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• W2762279441 abstract "3981 Although the efficiency of the mistletoe extract Iscador®P in the treatment of follicular B-Non-Hodgkin-Lymphoma (fB-NHL) concomitant with the benefit for the treated patients is well documented the usage of this extract is controversially discussed since former studies putatively indicated that (1) intravenous application of mistletoe extracts resulted in increased Interleukin-6 (IL-6) serum levels and that (2) mistletoe extracts itself may have a proliferatory influence on tumor cells. In order to rebut these points of view we investigated the influence of the mistletoe extract Iscador®P on defined fB-NHL cell lines (DoHH-2, WSU) in the presence of IL-6. All cell lines were seeded in duplicates and were incubated with clinically relevant doses of Iscador®P (1.5Âμg/ml - 15Âμg/ml/ 0.2x10^6 cells) in the presence of IL-6 for up to six days. Samples were taken every day to determine the cell number, to isolate mRNA for Bcl-2 and Bax quantification by RealTime-RT-PCR, and to determine the level of apoptotic cells by flow cytometry. All cell lines responded to IL-6 with an increased proliferation and/ or survival rate, which was efficiently blocked by Iscador®P. Similar results were achieved for IL-6 dependent multiple myeloma (MM) cell lines (RPMI 8226, TH-1). Quantitative analysis of the Bcl-2 and Bax gene expression in the WSU-NHL cell line by RealTime-RT-PCR revealed that the IL-6 induced Bcl-2 up-regulation is decreased by Iscador® P. In addition to this, long-term incubation with Iscador® P resulted in a shift from an anti-apoptotic towards a pro-apoptotic ratio of Bcl-2 and Bax concomitant with an increased number of apoptotic cells. These in-vitro data support the findings obtained from a prospective casuistics study, where 24 patients with follicular B-NHL were treated with Iscador® P and followed up over a period of 54 months. Remissions were triggered in 42% of those patients treated exclusively with mistletoe (4 complete remission (remission period (RP): 1.5 to 27.5 months), 6 partial remission (RP: 2.5 to 34 months), 1 minor remission (RP: 1 month). Disease progression was observed in 9 cases during monotherapy with Iscador®, although this was only temporary in some cases. Maintenance of remission, triggered by chemotherapy or surgery, was reached in 3 cases (2 complete remissions 18 and 20 months, respectively, 1 partial remission 10 months). During combined chemotherapy/mistletoe therapy, partial and complete remission were observed in 7 and 2 cases, respectively. The remission period ranged from 3 to 24 months. Disease progression occurred in 8 patients during this simultaneous therapy. In summary, our results clearly demonstrate the efficacy of mistletoe treatment in fB-NHLs." @default.
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• W2762279441 date "2005-05-01" @default.
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• W2762279441 title "The viscum album extract Iscador®P efficiently blocks the IL-6 dependent proliferation of B-non-hodgkin-lymphomas in-vitro and in-vivo" @default.
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