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• W2762629397 abstract "In the inflamed gut, the bactericidal lectin RegIIIβ is massively produced by intestinal mucosa. RegIIIβ binds peptidoglycan and lipid A respectively, and thus can kill certain Gram-positive and Gram-negative bacteria, including the gut commensal microbiota and enteropathogenic bacteria. Considering the expression pattern and bactericidal activity, RegIIIβ is believed to be a host defense factor for protecting against the infection with enteropathogenic bacteria. However, it was poorly understood how RegIIIβ recognizes the target bacteria and kill them, and how RegIIIβ plays role(s) in infectious diarrhea. Therefore, our recent study has focused on RegIIIβ-target recognition, killing of Gram-negative bacteria, and host protective functions of RegIIIβ for infectious diarrhea inflicted by Salmonella Typhimurium. Here, we discuss novel insights into the protective role of RegIIIβ in infectious diarrhea, and propose avenues towards novel therapeutic interventions for Salmonella diarrhea." @default.
• W2762629397 created "2017-10-20" @default.
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• W2762629397 date "2017-10-17" @default.
• W2762629397 modified "2023-09-26" @default.
• W2762629397 title "Inflammatory bactericidal lectin RegIIIβ: Friend or foe for the host?" @default.
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• W2762629397 doi "https://doi.org/10.1080/19490976.2017.1387344" @default.
• W2762629397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5989794" @default.
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