FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763043436> ?p ?o ?g. }

• W2763043436 abstract "Crosstalk between the androgen receptor (AR) and other signaling pathways in prostate cancer (PCa) severely affects the therapeutic outcome of hormonal therapy. Although anti-androgen therapy prolongs overall survival in PCa patients, resistance rapidly develops and is often associated with increased AR expression and upregulation of the HER2/3-AKT signaling pathway. However, single agent therapy targeting AR, HER2/3 or AKT usually fails due to the reciprocal feedback loop. Previously, we reported that wedelolactone, apigenin, and luteolin are the active compounds in Wedelia chinensis herbal extract, and act synergistically to inhibit the AR activity in PCa. Here, we further demonstrated that an herbal extract of W. chinensis (WCE) effectively disrupted the AR, HER2/3, and AKT signaling networks and therefore enhanced the therapeutic efficacy of androgen ablation in PCa. Furthermore, WCE remained effective in suppressing AR and HER2/3 signaling in an in vivo adapted castration-resistant PCa (CRPC) LNCaP cell model that was insensitive to androgen withdrawal and second-line antiandrogen, enzalutamide. This study provides preclinical evidence that the use of a defined, single plant-derived extract can augment the therapeutic efficacy of castration with significantly prolonged progression-free survival. These data also establish a solid basis for using WCE as a candidate agent in clinical studies." @default.
• W2763043436 created "2017-10-20" @default.
• W2763043436 creator A5008173365 @default.
• W2763043436 creator A5024922159 @default.
• W2763043436 creator A5040305503 @default.
• W2763043436 creator A5045950973 @default.
• W2763043436 creator A5050389696 @default.
• W2763043436 creator A5065062397 @default.
• W2763043436 creator A5076781720 @default.
• W2763043436 date "2017-10-10" @default.
• W2763043436 modified "2023-10-18" @default.
• W2763043436 title "A Standardized Wedelia chinensis Extract Overcomes the Feedback Activation of HER2/3 Signaling upon Androgen-Ablation in Prostate Cancer" @default.
• W2763043436 cites W1204692252 @default.
• W2763043436 cites W1528881540 @default.
• W2763043436 cites W1578291413 @default.
• W2763043436 cites W1848444843 @default.
• W2763043436 cites W1949736479 @default.
• W2763043436 cites W1972969589 @default.
• W2763043436 cites W1974006411 @default.
• W2763043436 cites W1976980728 @default.
• W2763043436 cites W1977529632 @default.
• W2763043436 cites W1981190584 @default.
• W2763043436 cites W1982316496 @default.
• W2763043436 cites W1985360090 @default.
• W2763043436 cites W1985536810 @default.
• W2763043436 cites W1987118666 @default.
• W2763043436 cites W1990761421 @default.
• W2763043436 cites W1992394857 @default.
• W2763043436 cites W1998691242 @default.
• W2763043436 cites W2000158828 @default.
• W2763043436 cites W2004958423 @default.
• W2763043436 cites W2005302422 @default.
• W2763043436 cites W2007558014 @default.
• W2763043436 cites W2007699862 @default.
• W2763043436 cites W2013611824 @default.
• W2763043436 cites W2022635468 @default.
• W2763043436 cites W2022653867 @default.
• W2763043436 cites W2024534768 @default.
• W2763043436 cites W2029054015 @default.
• W2763043436 cites W2037122592 @default.
• W2763043436 cites W2037690883 @default.
• W2763043436 cites W2037852023 @default.
• W2763043436 cites W2039923077 @default.
• W2763043436 cites W2051202261 @default.
• W2763043436 cites W2053116646 @default.
• W2763043436 cites W2053223343 @default.
• W2763043436 cites W2064927794 @default.
• W2763043436 cites W2073100248 @default.
• W2763043436 cites W2077863736 @default.
• W2763043436 cites W2104345898 @default.
• W2763043436 cites W2105829250 @default.
• W2763043436 cites W2106339174 @default.
• W2763043436 cites W2107633226 @default.
• W2763043436 cites W2112568160 @default.
• W2763043436 cites W2115379976 @default.
• W2763043436 cites W2125066279 @default.
• W2763043436 cites W2127373124 @default.
• W2763043436 cites W2130986416 @default.
• W2763043436 cites W2132405742 @default.
• W2763043436 cites W2135231147 @default.
• W2763043436 cites W2136700586 @default.
• W2763043436 cites W2143245184 @default.
• W2763043436 cites W2143618467 @default.
• W2763043436 cites W2148126031 @default.
• W2763043436 cites W2155081607 @default.
• W2763043436 cites W2155973842 @default.
• W2763043436 cites W2163895012 @default.
• W2763043436 cites W2165539951 @default.
• W2763043436 cites W2166435610 @default.
• W2763043436 cites W2167609397 @default.
• W2763043436 cites W2169646124 @default.
• W2763043436 cites W2170071316 @default.
• W2763043436 cites W2289154056 @default.
• W2763043436 cites W2528305152 @default.
• W2763043436 doi "https://doi.org/10.3389/fphar.2017.00721" @default.
• W2763043436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5641394" @default.
• W2763043436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29066975" @default.
• W2763043436 hasPublicationYear "2017" @default.
• W2763043436 type Work @default.
• W2763043436 sameAs 2763043436 @default.
• W2763043436 citedByCount "9" @default.
• W2763043436 countsByYear W27630434362018 @default.
• W2763043436 countsByYear W27630434362019 @default.
• W2763043436 countsByYear W27630434362020 @default.
• W2763043436 countsByYear W27630434362021 @default.
• W2763043436 countsByYear W27630434362022 @default.
• W2763043436 crossrefType "journal-article" @default.
• W2763043436 hasAuthorship W2763043436A5008173365 @default.
• W2763043436 hasAuthorship W2763043436A5024922159 @default.
• W2763043436 hasAuthorship W2763043436A5040305503 @default.
• W2763043436 hasAuthorship W2763043436A5045950973 @default.
• W2763043436 hasAuthorship W2763043436A5050389696 @default.
• W2763043436 hasAuthorship W2763043436A5065062397 @default.
• W2763043436 hasAuthorship W2763043436A5076781720 @default.
• W2763043436 hasBestOaLocation W27630434361 @default.
• W2763043436 hasConcept C104317684 @default.
• W2763043436 hasConcept C121608353 @default.
• W2763043436 hasConcept C126322002 @default.
• W2763043436 hasConcept C127561419 @default.
• W2763043436 hasConcept C185592680 @default.

• next