FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762467259> ?p ?o ?g. }

• W2762467259 endingPage "139" @default.
• W2762467259 startingPage "133" @default.
• W2762467259 abstract "Summary We hypothesized that PRR contributes to renal inflammation in the 2‐kidney, 1‐clip (2K1C) renal ischaemia model. Male Sprague‐Dawley rats were fed normal sodium diet. Blood pressure ( BP ) was obtained on days 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%. Renal expression of TNF ‐α, COX ‐2, NF ‐κB, IL ‐1β, MCP ‐1 and collagen type I were assessed in sham and 2K1C rats with or without left renal administration of scramble or PRR sh RNA . At baseline, there were no differences in BP . Compared to sham, MAP significantly increased in clipped animals (sham 102 ± 1.9 vs 2K1C 131.8 ± 3.09 mmHg, P < .05) and was not influenced by scramble or PRR sh RNA treatment. Compared to sham and contra lateral (non‐clipped) kidney, there was upregulation in mRNA and protein expression of PRR (99% and 45%, P < .01), TNF ‐α (72% and 50%, P < .05), COX ‐2 (72% and 39%, P < .05), p‐ NF ‐κB (92%, P < .05), MCP ‐1 (87%, P < .05) and immunostaining of collagen type I in the clipped kidney. These increases were not influenced by scramble sh RNA . Compared to 2K1C and scramble sh RNA , PRR sh RNA treatment in the clipped kidney significantly reduced the expression of PRR (62% and 57%, P < .01), TNF ‐α (51% and 50%, P < .05), COX ‐2 (50% and 56%, P < .05), p‐ NF ‐κB by 68% ( P < .05), MCP ‐1 by 73% ( P < .05) and collagen type I respectively. Ang II was increased in both kidneys and did not change in response to scramble or PRR sh RNA treatments. We conclude that PRR mediates renal inflammation in renal ischaemia independent of blood pressure and Ang II ." @default.
• W2762467259 created "2017-10-20" @default.
• W2762467259 creator A5009083297 @default.
• W2762467259 creator A5030357833 @default.
• W2762467259 creator A5045403863 @default.
• W2762467259 date "2017-11-22" @default.
• W2762467259 modified "2023-10-14" @default.
• W2762467259 title "Prorenin receptor mediates inflammation in renal ischemia" @default.
• W2762467259 cites W1976070473 @default.
• W2762467259 cites W1981176441 @default.
• W2762467259 cites W2003284457 @default.
• W2762467259 cites W2024076076 @default.
• W2762467259 cites W2026702485 @default.
• W2762467259 cites W2027032451 @default.
• W2762467259 cites W2046388620 @default.
• W2762467259 cites W2047605577 @default.
• W2762467259 cites W2051665025 @default.
• W2762467259 cites W2054020448 @default.
• W2762467259 cites W2056031362 @default.
• W2762467259 cites W2073337699 @default.
• W2762467259 cites W2102806171 @default.
• W2762467259 cites W2107053866 @default.
• W2762467259 cites W2125174959 @default.
• W2762467259 cites W2128368934 @default.
• W2762467259 cites W2135439806 @default.
• W2762467259 cites W2138432059 @default.
• W2762467259 cites W2139181447 @default.
• W2762467259 cites W2148303421 @default.
• W2762467259 cites W2164431614 @default.
• W2762467259 cites W2167280899 @default.
• W2762467259 cites W2173952730 @default.
• W2762467259 cites W2187699488 @default.
• W2762467259 cites W2257523845 @default.
• W2762467259 cites W4252397535 @default.
• W2762467259 doi "https://doi.org/10.1111/1440-1681.12868" @default.
• W2762467259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5764787" @default.
• W2762467259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28980339" @default.
• W2762467259 hasPublicationYear "2017" @default.
• W2762467259 type Work @default.
• W2762467259 sameAs 2762467259 @default.
• W2762467259 citedByCount "10" @default.
• W2762467259 countsByYear W27624672592019 @default.
• W2762467259 countsByYear W27624672592020 @default.
• W2762467259 countsByYear W27624672592021 @default.
• W2762467259 countsByYear W27624672592023 @default.
• W2762467259 crossrefType "journal-article" @default.
• W2762467259 hasAuthorship W2762467259A5009083297 @default.
• W2762467259 hasAuthorship W2762467259A5030357833 @default.
• W2762467259 hasAuthorship W2762467259A5045403863 @default.
• W2762467259 hasBestOaLocation W27624672592 @default.
• W2762467259 hasConcept C104317684 @default.
• W2762467259 hasConcept C105580179 @default.
• W2762467259 hasConcept C126322002 @default.
• W2762467259 hasConcept C134018914 @default.
• W2762467259 hasConcept C170493617 @default.
• W2762467259 hasConcept C17991360 @default.
• W2762467259 hasConcept C185592680 @default.
• W2762467259 hasConcept C204232928 @default.
• W2762467259 hasConcept C2776914184 @default.
• W2762467259 hasConcept C2780091579 @default.
• W2762467259 hasConcept C2780114680 @default.
• W2762467259 hasConcept C2780721119 @default.
• W2762467259 hasConcept C4224716 @default.
• W2762467259 hasConcept C541997718 @default.
• W2762467259 hasConcept C55493867 @default.
• W2762467259 hasConcept C71924100 @default.
• W2762467259 hasConceptScore W2762467259C104317684 @default.
• W2762467259 hasConceptScore W2762467259C105580179 @default.
• W2762467259 hasConceptScore W2762467259C126322002 @default.
• W2762467259 hasConceptScore W2762467259C134018914 @default.
• W2762467259 hasConceptScore W2762467259C170493617 @default.
• W2762467259 hasConceptScore W2762467259C17991360 @default.
• W2762467259 hasConceptScore W2762467259C185592680 @default.
• W2762467259 hasConceptScore W2762467259C204232928 @default.
• W2762467259 hasConceptScore W2762467259C2776914184 @default.
• W2762467259 hasConceptScore W2762467259C2780091579 @default.
• W2762467259 hasConceptScore W2762467259C2780114680 @default.
• W2762467259 hasConceptScore W2762467259C2780721119 @default.
• W2762467259 hasConceptScore W2762467259C4224716 @default.
• W2762467259 hasConceptScore W2762467259C541997718 @default.
• W2762467259 hasConceptScore W2762467259C55493867 @default.
• W2762467259 hasConceptScore W2762467259C71924100 @default.
• W2762467259 hasFunder F4320332161 @default.
• W2762467259 hasIssue "2" @default.
• W2762467259 hasLocation W27624672591 @default.
• W2762467259 hasLocation W27624672592 @default.
• W2762467259 hasLocation W27624672593 @default.
• W2762467259 hasLocation W27624672594 @default.
• W2762467259 hasOpenAccess W2762467259 @default.
• W2762467259 hasPrimaryLocation W27624672591 @default.
• W2762467259 hasRelatedWork W2033472167 @default.
• W2762467259 hasRelatedWork W2034583712 @default.
• W2762467259 hasRelatedWork W2042033030 @default.
• W2762467259 hasRelatedWork W2056872482 @default.
• W2762467259 hasRelatedWork W2063619316 @default.
• W2762467259 hasRelatedWork W2127085070 @default.
• W2762467259 hasRelatedWork W2169225653 @default.
• W2762467259 hasRelatedWork W2361629841 @default.

• next