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- W2762375235 abstract "Recent years have seen substantially heightened interest in the discovery of tankyrase inhibitors (TNKSi) as new promising anticancer agents. In this framework, the aim of this review article is focused on the description of potent TNKSi also endowed with disruptor activity toward the Wnt/β-catenin signaling pathway. Beginning with an overview of the most characterized TNKSi deriving from several drug design approaches and classifying them on the basis of the molecular interactions with the target, we discuss only those ones acting against Wnt cancer cell lines. In addition, comprehensive structure property relationships (SPR) emerging from the hit evolution processes and preclinical results are provided. We then review the most promising TNKSi hitherto reported in literature, acting in vivo models of Wnt-driven cancers. Some outlooks on current issues and future directions in this field are also discussed." @default.
- W2762375235 created "2017-10-20" @default.
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- W2762375235 date "2017-12-01" @default.
- W2762375235 modified "2023-09-23" @default.
- W2762375235 title "Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors" @default.
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- W2762375235 doi "https://doi.org/10.1016/j.ejmech.2017.09.030" @default.
- W2762375235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29107427" @default.
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