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• W2762465997 abstract "Abstract The Na + /H + exchanger of the plasma membrane of S. pombe ( Sp NHE1) removes intracellular sodium in exchange for an extracellular proton. We examined the structure and functional role of amino acids 360–393 of putative transmembrane (TM) segment XI of Sp NHE1. Structural analysis suggested that it had a helical propensity over amino acids 360–368, an extended region from 369–378 and was helical over amino acids 379–386. TM XI was sensitive to side chain alterations. Mutation of eight amino acids to alanine resulted in loss of one or both of LiCl or NaCl tolerance when re-introduced into Sp NHE1 deficient S. pombe . Mutation of seven other amino acids had minor effects. Analysis of structure and functional mutations suggested that Glu 361 may be involved in cation coordination on the cytoplasmic face of the protein with a negative charge in this position being important. His 367 , Ile 371 and Gly 372 were important in function. Ile 371 may have important hydrophobic interactions with other residues and Gly 372 may be important in maintaining an extended conformation. Several residues from Val 377 to Leu 384 are important in function possibly involved in hydrophobic interactions with other amino acids. We suggest that TM XI forms part of the ion translocation core of this Na + /H + exchanger." @default.
• W2762465997 created "2017-10-20" @default.
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• W2762465997 date "2017-10-16" @default.
• W2762465997 modified "2023-09-29" @default.
• W2762465997 title "Transmembrane Segment XI of the Na+/H+ Antiporter of S. pombe is a Critical Part of the Ion Translocation Pore" @default.
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• W2762465997 doi "https://doi.org/10.1038/s41598-017-12701-z" @default.
• W2762465997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5643542" @default.
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