FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762584480> ?p ?o ?g. }

• W2762584480 endingPage "L205" @default.
• W2762584480 startingPage "L192" @default.
• W2762584480 abstract "In cystic fibrosis (CF) lungs, epithelial Na + channel (ENaC) hyperactivity causes a reduction in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection, and lung damage. Inhibition of ENaC is an attractive therapeutic option. However, ENaC antagonists have failed clinically because of off-target effects in the kidney. The S18 peptide is a naturally occurring short palate lung and nasal epithelial clone 1 (SPLUNC1)-derived ENaC antagonist that restores airway surface liquid height for up to 24 h in CF human bronchial epithelial cultures. However, its efficacy and safety in vivo are unknown. To interrogate the potential clinical efficacy of S18, we assessed its safety and efficacy using human airway cultures and animal models. S18-mucus interactions were tested using superresolution microscopy, quartz crystal microbalance with dissipation, and confocal microscopy. Human and murine airway cultures were used to measure airway surface liquid height. Off-target effects were assessed in conscious mice and anesthetized rats. Morbidity and mortality were assessed in the β-ENaC-transgenic (Tg) mouse model. Restoration of normal mucus clearance was measured in cystic fibrosis transmembrane conductance regulator inhibitor 172 [CFTR(inh)-172]-challenged sheep. We found that S18 does not interact with mucus and rapidly penetrated dehydrated CF mucus. Compared with amiloride, an early generation ENaC antagonist, S18 displayed a superior ability to slow airway surface liquid absorption, reverse CFTR(inh)-172-induced reduction of mucus transport, and reduce morbidity and mortality in the β-ENaC-Tg mouse, all without inducing any detectable signs of renal toxicity. These data suggest that S18 is the first naturally occurring ENaC antagonist to show improved preclinical efficacy in animal models of CF with no signs of renal toxicity." @default.
• W2762584480 created "2017-10-20" @default.
• W2762584480 creator A5001272649 @default.
• W2762584480 creator A5002268777 @default.
• W2762584480 creator A5010493469 @default.
• W2762584480 creator A5012677805 @default.
• W2762584480 creator A5015129231 @default.
• W2762584480 creator A5015740336 @default.
• W2762584480 creator A5030062838 @default.
• W2762584480 creator A5040327605 @default.
• W2762584480 creator A5049641668 @default.
• W2762584480 creator A5057048732 @default.
• W2762584480 creator A5058249371 @default.
• W2762584480 creator A5061630338 @default.
• W2762584480 creator A5062184356 @default.
• W2762584480 creator A5066447096 @default.
• W2762584480 creator A5070829678 @default.
• W2762584480 creator A5085623211 @default.
• W2762584480 date "2018-01-01" @default.
• W2762584480 modified "2023-10-18" @default.
• W2762584480 title "Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease" @default.
• W2762584480 cites W1902231903 @default.
• W2762584480 cites W1979040675 @default.
• W2762584480 cites W1985830780 @default.
• W2762584480 cites W1987815970 @default.
• W2762584480 cites W1990252413 @default.
• W2762584480 cites W1994380807 @default.
• W2762584480 cites W1998535769 @default.
• W2762584480 cites W2003423561 @default.
• W2762584480 cites W2007747146 @default.
• W2762584480 cites W2010844072 @default.
• W2762584480 cites W2016469998 @default.
• W2762584480 cites W2022634662 @default.
• W2762584480 cites W2022941489 @default.
• W2762584480 cites W2027500788 @default.
• W2762584480 cites W2032295315 @default.
• W2762584480 cites W2039167760 @default.
• W2762584480 cites W2056246727 @default.
• W2762584480 cites W2064372387 @default.
• W2762584480 cites W2066318082 @default.
• W2762584480 cites W2066824747 @default.
• W2762584480 cites W2083196025 @default.
• W2762584480 cites W2085746985 @default.
• W2762584480 cites W2089215286 @default.
• W2762584480 cites W2097141690 @default.
• W2762584480 cites W2101591039 @default.
• W2762584480 cites W2102931921 @default.
• W2762584480 cites W2104551671 @default.
• W2762584480 cites W2108047993 @default.
• W2762584480 cites W2120112732 @default.
• W2762584480 cites W2128406376 @default.
• W2762584480 cites W2129132399 @default.
• W2762584480 cites W2135363031 @default.
• W2762584480 cites W2139214487 @default.
• W2762584480 cites W2141091417 @default.
• W2762584480 cites W2145611575 @default.
• W2762584480 cites W2150908316 @default.
• W2762584480 cites W2154215411 @default.
• W2762584480 cites W2162012182 @default.
• W2762584480 cites W2166796744 @default.
• W2762584480 cites W2208098683 @default.
• W2762584480 cites W2223779815 @default.
• W2762584480 cites W2312795520 @default.
• W2762584480 cites W2317516580 @default.
• W2762584480 cites W2320721555 @default.
• W2762584480 cites W2342250425 @default.
• W2762584480 cites W2345471569 @default.
• W2762584480 cites W2406591348 @default.
• W2762584480 cites W2417434654 @default.
• W2762584480 cites W2521677289 @default.
• W2762584480 cites W2535798987 @default.
• W2762584480 cites W4233502188 @default.
• W2762584480 cites W4252523298 @default.
• W2762584480 cites W4254511229 @default.
• W2762584480 doi "https://doi.org/10.1152/ajplung.00546.2016" @default.
• W2762584480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5866433" @default.
• W2762584480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28982737" @default.
• W2762584480 hasPublicationYear "2018" @default.
• W2762584480 type Work @default.
• W2762584480 sameAs 2762584480 @default.
• W2762584480 citedByCount "24" @default.
• W2762584480 countsByYear W27625844802018 @default.
• W2762584480 countsByYear W27625844802019 @default.
• W2762584480 countsByYear W27625844802020 @default.
• W2762584480 countsByYear W27625844802021 @default.
• W2762584480 countsByYear W27625844802022 @default.
• W2762584480 countsByYear W27625844802023 @default.
• W2762584480 crossrefType "journal-article" @default.
• W2762584480 hasAuthorship W2762584480A5001272649 @default.
• W2762584480 hasAuthorship W2762584480A5002268777 @default.
• W2762584480 hasAuthorship W2762584480A5010493469 @default.
• W2762584480 hasAuthorship W2762584480A5012677805 @default.
• W2762584480 hasAuthorship W2762584480A5015129231 @default.
• W2762584480 hasAuthorship W2762584480A5015740336 @default.
• W2762584480 hasAuthorship W2762584480A5030062838 @default.
• W2762584480 hasAuthorship W2762584480A5040327605 @default.
• W2762584480 hasAuthorship W2762584480A5049641668 @default.
• W2762584480 hasAuthorship W2762584480A5057048732 @default.

• next