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- W2763231274 abstract "To review the current status of positron emission tomography (PET) molecular imaging research of levodopa-induced dyskinesias (LIDs) in Parkinson’s disease (PD). Recent PET studies have provided robust evidence that LIDs in PD are associated with elevated and fluctuating striatal dopamine synaptic levels, which is a consequence of the imbalance between dopaminergic and serotonergic terminals, with the latter playing a key role in mishandling presynaptic dopamine release. Long-term exposure to levodopa is no longer believed to solely induce LIDs, as studies have highlighted that PD patients who go on to develop LIDs exhibit elevated putaminal dopamine release before the initiation of levodopa treatment, suggesting the involvement of other mechanisms, including altered neuronal firing and abnormal levels of phosphodiesterase 10A. Dopaminergic, serotonergic, glutamatergic, adenosinergic and opioid systems and phosphodiesterase 10A levels have been shown to be implicated in the development of LIDs in PD. However, no system may be considered sufficient on its own for the development of LIDs, and the mechanisms underlying LIDs in PD may have a multisystem origin. In line with this notion, future studies should use multimodal PET molecular imaging in the same individuals to shed further light on the different mechanisms underlying the development of LIDs in PD." @default.
- W2763231274 created "2017-10-20" @default.
- W2763231274 creator A5015136173 @default.
- W2763231274 creator A5038003785 @default.
- W2763231274 creator A5048882944 @default.
- W2763231274 date "2017-10-03" @default.
- W2763231274 modified "2023-09-24" @default.
- W2763231274 title "PET Molecular Imaging Research of Levodopa-Induced Dyskinesias in Parkinson’s Disease" @default.
- W2763231274 cites W150004070 @default.
- W2763231274 cites W1533056363 @default.
- W2763231274 cites W1734672092 @default.
- W2763231274 cites W1913103036 @default.
- W2763231274 cites W1965030220 @default.
- W2763231274 cites W1967560516 @default.
- W2763231274 cites W1971000963 @default.
- W2763231274 cites W1974878974 @default.
- W2763231274 cites W1977687697 @default.
- W2763231274 cites W1979446415 @default.
- W2763231274 cites W1980065838 @default.
- W2763231274 cites W1981123646 @default.
- W2763231274 cites W1981860915 @default.
- W2763231274 cites W1986626488 @default.
- W2763231274 cites W1988664274 @default.
- W2763231274 cites W1992428237 @default.
- W2763231274 cites W1996506764 @default.
- W2763231274 cites W2006518723 @default.
- W2763231274 cites W2011717274 @default.
- W2763231274 cites W2012814200 @default.
- W2763231274 cites W2017083073 @default.
- W2763231274 cites W2017297186 @default.
- W2763231274 cites W2017688838 @default.
- W2763231274 cites W2027496660 @default.
- W2763231274 cites W2028911868 @default.
- W2763231274 cites W2029310204 @default.
- W2763231274 cites W2029942338 @default.
- W2763231274 cites W2030108063 @default.
- W2763231274 cites W2032639611 @default.
- W2763231274 cites W2032777075 @default.
- W2763231274 cites W2033092161 @default.
- W2763231274 cites W2037741322 @default.
- W2763231274 cites W2037811574 @default.
- W2763231274 cites W2038310981 @default.
- W2763231274 cites W2039194913 @default.
- W2763231274 cites W2043235067 @default.
- W2763231274 cites W2044565330 @default.
- W2763231274 cites W2045338633 @default.
- W2763231274 cites W2046079803 @default.
- W2763231274 cites W2052737428 @default.
- W2763231274 cites W2053853927 @default.
- W2763231274 cites W2053877581 @default.
- W2763231274 cites W2054281268 @default.
- W2763231274 cites W2061978580 @default.
- W2763231274 cites W2065015313 @default.
- W2763231274 cites W2071128734 @default.
- W2763231274 cites W2072308972 @default.
- W2763231274 cites W2072586173 @default.
- W2763231274 cites W2073196506 @default.
- W2763231274 cites W2074865886 @default.
- W2763231274 cites W2076889177 @default.
- W2763231274 cites W2076944909 @default.
- W2763231274 cites W2084621653 @default.
- W2763231274 cites W2087062737 @default.
- W2763231274 cites W2094238617 @default.
- W2763231274 cites W2096643782 @default.
- W2763231274 cites W2096898998 @default.
- W2763231274 cites W2098783607 @default.
- W2763231274 cites W2106108170 @default.
- W2763231274 cites W2106158259 @default.
- W2763231274 cites W2115222037 @default.
- W2763231274 cites W2115639304 @default.
- W2763231274 cites W2117795088 @default.
- W2763231274 cites W2118021908 @default.
- W2763231274 cites W2128726475 @default.
- W2763231274 cites W2132551489 @default.
- W2763231274 cites W2133697996 @default.
- W2763231274 cites W2136018016 @default.
- W2763231274 cites W2138389486 @default.
- W2763231274 cites W2140235984 @default.
- W2763231274 cites W2140463558 @default.
- W2763231274 cites W2152316935 @default.
- W2763231274 cites W2153607988 @default.
- W2763231274 cites W2159045156 @default.
- W2763231274 cites W2164426353 @default.
- W2763231274 cites W2165367055 @default.
- W2763231274 cites W2168161132 @default.
- W2763231274 cites W2169396775 @default.
- W2763231274 cites W2170781893 @default.
- W2763231274 cites W2200046214 @default.
- W2763231274 cites W2232279739 @default.
- W2763231274 cites W2274630109 @default.
- W2763231274 cites W2285237309 @default.
- W2763231274 cites W2286928966 @default.
- W2763231274 cites W2298359827 @default.
- W2763231274 cites W2317320755 @default.
- W2763231274 cites W2337142316 @default.
- W2763231274 cites W2437948583 @default.
- W2763231274 cites W2549997522 @default.
- W2763231274 cites W2560490590 @default.
- W2763231274 cites W2595101472 @default.
- W2763231274 cites W2607249543 @default.