FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762546170> ?p ?o ?g. }

• W2762546170 endingPage "H94" @default.
• W2762546170 startingPage "H82" @default.
• W2762546170 abstract "In the diabetic heart, there is excessive dependence on fatty acid (FA) utilization to generate ATP. Lipoprotein lipase (LPL)-mediated hydrolysis of circulating triglycerides is suggested to be the predominant source of FA for cardiac utilization during diabetes. In the heart, the majority of LPL is synthesized in cardiomyocytes and secreted onto cell surface heparan sulfate proteoglycan (HSPG), where an endothelial cell (EC)-releasable β-endoglycosidase, heparanase cleaves the side chains of HSPG to liberate LPL for its onward movement across the EC. EC glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) captures this released enzyme at its basolateral side and shuttles it across to its luminal side. We tested whether the diabetes-induced increase of transforming growth factor-β (TGF-β) can influence the myocyte and EC to help transfer LPL to the vascular lumen to generate triglyceride-FA. In response to high glucose and EC heparanase secretion, this endoglycosidase is taken up by the cardiomyocyte (Wang Y, Chiu AP, Neumaier K, Wang F, Zhang D, Hussein B, Lal N, Wan A, Liu G, Vlodavsky I, Rodrigues B. Diabetes 63: 2643–2655, 2014) to stimulate matrix metalloproteinase-9 expression and the conversion of latent to active TGF-β. In the cardiomyocyte, TGF-β activation of RhoA enhances actin cytoskeleton rearrangement to promote LPL trafficking and secretion onto cell surface HSPG. In the EC, TGF-β signaling promotes mesodermal homeobox 2 translocation to the nucleus, which increases the expression of GPIHBP1, which facilitates movement of LPL to the vascular lumen. Collectively, our data suggest that in the diabetic heart, TGF-β actions on the cardiomyocyte promotes movement of LPL, whereas its action on the EC facilitates LPL shuttling. NEW & NOTEWORTHY Endothelial cells, as first responders to hyperglycemia, release heparanase, whose subsequent uptake by cardiomyocytes amplifies matrix metalloproteinase-9 expression and activation of transforming growth factor-β. Transforming growth factor-β increases lipoprotein lipase secretion from cardiomyocytes and promotes mesodermal homeobox 2 to enhance glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1-dependent transfer of lipoprotein lipase across endothelial cells, mechanisms that accelerate fatty acid utilization by the diabetic heart." @default.
• W2762546170 created "2017-10-20" @default.
• W2762546170 creator A5002208693 @default.
• W2762546170 creator A5008981001 @default.
• W2762546170 creator A5010424073 @default.
• W2762546170 creator A5037824025 @default.
• W2762546170 creator A5056631703 @default.
• W2762546170 creator A5061683350 @default.
• W2762546170 creator A5064727905 @default.
• W2762546170 creator A5084471231 @default.
• W2762546170 date "2018-01-01" @default.
• W2762546170 modified "2023-10-02" @default.
• W2762546170 title "Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity" @default.
• W2762546170 cites W119322828 @default.
• W2762546170 cites W1487581481 @default.
• W2762546170 cites W1524089950 @default.
• W2762546170 cites W1575754639 @default.
• W2762546170 cites W1931073059 @default.
• W2762546170 cites W1952404770 @default.
• W2762546170 cites W1972913443 @default.
• W2762546170 cites W1974801728 @default.
• W2762546170 cites W1974812715 @default.
• W2762546170 cites W1975446311 @default.
• W2762546170 cites W1976840082 @default.
• W2762546170 cites W1980780108 @default.
• W2762546170 cites W1982086167 @default.
• W2762546170 cites W1985400766 @default.
• W2762546170 cites W1993057072 @default.
• W2762546170 cites W1993531220 @default.
• W2762546170 cites W1994889733 @default.
• W2762546170 cites W1995150742 @default.
• W2762546170 cites W1996427377 @default.
• W2762546170 cites W2002621910 @default.
• W2762546170 cites W2006301175 @default.
• W2762546170 cites W2006786223 @default.
• W2762546170 cites W2019274593 @default.
• W2762546170 cites W2025396422 @default.
• W2762546170 cites W2035909642 @default.
• W2762546170 cites W2038859492 @default.
• W2762546170 cites W2041172831 @default.
• W2762546170 cites W2045956313 @default.
• W2762546170 cites W2048380324 @default.
• W2762546170 cites W2053580623 @default.
• W2762546170 cites W2054526193 @default.
• W2762546170 cites W2054649531 @default.
• W2762546170 cites W2055061339 @default.
• W2762546170 cites W2059104750 @default.
• W2762546170 cites W2060734951 @default.
• W2762546170 cites W2069315162 @default.
• W2762546170 cites W2075027229 @default.
• W2762546170 cites W2075635876 @default.
• W2762546170 cites W2085433847 @default.
• W2762546170 cites W2086833378 @default.
• W2762546170 cites W2092869660 @default.
• W2762546170 cites W2098437467 @default.
• W2762546170 cites W2098643301 @default.
• W2762546170 cites W2105301755 @default.
• W2762546170 cites W2106389977 @default.
• W2762546170 cites W2107359871 @default.
• W2762546170 cites W2107434078 @default.
• W2762546170 cites W2113313714 @default.
• W2762546170 cites W2113531489 @default.
• W2762546170 cites W2115118514 @default.
• W2762546170 cites W2128606426 @default.
• W2762546170 cites W2131578695 @default.
• W2762546170 cites W2132243176 @default.
• W2762546170 cites W2132896657 @default.
• W2762546170 cites W2133521971 @default.
• W2762546170 cites W2139165347 @default.
• W2762546170 cites W2141306324 @default.
• W2762546170 cites W2143314569 @default.
• W2762546170 cites W2149522649 @default.
• W2762546170 cites W2150313131 @default.
• W2762546170 cites W2152595924 @default.
• W2762546170 cites W2153590662 @default.
• W2762546170 cites W2154326493 @default.
• W2762546170 cites W2154803476 @default.
• W2762546170 cites W2157297915 @default.
• W2762546170 cites W2158075365 @default.
• W2762546170 cites W2161773048 @default.
• W2762546170 cites W2163785113 @default.
• W2762546170 cites W2165256339 @default.
• W2762546170 cites W2166277864 @default.
• W2762546170 cites W2167083760 @default.
• W2762546170 cites W2174724706 @default.
• W2762546170 cites W2547035012 @default.
• W2762546170 cites W2560987280 @default.
• W2762546170 cites W4249578387 @default.
• W2762546170 cites W4253244719 @default.
• W2762546170 cites W4294352168 @default.
• W2762546170 doi "https://doi.org/10.1152/ajpheart.00372.2017" @default.
• W2762546170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28986359" @default.
• W2762546170 hasPublicationYear "2018" @default.
• W2762546170 type Work @default.
• W2762546170 sameAs 2762546170 @default.
• W2762546170 citedByCount "11" @default.
• W2762546170 countsByYear W27625461702018 @default.
• W2762546170 countsByYear W27625461702019 @default.

• next