FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763048265> ?p ?o ?g. }

• W2763048265 endingPage "842" @default.
• W2763048265 startingPage "827" @default.
• W2763048265 abstract "Lipid metabolism disorders (dyslipidemia) are causes of male infertility, but little is known about their impact on male gametes when considering post-testicular maturation events, given that studies concentrate most often on endocrine dysfunctions and testicular consequences. In this study, three-month-old wild-type (wt) and Liver-X-Receptors knock out (Lxrα;β-/- ) males were fed four weeks with a control or a lipid-enriched diet containing 1.25% cholesterol (high cholesterol diet (HCD)). The HCD triggered a dyslipidemia leading to sperm post-testicular alterations and infertility. Sperm lipids were analyzed by LC-MS and those from Lxrα;β-/- males fed the HCD showed higher chol/PL and PC/PE ratios compared to wt-HCD (P < 0.05) and lower oxysterol contents compared to wt (P < 0.05) or Lxrα;β-/- (P < 0.05). These modifications impaired membrane-associated events triggering the tyrosine phosphorylation normally occurring during the capacitation process, as shown by phosphotyrosine Western blots. Using flow cytometry, we showed that a smaller subpopulation of spermatozoa from Lxrα;β-/- -HCD males could raise their membrane fluidity during capacitation (P < 0.05 vs wt or wt-HCD) as well as their intracellular calcium concentration (P < 0.05 vs Lxrα;β-/- and P < 0.001 vs wt). The accumulation of the major sperm calcium efflux pump (PMCA4) was decreased in Lxrα;β-/- males fed the HCD (P < 0.05 vs Lxrα;β-/- and P < 0.001 vs wt). This study is the first showing an impact of dyslipidemia on post-testicular sperm maturation with consequences on the capacitation signaling cascade. It may lead to the identification of fertility prognostic markers in this pathophysiological situation, which could help clinicians to better understand male infertilities which are thus far classified as idiopathic." @default.
• W2763048265 created "2017-10-20" @default.
• W2763048265 creator A5006685225 @default.
• W2763048265 creator A5009918250 @default.
• W2763048265 creator A5027864929 @default.
• W2763048265 creator A5059041385 @default.
• W2763048265 creator A5067788619 @default.
• W2763048265 creator A5072207628 @default.
• W2763048265 creator A5078415746 @default.
• W2763048265 date "2017-12-01" @default.
• W2763048265 modified "2023-10-01" @default.
• W2763048265 title "Dyslipidemia alters sperm maturation and capacitation in LXR-null mice" @default.
• W2763048265 cites W1504025533 @default.
• W2763048265 cites W1531722346 @default.
• W2763048265 cites W1603617892 @default.
• W2763048265 cites W1870184698 @default.
• W2763048265 cites W1968069591 @default.
• W2763048265 cites W1987032312 @default.
• W2763048265 cites W1987162379 @default.
• W2763048265 cites W1990632046 @default.
• W2763048265 cites W1993625619 @default.
• W2763048265 cites W1995936745 @default.
• W2763048265 cites W1996233224 @default.
• W2763048265 cites W1996602661 @default.
• W2763048265 cites W1996887214 @default.
• W2763048265 cites W1997295104 @default.
• W2763048265 cites W2010397653 @default.
• W2763048265 cites W2010945726 @default.
• W2763048265 cites W2012501909 @default.
• W2763048265 cites W2014192887 @default.
• W2763048265 cites W2014326045 @default.
• W2763048265 cites W2016414410 @default.
• W2763048265 cites W2019562799 @default.
• W2763048265 cites W2023889459 @default.
• W2763048265 cites W2028773449 @default.
• W2763048265 cites W2031769175 @default.
• W2763048265 cites W2037146629 @default.
• W2763048265 cites W2037397796 @default.
• W2763048265 cites W2040080912 @default.
• W2763048265 cites W2044201289 @default.
• W2763048265 cites W2044311796 @default.
• W2763048265 cites W2070395955 @default.
• W2763048265 cites W2077079040 @default.
• W2763048265 cites W2082586399 @default.
• W2763048265 cites W2088115212 @default.
• W2763048265 cites W2107293911 @default.
• W2763048265 cites W2108134879 @default.
• W2763048265 cites W2109279728 @default.
• W2763048265 cites W2110585531 @default.
• W2763048265 cites W2118149443 @default.
• W2763048265 cites W2121236575 @default.
• W2763048265 cites W2126377977 @default.
• W2763048265 cites W2132871071 @default.
• W2763048265 cites W2139412501 @default.
• W2763048265 cites W2139936833 @default.
• W2763048265 cites W2148257095 @default.
• W2763048265 cites W2152311269 @default.
• W2763048265 cites W2155991068 @default.
• W2763048265 cites W2157419912 @default.
• W2763048265 cites W2158297231 @default.
• W2763048265 cites W2168526937 @default.
• W2763048265 cites W2201382378 @default.
• W2763048265 cites W2210080033 @default.
• W2763048265 cites W2281609143 @default.
• W2763048265 cites W2300361661 @default.
• W2763048265 cites W2337792773 @default.
• W2763048265 cites W2463125629 @default.
• W2763048265 cites W4213156224 @default.
• W2763048265 cites W4240348883 @default.
• W2763048265 cites W4247800480 @default.
• W2763048265 cites W4293084779 @default.
• W2763048265 doi "https://doi.org/10.1530/rep-17-0467" @default.
• W2763048265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28971895" @default.
• W2763048265 hasPublicationYear "2017" @default.
• W2763048265 type Work @default.
• W2763048265 sameAs 2763048265 @default.
• W2763048265 citedByCount "11" @default.
• W2763048265 countsByYear W27630482652018 @default.
• W2763048265 countsByYear W27630482652019 @default.
• W2763048265 countsByYear W27630482652021 @default.
• W2763048265 countsByYear W27630482652022 @default.
• W2763048265 countsByYear W27630482652023 @default.
• W2763048265 crossrefType "journal-article" @default.
• W2763048265 hasAuthorship W2763048265A5006685225 @default.
• W2763048265 hasAuthorship W2763048265A5009918250 @default.
• W2763048265 hasAuthorship W2763048265A5027864929 @default.
• W2763048265 hasAuthorship W2763048265A5059041385 @default.
• W2763048265 hasAuthorship W2763048265A5067788619 @default.
• W2763048265 hasAuthorship W2763048265A5072207628 @default.
• W2763048265 hasAuthorship W2763048265A5078415746 @default.
• W2763048265 hasBestOaLocation W27630482651 @default.
• W2763048265 hasConcept C126322002 @default.
• W2763048265 hasConcept C134018914 @default.
• W2763048265 hasConcept C16685009 @default.
• W2763048265 hasConcept C170493617 @default.
• W2763048265 hasConcept C185592680 @default.
• W2763048265 hasConcept C2777553839 @default.
• W2763048265 hasConcept C2778096610 @default.

• next