Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762376970> ?p ?o ?g. }
- W2762376970 abstract "Objectives: Staphylococcus aureus infections in burn patients can lead to serious complications and death. The frequency of S. aureus infection is high in low- and middle-income countries presumably due to limited resources, misuse of antibiotics and poor infection control. The objective of the present study was to apply population genomics to precisely define, for the first time, the transmission of antibiotic resistant S. aureus in a resource-limited setting in sub-Saharan Africa. Methods: S. aureus surveillance was performed amongst burn patients and healthcare workers during a seven-months survey within the burn unit of the Korle Bu Teaching Hospital in Ghana. Results: 66 S. aureus isolates (59 colonizing and 7 clinical) were obtained from 31 patients and 10 healthcare workers. 21 of these isolates were ST250-IV methicillin-resistant S. aureus (MRSA). Notably, 25 (81%) of the 31 patients carried or were infected with S. aureus within 24 hours of admission. Genome comparisons revealed six distinct S. aureus clones circulating in the burn unit, and demonstrated multiple transmission events between patients and healthcare workers. Further, the collected S. aureus isolates exhibited a wide range of genotypic resistances to antibiotics, including trimethoprim (21%), aminoglycosides (33%), oxacillin (33%), chloramphenicol (50%), tetracycline (59%) and fluoroquinolones (100%). Conclusion: Population genomics uncovered multiple transmission events of S. aureus, especially MRSA, within the investigated burn unit. Our findings highlight lapses in infection control and prevention, and underscore the great importance of active surveillance to protect burn victims against multi-drug resistant pathogens in resource-limited settings." @default.
- W2762376970 created "2017-10-20" @default.
- W2762376970 creator A5007354016 @default.
- W2762376970 creator A5009056227 @default.
- W2762376970 creator A5011374851 @default.
- W2762376970 creator A5016350557 @default.
- W2762376970 creator A5017452242 @default.
- W2762376970 creator A5017481663 @default.
- W2762376970 creator A5028348105 @default.
- W2762376970 creator A5034601669 @default.
- W2762376970 creator A5044328561 @default.
- W2762376970 creator A5051406237 @default.
- W2762376970 creator A5058500554 @default.
- W2762376970 creator A5069674160 @default.
- W2762376970 creator A5070787254 @default.
- W2762376970 creator A5075796846 @default.
- W2762376970 creator A5087697755 @default.
- W2762376970 creator A5088404965 @default.
- W2762376970 date "2017-10-06" @default.
- W2762376970 modified "2023-10-01" @default.
- W2762376970 title "Methicillin Resistant Staphylococcus aureus Transmission in a Ghanaian Burn Unit: The Importance of Active Surveillance in Resource-Limited Settings" @default.
- W2762376970 cites W1512282207 @default.
- W2762376970 cites W1538375169 @default.
- W2762376970 cites W1583911428 @default.
- W2762376970 cites W1634330075 @default.
- W2762376970 cites W1642398994 @default.
- W2762376970 cites W1670675292 @default.
- W2762376970 cites W179648282 @default.
- W2762376970 cites W1822316797 @default.
- W2762376970 cites W1952618784 @default.
- W2762376970 cites W1964608103 @default.
- W2762376970 cites W1967064260 @default.
- W2762376970 cites W1971197474 @default.
- W2762376970 cites W1981691065 @default.
- W2762376970 cites W1983280804 @default.
- W2762376970 cites W1999699029 @default.
- W2762376970 cites W2013544574 @default.
- W2762376970 cites W2031611770 @default.
- W2762376970 cites W2034677156 @default.
- W2762376970 cites W2037198592 @default.
- W2762376970 cites W2039729207 @default.
- W2762376970 cites W2043733377 @default.
- W2762376970 cites W2050461582 @default.
- W2762376970 cites W2050831884 @default.
- W2762376970 cites W2064095352 @default.
- W2762376970 cites W2069584286 @default.
- W2762376970 cites W2071056263 @default.
- W2762376970 cites W2082117332 @default.
- W2762376970 cites W2087499871 @default.
- W2762376970 cites W2093453402 @default.
- W2762376970 cites W2099568096 @default.
- W2762376970 cites W2099928803 @default.
- W2762376970 cites W2102487784 @default.
- W2762376970 cites W2103952416 @default.
- W2762376970 cites W2106961803 @default.
- W2762376970 cites W2109952497 @default.
- W2762376970 cites W2110585775 @default.
- W2762376970 cites W2116279310 @default.
- W2762376970 cites W2120850876 @default.
- W2762376970 cites W2123243696 @default.
- W2762376970 cites W2129151411 @default.
- W2762376970 cites W2135776040 @default.
- W2762376970 cites W2144706728 @default.
- W2762376970 cites W2149567036 @default.
- W2762376970 cites W2159308620 @default.
- W2762376970 cites W2163263382 @default.
- W2762376970 cites W2164248238 @default.
- W2762376970 cites W2179445042 @default.
- W2762376970 cites W2253190072 @default.
- W2762376970 cites W2285843789 @default.
- W2762376970 cites W2472149962 @default.
- W2762376970 cites W2519731678 @default.
- W2762376970 cites W2577245948 @default.
- W2762376970 cites W2734613534 @default.
- W2762376970 cites W321778859 @default.
- W2762376970 cites W4233660663 @default.
- W2762376970 cites W85925740 @default.
- W2762376970 doi "https://doi.org/10.3389/fmicb.2017.01906" @default.
- W2762376970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5635451" @default.
- W2762376970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29056927" @default.
- W2762376970 hasPublicationYear "2017" @default.
- W2762376970 type Work @default.
- W2762376970 sameAs 2762376970 @default.
- W2762376970 citedByCount "10" @default.
- W2762376970 countsByYear W27623769702018 @default.
- W2762376970 countsByYear W27623769702019 @default.
- W2762376970 countsByYear W27623769702020 @default.
- W2762376970 countsByYear W27623769702021 @default.
- W2762376970 countsByYear W27623769702022 @default.
- W2762376970 crossrefType "journal-article" @default.
- W2762376970 hasAuthorship W2762376970A5007354016 @default.
- W2762376970 hasAuthorship W2762376970A5009056227 @default.
- W2762376970 hasAuthorship W2762376970A5011374851 @default.
- W2762376970 hasAuthorship W2762376970A5016350557 @default.
- W2762376970 hasAuthorship W2762376970A5017452242 @default.
- W2762376970 hasAuthorship W2762376970A5017481663 @default.
- W2762376970 hasAuthorship W2762376970A5028348105 @default.
- W2762376970 hasAuthorship W2762376970A5034601669 @default.
- W2762376970 hasAuthorship W2762376970A5044328561 @default.
- W2762376970 hasAuthorship W2762376970A5051406237 @default.