FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762770632> ?p ?o ?g. }

• W2762770632 endingPage "1364" @default.
• W2762770632 startingPage "1351" @default.
• W2762770632 abstract "Background:Alzheimer’s disease (AD) is the leading cause of degenerative dementia in the aging population. Patients with AD have alterations in cerebral hemodynamic function including reduced cerebral blood flow (CBF) and cerebral metabolic rate. Therefore, improved cerebrovascular function may be an attractive goal for pharmaceutical intervention in AD. Objective:We wished to observe the acute effects of sildenafil on cerebrovascular function and brain metabolism in patients with AD. Methods:We used several novel non-invasive MRI techniques to investigate the alterations of CBF, cerebral metabolic rate of oxygen (CMRO2), and cerebrovascular reactivity (CVR) after a single dose of sildenafil administration in order to assess its physiological effects in patients with AD. CBF, CMRO2, and CVR measurements using MRI were performed before and one hour after the oral administration of 50 mg sildenafil. Baseline Montreal Cognitive Assessment score was also obtained. Results:Complete CBF and CMRO2 data were obtained in twelve patients. Complete CVR data were obtained in eight patients. Global CBF and CMRO2 significantly increased (p = 0.03, p = 0.05, respectively) following sildenafil administration. Voxel-wise analyses of CBF maps showed that increased CBF was most pronounced in the bilateral medial temporal lobes. CVR significantly decreased after administration of sildenafil. Conclusion:Our data suggest that a single dose of sildenafil improves cerebral hemodynamic function and increases cerebral oxygen metabolism in patients with AD." @default.
• W2762770632 created "2017-10-20" @default.
• W2762770632 creator A5023293183 @default.
• W2762770632 creator A5028883319 @default.
• W2762770632 creator A5029337392 @default.
• W2762770632 creator A5029617270 @default.
• W2762770632 creator A5047269661 @default.
• W2762770632 creator A5057636308 @default.
• W2762770632 creator A5064842058 @default.
• W2762770632 creator A5070439658 @default.
• W2762770632 creator A5073491473 @default.
• W2762770632 date "2017-11-07" @default.
• W2762770632 modified "2023-10-05" @default.
• W2762770632 title "Sildenafil Improves Vascular and Metabolic Function in Patients with Alzheimer’s Disease" @default.
• W2762770632 cites W1595531455 @default.
• W2762770632 cites W1601310757 @default.
• W2762770632 cites W1767010801 @default.
• W2762770632 cites W1917751079 @default.
• W2762770632 cites W1964053234 @default.
• W2762770632 cites W1972418627 @default.
• W2762770632 cites W1973566510 @default.
• W2762770632 cites W1976099054 @default.
• W2762770632 cites W1978654241 @default.
• W2762770632 cites W1981353613 @default.
• W2762770632 cites W1988210470 @default.
• W2762770632 cites W1988532374 @default.
• W2762770632 cites W1994839798 @default.
• W2762770632 cites W1995792973 @default.
• W2762770632 cites W1999890389 @default.
• W2762770632 cites W2002956393 @default.
• W2762770632 cites W2003762128 @default.
• W2762770632 cites W2004388421 @default.
• W2762770632 cites W2005631120 @default.
• W2762770632 cites W2006035554 @default.
• W2762770632 cites W2009482368 @default.
• W2762770632 cites W2011751033 @default.
• W2762770632 cites W2012602334 @default.
• W2762770632 cites W2016069566 @default.
• W2762770632 cites W2016676864 @default.
• W2762770632 cites W2020311830 @default.
• W2762770632 cites W2021657016 @default.
• W2762770632 cites W2023102502 @default.
• W2762770632 cites W2027085222 @default.
• W2762770632 cites W2032210346 @default.
• W2762770632 cites W2032477901 @default.
• W2762770632 cites W2037352700 @default.
• W2762770632 cites W2038194113 @default.
• W2762770632 cites W2041183431 @default.
• W2762770632 cites W2041402562 @default.
• W2762770632 cites W2042335373 @default.
• W2762770632 cites W2042399338 @default.
• W2762770632 cites W2044107858 @default.
• W2762770632 cites W2044132027 @default.
• W2762770632 cites W2045682157 @default.
• W2762770632 cites W2046469028 @default.
• W2762770632 cites W2049268124 @default.
• W2762770632 cites W2051993731 @default.
• W2762770632 cites W2052379663 @default.
• W2762770632 cites W2052588755 @default.
• W2762770632 cites W2054588589 @default.
• W2762770632 cites W2055620557 @default.
• W2762770632 cites W2058046532 @default.
• W2762770632 cites W2069539816 @default.
• W2762770632 cites W2075944057 @default.
• W2762770632 cites W2077466520 @default.
• W2762770632 cites W2077856970 @default.
• W2762770632 cites W2081458774 @default.
• W2762770632 cites W2082000963 @default.
• W2762770632 cites W2082848858 @default.
• W2762770632 cites W2083964290 @default.
• W2762770632 cites W2091134987 @default.
• W2762770632 cites W2102133195 @default.
• W2762770632 cites W2105711200 @default.
• W2762770632 cites W2109139447 @default.
• W2762770632 cites W2113764425 @default.
• W2762770632 cites W2114276034 @default.
• W2762770632 cites W2116530611 @default.
• W2762770632 cites W2116641010 @default.
• W2762770632 cites W2121376498 @default.
• W2762770632 cites W2122901111 @default.
• W2762770632 cites W2124627119 @default.
• W2762770632 cites W2127805507 @default.
• W2762770632 cites W2138675382 @default.
• W2762770632 cites W2140786417 @default.
• W2762770632 cites W2146896966 @default.
• W2762770632 cites W2153669770 @default.
• W2762770632 cites W2155314275 @default.
• W2762770632 cites W2159483285 @default.
• W2762770632 cites W2169566060 @default.
• W2762770632 cites W2169653809 @default.
• W2762770632 cites W2237267942 @default.
• W2762770632 cites W22857079 @default.
• W2762770632 cites W2509545269 @default.
• W2762770632 cites W2553831596 @default.
• W2762770632 cites W2567096679 @default.
• W2762770632 cites W2574596077 @default.
• W2762770632 doi "https://doi.org/10.3233/jad-161006" @default.
• W2762770632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5805465" @default.

• next