FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763048132> ?p ?o ?g. }

• W2763048132 abstract "Knowledge of the spatial organization of the gut microbiota is important for understanding the physical and molecular interactions among its members. These interactions are thought to influence microbial succession, community stability, syntrophic relationships, and resiliency in the face of perturbations. The complexity and dynamism of the gut microbiota pose considerable challenges for quantitative analysis of its spatial organization. Here, we illustrate an approach for addressing this challenge, using (i) a model, defined 15-member consortium of phylogenetically diverse, sequenced human gut bacterial strains introduced into adult gnotobiotic mice fed a polysaccharide-rich diet, and (ii) in situ hybridization and spectral imaging analysis methods that allow simultaneous detection of multiple bacterial strains at multiple spatial scales. Differences in the binding affinities of strains for substrates such as mucus or food particles, combined with more rapid replication in a preferred microhabitat, could, in principle, lead to localized clonally expanded aggregates composed of one or a few taxa. However, our results reveal a colonic community that is mixed at micrometer scales, with distinct spatial distributions of some taxa relative to one another, notably at the border between the mucosa and the lumen. Our data suggest that lumen and mucosa in the proximal colon should be conceptualized not as stratified compartments but as components of an incompletely mixed bioreactor. Employing the experimental approaches described should allow direct tests of whether and how specified host and microbial factors influence the nature and functional contributions of microscale mixing to the dynamic operations of the microbiota in health and disease." @default.
• W2763048132 created "2017-10-20" @default.
• W2763048132 creator A5002316771 @default.
• W2763048132 creator A5015283730 @default.
• W2763048132 creator A5040640437 @default.
• W2763048132 creator A5044247683 @default.
• W2763048132 creator A5063884903 @default.
• W2763048132 date "2017-10-09" @default.
• W2763048132 modified "2023-10-16" @default.
• W2763048132 title "Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice" @default.
• W2763048132 cites W1489080036 @default.
• W2763048132 cites W1701869895 @default.
• W2763048132 cites W1852244784 @default.
• W2763048132 cites W1902150932 @default.
• W2763048132 cites W1945011216 @default.
• W2763048132 cites W1961184135 @default.
• W2763048132 cites W1965460969 @default.
• W2763048132 cites W1968026360 @default.
• W2763048132 cites W1977852030 @default.
• W2763048132 cites W1978195655 @default.
• W2763048132 cites W1983198643 @default.
• W2763048132 cites W1992007782 @default.
• W2763048132 cites W2012606594 @default.
• W2763048132 cites W2012994611 @default.
• W2763048132 cites W2014209146 @default.
• W2763048132 cites W2017402185 @default.
• W2763048132 cites W2019374755 @default.
• W2763048132 cites W2020978031 @default.
• W2763048132 cites W2021053249 @default.
• W2763048132 cites W2023649138 @default.
• W2763048132 cites W2026458018 @default.
• W2763048132 cites W2030364983 @default.
• W2763048132 cites W2033170006 @default.
• W2763048132 cites W2037001083 @default.
• W2763048132 cites W2037176611 @default.
• W2763048132 cites W2044977356 @default.
• W2763048132 cites W2046753869 @default.
• W2763048132 cites W2050609241 @default.
• W2763048132 cites W2053830048 @default.
• W2763048132 cites W2065540788 @default.
• W2763048132 cites W2068734008 @default.
• W2763048132 cites W2088533694 @default.
• W2763048132 cites W2090304005 @default.
• W2763048132 cites W2092083061 @default.
• W2763048132 cites W2092450605 @default.
• W2763048132 cites W2094934457 @default.
• W2763048132 cites W2097177097 @default.
• W2763048132 cites W2098129968 @default.
• W2763048132 cites W2099540110 @default.
• W2763048132 cites W2102868720 @default.
• W2763048132 cites W2104593962 @default.
• W2763048132 cites W2105259969 @default.
• W2763048132 cites W2120350772 @default.
• W2763048132 cites W2120767803 @default.
• W2763048132 cites W2121929631 @default.
• W2763048132 cites W2122414480 @default.
• W2763048132 cites W2124128320 @default.
• W2763048132 cites W2126452774 @default.
• W2763048132 cites W2127681878 @default.
• W2763048132 cites W2129193083 @default.
• W2763048132 cites W2129675095 @default.
• W2763048132 cites W2143777796 @default.
• W2763048132 cites W2145945191 @default.
• W2763048132 cites W2147296837 @default.
• W2763048132 cites W2153732314 @default.
• W2763048132 cites W2155806125 @default.
• W2763048132 cites W2155923760 @default.
• W2763048132 cites W2162133321 @default.
• W2763048132 cites W2164683004 @default.
• W2763048132 cites W2167279371 @default.
• W2763048132 cites W2168860582 @default.
• W2763048132 cites W2171963518 @default.
• W2763048132 cites W2214747519 @default.
• W2763048132 cites W2219990459 @default.
• W2763048132 cites W2252298505 @default.
• W2763048132 cites W2253934566 @default.
• W2763048132 cites W2308597139 @default.
• W2763048132 cites W2323974245 @default.
• W2763048132 cites W2328023807 @default.
• W2763048132 cites W2462369005 @default.
• W2763048132 cites W2465777910 @default.
• W2763048132 cites W2526011394 @default.
• W2763048132 cites W2580619720 @default.
• W2763048132 cites W2605479728 @default.
• W2763048132 cites W2605788558 @default.
• W2763048132 cites W2607489768 @default.
• W2763048132 cites W2949165124 @default.
• W2763048132 cites W2950104603 @default.
• W2763048132 cites W4243390175 @default.
• W2763048132 cites W4247382314 @default.
• W2763048132 doi "https://doi.org/10.1073/pnas.1711596114" @default.
• W2763048132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5664539" @default.
• W2763048132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29073107" @default.
• W2763048132 hasPublicationYear "2017" @default.
• W2763048132 type Work @default.
• W2763048132 sameAs 2763048132 @default.
• W2763048132 citedByCount "177" @default.
• W2763048132 countsByYear W27630481322017 @default.
• W2763048132 countsByYear W27630481322018 @default.
• W2763048132 countsByYear W27630481322019 @default.

• next