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- W2763049306 abstract "One of the major pathogenesis of coronary heart disease is hyperchoresterolemiaAlthough choresterol reducing therapy can decrease the morbidity and mortality ofcoronary heart disease,what is less certain is the portential antimyocardial ischemiaeffect of it.Besides the conventional therapy,the application of choresterol reducingtherapy can decrease the onset of transient myocardial ischemia in patients withunstable angina in this trial,we initiated the application of 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibitor pravastatin to reduce thelevel of serum total choresterol and LDL-C(low-density lipoprotein choresterol) andto decrease the onset of transient myocardial ischemia in pationts with stable angina ofcoronary heart disease.Patient selection.There were 368 patients aged 45-80 years,with stable angina of coronary heart discase and hyperlipidemia,randomized intopravastatin group and placebo group besides the convientional antiangina therapy in12 months,with 266 male and 102 female.Serum total choresterol was 4-8mmol/L(155-310mg/dL).All patients received 48 hours Hoter monitoring pre andpost the trial.The definition of the onset of transient myocardial ischemia isdownsloping or horizontal ST segment depression≥0.1mv from 80msec after the Jpoint with duration≥60secends.I.In pravastatin group,the level of serum totalchoresterol and LDL--C reduced significantly(total choresterol from 6.08 mmol/L to4.80mmol/L,LDL-C from 4.20 mmol/L to 1.46 mmol/L),high-density lipoproteinchoresterol raised markedly(from 0.9 mmol/L to 1.02 mmol/L),p<0.001.Nosignificant change was noted in placebo group.2.Inpravastatin group,the onset oftransient myocardial ischemia was 26% before the trial.and was 19% after the trial.While in placebo group,the rate was 19% to 22% reapectively.There were significantdifference between the two groups.3.Duration of the episode of transient myocardialisohemis was shortened from 80±12 seconds to 42±10 seconds in pravastatin groupand was shortened from 60±13 seconds to 51±9" @default.
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- W2763049306 date "1998-01-01" @default.
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- W2763049306 title "Effcet of Pravastatin to Reduce the Onset of Transient Myocardial lschemia in Patients with Stable Angina of Coronary Heart Disease" @default.
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