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• W2763141254 endingPage "117" @default.
• W2763141254 startingPage "90" @default.
• W2763141254 abstract "Metallothioneins (MTs) belong to a group of small cysteine-rich proteins that are ubiquitous throughout all kingdoms. The main function of MTs is scavenging of free radicals and detoxification and homeostating of heavy metals. In humans, 16 genes localized on chromosome 16 have been identified to encode four MT isoforms labelled by numbers (MT-1–MT-4). MT-2, MT-3 and MT-4 proteins are encoded by a single gene. MT-1 comprises many (sub)isoforms. The known active MT-1 genes are MT-1A, -1B, -1E, -1F, -1G, -1H, -1M and -1X. The rest of the MT-1 genes (MT-1C, -1D, -1I, -1J and -1L) are pseudogenes. The expression and localization of individual MT (sub)isoforms and pseudogenes vary at intra-cellular level and in individual tissues. Changes in MT expression are associated with the process of carcinogenesis of various types of human malignancies, or with a more aggressive phenotype and therapeutic resistance. Hence, MT (sub)isoform profiling status could be utilized for diagnostics and therapy of tumour diseases. This review aims on a comprehensive summary of methods for analysis of MTs at (sub)isoforms levels, their expression in single tumour diseases and strategies how this knowledge can be utilized in anticancer therapy." @default.
• W2763141254 created "2017-10-20" @default.
• W2763141254 creator A5002161879 @default.
• W2763141254 creator A5006376053 @default.
• W2763141254 creator A5009212415 @default.
• W2763141254 creator A5013532796 @default.
• W2763141254 creator A5018934612 @default.
• W2763141254 creator A5023745218 @default.
• W2763141254 creator A5029010301 @default.
• W2763141254 creator A5047361220 @default.
• W2763141254 date "2018-03-01" @default.
• W2763141254 modified "2023-09-30" @default.
• W2763141254 title "An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena" @default.
• W2763141254 cites W1135227129 @default.
• W2763141254 cites W1235656097 @default.
• W2763141254 cites W1493599521 @default.
• W2763141254 cites W1514171077 @default.
• W2763141254 cites W1520066951 @default.
• W2763141254 cites W1579115730 @default.
• W2763141254 cites W1586104958 @default.
• W2763141254 cites W1589330557 @default.
• W2763141254 cites W1625383933 @default.
• W2763141254 cites W1733825710 @default.
• W2763141254 cites W1749717612 @default.
• W2763141254 cites W1768737229 @default.
• W2763141254 cites W1830834118 @default.
• W2763141254 cites W1843842753 @default.
• W2763141254 cites W1888095197 @default.
• W2763141254 cites W1916322263 @default.
• W2763141254 cites W1931084896 @default.
• W2763141254 cites W1932561020 @default.
• W2763141254 cites W1946846784 @default.
• W2763141254 cites W1964734417 @default.
• W2763141254 cites W1965528165 @default.
• W2763141254 cites W1965536430 @default.
• W2763141254 cites W1966269491 @default.
• W2763141254 cites W1967159277 @default.
• W2763141254 cites W1967623316 @default.
• W2763141254 cites W1969125730 @default.
• W2763141254 cites W1971992755 @default.
• W2763141254 cites W1974130458 @default.
• W2763141254 cites W1975206709 @default.
• W2763141254 cites W1975401825 @default.
• W2763141254 cites W1975434454 @default.
• W2763141254 cites W1976094219 @default.
• W2763141254 cites W1976835022 @default.
• W2763141254 cites W1979585972 @default.
• W2763141254 cites W1979668851 @default.
• W2763141254 cites W1980067834 @default.
• W2763141254 cites W1980345326 @default.
• W2763141254 cites W1980572685 @default.
• W2763141254 cites W1983895037 @default.
• W2763141254 cites W1984910602 @default.
• W2763141254 cites W1986771106 @default.
• W2763141254 cites W1988427835 @default.
• W2763141254 cites W1989507734 @default.
• W2763141254 cites W1989677298 @default.
• W2763141254 cites W1989872754 @default.
• W2763141254 cites W1990208536 @default.
• W2763141254 cites W1990741847 @default.
• W2763141254 cites W1991325582 @default.
• W2763141254 cites W1993163519 @default.
• W2763141254 cites W1993833123 @default.
• W2763141254 cites W1996326344 @default.
• W2763141254 cites W1996793462 @default.
• W2763141254 cites W1998107315 @default.
• W2763141254 cites W1998143408 @default.
• W2763141254 cites W1998398302 @default.
• W2763141254 cites W2001676296 @default.
• W2763141254 cites W2003359121 @default.
• W2763141254 cites W2004490449 @default.
• W2763141254 cites W2006738236 @default.
• W2763141254 cites W2007418371 @default.
• W2763141254 cites W2008636829 @default.
• W2763141254 cites W2010898742 @default.
• W2763141254 cites W2014349188 @default.
• W2763141254 cites W2014382949 @default.
• W2763141254 cites W2015120197 @default.
• W2763141254 cites W2015682235 @default.
• W2763141254 cites W2015779686 @default.
• W2763141254 cites W2016696595 @default.
• W2763141254 cites W2017240003 @default.
• W2763141254 cites W2017289279 @default.
• W2763141254 cites W2017291434 @default.
• W2763141254 cites W2020175162 @default.
• W2763141254 cites W2020317919 @default.
• W2763141254 cites W2021964281 @default.
• W2763141254 cites W2022285722 @default.
• W2763141254 cites W2023330907 @default.
• W2763141254 cites W2023799373 @default.
• W2763141254 cites W2024195902 @default.
• W2763141254 cites W2027322293 @default.
• W2763141254 cites W2028859875 @default.
• W2763141254 cites W2029197798 @default.
• W2763141254 cites W2031980384 @default.
• W2763141254 cites W2033660939 @default.
• W2763141254 cites W2034140557 @default.
• W2763141254 cites W2034340060 @default.

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