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• W2762851710 abstract "Molecular neurobiological insight into human nervous tissues is needed to generate next-generation therapeutics for neurological disorders such as chronic pain. We obtained human dorsal root ganglia (hDRG) samples from organ donors and performed RNA-sequencing (RNA-seq) to study the hDRG transcriptional landscape, systematically comparing it with publicly available data from a variety of human and orthologous mouse tissues, including mouse DRG (mDRG). We characterized the hDRG transcriptional profile in terms of tissue-restricted gene coexpression patterns and putative transcriptional regulators, and formulated an information-theoretic framework to quantify DRG enrichment. Relevant gene families and pathways were also analyzed, including transcription factors, G-protein-coupled receptors, and ion channels. Our analyses reveal an hDRG-enriched protein-coding gene set (∼140), some of which have not been described in the context of DRG or pain signaling. Most of these show conserved enrichment in mDRG and were mined for known drug-gene product interactions. Conserved enrichment of the vast majority of transcription factors suggests that the mDRG is a faithful model system for studying hDRG, because of evolutionarily conserved regulatory programs. Comparison of hDRG and tibial nerve transcriptomes suggests trafficking of neuronal mRNA to axons in adult hDRG, and are consistent with studies of axonal transport in rodent sensory neurons. We present our work as an online, searchable repository (https://www.utdallas.edu/bbs/painneurosciencelab/sensoryomics/drgtxome), creating a valuable resource for the community. Our analyses provide insight into DRG biology for guiding development of novel therapeutics and a blueprint for cross-species transcriptomic analyses." @default.
• W2762851710 created "2017-10-20" @default.
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• W2762851710 date "2018-03-20" @default.
• W2762851710 modified "2023-10-10" @default.
• W2762851710 title "Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research" @default.
• W2762851710 cites W1512337699 @default.
• W2762851710 cites W1513058165 @default.
• W2762851710 cites W1552434751 @default.
• W2762851710 cites W1566952502 @default.
• W2762851710 cites W1600275962 @default.
• W2762851710 cites W1621681231 @default.
• W2762851710 cites W1731795725 @default.
• W2762851710 cites W1813348106 @default.
• W2762851710 cites W1882985910 @default.
• W2762851710 cites W1928871450 @default.
• W2762851710 cites W1964117008 @default.
• W2762851710 cites W1967368719 @default.
• W2762851710 cites W1967450550 @default.
• W2762851710 cites W1974773959 @default.
• W2762851710 cites W1976437851 @default.
• W2762851710 cites W1978286026 @default.
• W2762851710 cites W1986172894 @default.
• W2762851710 cites W1988635251 @default.
• W2762851710 cites W1989277387 @default.
• W2762851710 cites W1990872505 @default.
• W2762851710 cites W1993218073 @default.
• W2762851710 cites W1995758351 @default.
• W2762851710 cites W1999194329 @default.
• W2762851710 cites W1999195261 @default.
• W2762851710 cites W2004040924 @default.
• W2762851710 cites W2006210604 @default.
• W2762851710 cites W2007272144 @default.
• W2762851710 cites W2007467986 @default.
• W2762851710 cites W2008958407 @default.
• W2762851710 cites W2011139091 @default.
• W2762851710 cites W2012815395 @default.
• W2762851710 cites W2013469333 @default.
• W2762851710 cites W2015363965 @default.
• W2762851710 cites W2018838463 @default.
• W2762851710 cites W2022825068 @default.
• W2762851710 cites W2027823805 @default.
• W2762851710 cites W2027889563 @default.
• W2762851710 cites W2030895625 @default.
• W2762851710 cites W2031892070 @default.
• W2762851710 cites W2032585435 @default.
• W2762851710 cites W2033072655 @default.
• W2762851710 cites W2033727415 @default.
• W2762851710 cites W2036887984 @default.
• W2762851710 cites W2037615805 @default.
• W2762851710 cites W2037780745 @default.
• W2762851710 cites W2038338205 @default.
• W2762851710 cites W2041641828 @default.
• W2762851710 cites W2045117214 @default.
• W2762851710 cites W2048368626 @default.
• W2762851710 cites W2051118171 @default.
• W2762851710 cites W2057507618 @default.
• W2762851710 cites W2058409422 @default.
• W2762851710 cites W2060330296 @default.
• W2762851710 cites W2063223078 @default.
• W2762851710 cites W2064564039 @default.
• W2762851710 cites W2070050178 @default.
• W2762851710 cites W2073035767 @default.
• W2762851710 cites W2074871118 @default.
• W2762851710 cites W2082682623 @default.
• W2762851710 cites W2083017377 @default.
• W2762851710 cites W2084447782 @default.
• W2762851710 cites W2087768763 @default.
• W2762851710 cites W2087782077 @default.
• W2762851710 cites W2089172126 @default.
• W2762851710 cites W2089617519 @default.
• W2762851710 cites W2090905251 @default.
• W2762851710 cites W2096465161 @default.
• W2762851710 cites W2097065948 @default.
• W2762851710 cites W2098400976 @default.
• W2762851710 cites W2098638804 @default.
• W2762851710 cites W2100305481 @default.
• W2762851710 cites W2103017472 @default.
• W2762851710 cites W2105924489 @default.
• W2762851710 cites W2107936815 @default.
• W2762851710 cites W2109655788 @default.
• W2762851710 cites W2109871821 @default.
• W2762851710 cites W2110256992 @default.
• W2762851710 cites W2110387447 @default.
• W2762851710 cites W2118191045 @default.
• W2762851710 cites W2120865735 @default.
• W2762851710 cites W2121211805 @default.

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