Matches in SemOpenAlex for { <https://semopenalex.org/work/W2762788807> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2762788807 abstract "Objective: To determine the pharmacokinetics (PK) and detect changes in cardiac uptake of [123I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in healthy volunteers after exercise-based cardiac stress, to establish a rational basis for studies of focal myocardial hypoxia in cardiac patients using [123I]IAZA. Method: Three healthy male volunteers ran the ‘Bruce’ treadmill protocol (criterion heart rate is 85 % of [220 – age]). Approximately one minute before reaching this level, [123I]IAZA (4.0 mCi/0.85 mg) was administered as a slow (1-3 min) single bolus i.v. injection, then the volunteer continued running for an additional 1 min. Serum from venous blood samples, taken at pre-determined intervals from 1 min to 45 h, was analyzed by radioHPLC. PK parameters were derived for [123I]IAZA and total radioactivity (total[123I]) using compartmental and noncompartmental analyses (NCA). Whole-body planar scintigraphic images were acquired from 0.75 to 24 h after dosing. PK data and scintigraphic images were compared to published data from healthy volunteers administered [123I]IAZA at rest. Results: Following strenuous exercise, both [123I]IAZA and total[123I] exhibited bi-exponential decline profiles, with rapid distribution phases [half-lives (t1/2α) of 1.2 and 1.4 min, respectively], followed by slower elimination phases [t1/2β of 195 and 290 min, respectively]. Total body clearance (CLTB) and steady state volume of distribution (Vss) were 0.647 L/kg and 185 mL/min, respectively, for [123I]IAZA and 0.785 L/kg and 135 mL/min, respectively, for total[123I]. The t1/2β, CLTB and Vss values were comparable to those reported previously for rested volunteers. The t1/2α was approximately 4-fold shorter for [123I]IAZA and approximately 3-fold shorter for total[123I] under exercise relative to rested subjects. The heart was visualized in early whole body scintigraphic images, but overall there were no apparent differences from images reported for rested volunteers. Minimal uptake of radiotracer in myocardium and skeletal muscle was consistent with uptake in non-stressed muscle. Conclusion: The PK and whole-body scintigrams for [123I]IAZA in exercise-stressed healthy volunteers showed no clinically relevant differences relative to non-exercised volunteers. [123I]IAZA may therefore be suitable for the detection of viable, hypoxic myocardium in areas of myocardial perfusion deficiency." @default.
- W2762788807 created "2017-10-20" @default.
- W2762788807 creator A5035258562 @default.
- W2762788807 creator A5044479525 @default.
- W2762788807 creator A5068886356 @default.
- W2762788807 creator A5077958367 @default.
- W2762788807 date "2017-10-06" @default.
- W2762788807 modified "2023-09-26" @default.
- W2762788807 title "Pharmacokinetics of the Hypoxia-Imaging Agent [<sup>123</sup>I]IAZA in Healthy Adults Following Exercise-Based Cardiac Stress" @default.
- W2762788807 cites W1975488630 @default.
- W2762788807 cites W1983099260 @default.
- W2762788807 cites W2064248272 @default.
- W2762788807 cites W2072036968 @default.
- W2762788807 cites W2076093747 @default.
- W2762788807 cites W2100133974 @default.
- W2762788807 cites W2101521188 @default.
- W2762788807 cites W2136431910 @default.
- W2762788807 cites W2281800705 @default.
- W2762788807 cites W2463304284 @default.
- W2762788807 cites W2609808249 @default.
- W2762788807 doi "https://doi.org/10.20944/preprints201710.0034.v1" @default.
- W2762788807 hasPublicationYear "2017" @default.
- W2762788807 type Work @default.
- W2762788807 sameAs 2762788807 @default.
- W2762788807 citedByCount "0" @default.
- W2762788807 crossrefType "posted-content" @default.
- W2762788807 hasAuthorship W2762788807A5035258562 @default.
- W2762788807 hasAuthorship W2762788807A5044479525 @default.
- W2762788807 hasAuthorship W2762788807A5068886356 @default.
- W2762788807 hasAuthorship W2762788807A5077958367 @default.
- W2762788807 hasBestOaLocation W27627888071 @default.
- W2762788807 hasConcept C112705442 @default.
- W2762788807 hasConcept C126322002 @default.
- W2762788807 hasConcept C164705383 @default.
- W2762788807 hasConcept C178790620 @default.
- W2762788807 hasConcept C185592680 @default.
- W2762788807 hasConcept C540031477 @default.
- W2762788807 hasConcept C71924100 @default.
- W2762788807 hasConcept C7836513 @default.
- W2762788807 hasConceptScore W2762788807C112705442 @default.
- W2762788807 hasConceptScore W2762788807C126322002 @default.
- W2762788807 hasConceptScore W2762788807C164705383 @default.
- W2762788807 hasConceptScore W2762788807C178790620 @default.
- W2762788807 hasConceptScore W2762788807C185592680 @default.
- W2762788807 hasConceptScore W2762788807C540031477 @default.
- W2762788807 hasConceptScore W2762788807C71924100 @default.
- W2762788807 hasConceptScore W2762788807C7836513 @default.
- W2762788807 hasLocation W27627888071 @default.
- W2762788807 hasOpenAccess W2762788807 @default.
- W2762788807 hasPrimaryLocation W27627888071 @default.
- W2762788807 hasRelatedWork W191525850 @default.
- W2762788807 hasRelatedWork W1925456755 @default.
- W2762788807 hasRelatedWork W2031799533 @default.
- W2762788807 hasRelatedWork W2080304540 @default.
- W2762788807 hasRelatedWork W2101521188 @default.
- W2762788807 hasRelatedWork W2893751113 @default.
- W2762788807 hasRelatedWork W1521852381 @default.
- W2762788807 hasRelatedWork W2101694379 @default.
- W2762788807 isParatext "false" @default.
- W2762788807 isRetracted "false" @default.
- W2762788807 magId "2762788807" @default.
- W2762788807 workType "article" @default.