2762197986 sameAs 2762197986 @default.
• W2762197986 citedByCount "9" @default.
• W2762197986 countsByYear W27621979862018 @default.
• W2762197986 countsByYear W27621979862019 @default.
• W2762197986 countsByYear W27621979862020 @default.
• W2762197986 countsByYear W27621979862021 @default.
• W2762197986 crossrefType "journal-article" @default.
• W2762197986 hasAuthorship W2762197986A5051426215 @default.
• W2762197986 hasAuthorship W2762197986A5055738928 @default.
• W2762197986 hasAuthorship W2762197986A5065286927 @default.
• W2762197986 hasAuthorship W2762197986A5087600682 @default.
• W2762197986 hasBestOaLocation W27621979861 @default.
• W2762197986 hasConcept C105702510 @default.
• W2762197986 hasConcept C112950240 @default.
• W2762197986 hasConcept C12554922 @default.
• W2762197986 hasConcept C1491633281 @default.
• W2762197986 hasConcept C173758957 @default.
• W2762197986 hasConcept C183074962 @default.
• W2762197986 hasConcept C191897082 @default.
• W2762197986 hasConcept C192562407 @default.
• W2762197986 hasConcept C196843134 @default.
• W2762197986 hasConcept C2780554804 @default.
• W2762197986 hasConcept C33947775 @default.
• W2762197986 hasConcept C54355233 @default.
• W2762197986 hasConcept C59822182 @default.
• W2762197986 hasConcept C62112901 @default.
• W2762197986 hasConcept C85813293 @default.
• W2762197986 hasConcept C86803240 @default.
• W2762197986 hasConcept C95444343 @default.
• W2762197986 hasConceptScore W2762197986C105702510 @default.
• W2762197986 hasConceptScore W2762197986C112950240 @default.
• W2762197986 hasConceptScore W2762197986C12554922 @default.
• W2762197986 hasConceptScore W2762197986C1491633281 @default.
• W2762197986 hasConceptScore W2762197986C173758957 @default.
• W2762197986 hasConceptScore W2762197986C183074962 @default.
• W2762197986 hasConceptScore W2762197986C191897082 @default.
• W2762197986 hasConceptScore W2762197986C192562407 @default.
• W2762197986 hasConceptScore W2762197986C196843134 @default.
• W2762197986 hasConceptScore W2762197986C2780554804 @default.
• W2762197986 hasConceptScore W2762197986C33947775 @default.
• W2762197986 hasConceptScore W2762197986C54355233 @default.
• W2762197986 hasConceptScore W2762197986C59822182 @default.
• W2762197986 hasConceptScore W2762197986C62112901 @default.
• W2762197986 hasConceptScore W2762197986C85813293 @default.
• W2762197986 hasConceptScore W2762197986C86803240 @default.
• W2762197986 hasConceptScore W2762197986C95444343 @default.
• W2762197986 hasIssue "10" @default.

• next