Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763048353> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2763048353 endingPage "v563" @default.
- W2763048353 startingPage "v563" @default.
- W2763048353 abstract "Background: The survival rate of childhood cancer is approaching to over 80%, and survivorship is gathering more attention. The survivors receive chemotherapy, radiotherapy and surgery in their early life stages, and the risk of ototoxicity is increased. We evaluated the degree of risk of the clinical factors causing the ototoxicy, in childhood cancer survivors. Methods: We established survivorship program for late effects in Yonsei Cancer Center, Seoul, Korea. In all 531 enrolled survivors in the clinic, 105 patients were invited to evaluate otoxocitity in their bi-annual visits and the clinical risk factors were reviewed retrospectively. Results: The median age at diagnosis was 6.0 (0∼26). Most common diagnosis was leukemia/lymphoma (N = 30, 30%), and brain tumor was the next (N = 29, 29%). Platinum agents were used in 64%, alkylating agents was in 83% and vinca alkaloid was in 78%. Severe hearing impairments defined as over than 60 dB loss were observed in 37% of left ears and 39% of right ears. The proportion of the survivors who had 20 dB loss in any side of ears was 28%. The 69% of abdomen tumor survivors and 56% of brain tumors had any of hearing impairments, but only 28% of leukemia/lymphoma survivors showed hearing loss (P < 0.001). The class of platinum agents use, vinca alkoids were adverse factors, however, the class of antimetabolites use or antibiotics use were all protective factors for hearing impairments (P < 0.001, <0.001, 0.006, <0.001, respectively). Both use of platinum and vinca alkaloids showed significantly higher risk of hearing impairments compared with use of none or one class of two classes of agents (P < 0.001 for right ear and P < 0.001 for left ear). Young age at diagnosis (<7.5 years old) showed higher risk of hearing loss in abdomen tumor and brain tumor group (P = 0.006 for right, P = 0.051 for left). Total 5000 cGy or more of head and neck region radiation showed increased risk (P = 0.001 for right, P = 0.007 for left). In multivariate analysis, both use of platinum and vinca alkaloids was independent risk factor (O.R.=8.1, P = 0.004 for right; O.R.= 8.7, P = 0.004 for left). Conclusions: Hearing impairments were common late effects in childhood cancer survivors, and vinca alkaloids had additive adverse effects on the platinum use for the hearing loss. Legal entity responsible for the study: Jung Woo Han Funding: None Disclosure: All authors have declared no conflicts of interest." @default.
- W2763048353 created "2017-10-20" @default.
- W2763048353 creator A5007821465 @default.
- W2763048353 creator A5019527882 @default.
- W2763048353 creator A5052345152 @default.
- W2763048353 creator A5052794612 @default.
- W2763048353 creator A5074049980 @default.
- W2763048353 creator A5087299509 @default.
- W2763048353 date "2017-09-01" @default.
- W2763048353 modified "2023-09-28" @default.
- W2763048353 title "Additive effect of vinca alkaloids as the risk factor for hearing impairments in the childhood cancer survivors" @default.
- W2763048353 doi "https://doi.org/10.1093/annonc/mdx388.059" @default.
- W2763048353 hasPublicationYear "2017" @default.
- W2763048353 type Work @default.
- W2763048353 sameAs 2763048353 @default.
- W2763048353 citedByCount "0" @default.
- W2763048353 crossrefType "journal-article" @default.
- W2763048353 hasAuthorship W2763048353A5007821465 @default.
- W2763048353 hasAuthorship W2763048353A5019527882 @default.
- W2763048353 hasAuthorship W2763048353A5052345152 @default.
- W2763048353 hasAuthorship W2763048353A5052794612 @default.
- W2763048353 hasAuthorship W2763048353A5074049980 @default.
- W2763048353 hasAuthorship W2763048353A5087299509 @default.
- W2763048353 hasBestOaLocation W27630483531 @default.
- W2763048353 hasConcept C121608353 @default.
- W2763048353 hasConcept C126322002 @default.
- W2763048353 hasConcept C143998085 @default.
- W2763048353 hasConcept C172400760 @default.
- W2763048353 hasConcept C197934379 @default.
- W2763048353 hasConcept C2776553716 @default.
- W2763048353 hasConcept C2776694085 @default.
- W2763048353 hasConcept C2776755627 @default.
- W2763048353 hasConcept C2777096885 @default.
- W2763048353 hasConcept C2778239845 @default.
- W2763048353 hasConcept C2778461978 @default.
- W2763048353 hasConcept C2778534666 @default.
- W2763048353 hasConcept C2779429289 @default.
- W2763048353 hasConcept C2780493683 @default.
- W2763048353 hasConcept C509974204 @default.
- W2763048353 hasConcept C548259974 @default.
- W2763048353 hasConcept C71924100 @default.
- W2763048353 hasConcept C98274493 @default.
- W2763048353 hasConceptScore W2763048353C121608353 @default.
- W2763048353 hasConceptScore W2763048353C126322002 @default.
- W2763048353 hasConceptScore W2763048353C143998085 @default.
- W2763048353 hasConceptScore W2763048353C172400760 @default.
- W2763048353 hasConceptScore W2763048353C197934379 @default.
- W2763048353 hasConceptScore W2763048353C2776553716 @default.
- W2763048353 hasConceptScore W2763048353C2776694085 @default.
- W2763048353 hasConceptScore W2763048353C2776755627 @default.
- W2763048353 hasConceptScore W2763048353C2777096885 @default.
- W2763048353 hasConceptScore W2763048353C2778239845 @default.
- W2763048353 hasConceptScore W2763048353C2778461978 @default.
- W2763048353 hasConceptScore W2763048353C2778534666 @default.
- W2763048353 hasConceptScore W2763048353C2779429289 @default.
- W2763048353 hasConceptScore W2763048353C2780493683 @default.
- W2763048353 hasConceptScore W2763048353C509974204 @default.
- W2763048353 hasConceptScore W2763048353C548259974 @default.
- W2763048353 hasConceptScore W2763048353C71924100 @default.
- W2763048353 hasConceptScore W2763048353C98274493 @default.
- W2763048353 hasLocation W27630483531 @default.
- W2763048353 hasOpenAccess W2763048353 @default.
- W2763048353 hasPrimaryLocation W27630483531 @default.
- W2763048353 hasRelatedWork W1970429236 @default.
- W2763048353 hasRelatedWork W2053825022 @default.
- W2763048353 hasRelatedWork W2083736362 @default.
- W2763048353 hasRelatedWork W2112851763 @default.
- W2763048353 hasRelatedWork W2404042595 @default.
- W2763048353 hasRelatedWork W2419317782 @default.
- W2763048353 hasRelatedWork W2466163406 @default.
- W2763048353 hasRelatedWork W3089027962 @default.
- W2763048353 hasRelatedWork W4234620575 @default.
- W2763048353 hasRelatedWork W4294936145 @default.
- W2763048353 hasVolume "28" @default.
- W2763048353 isParatext "false" @default.
- W2763048353 isRetracted "false" @default.
- W2763048353 magId "2763048353" @default.
- W2763048353 workType "article" @default.