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- W2763294219 abstract "IL-37 is a member of the IL-1 family, but unlike most other members of this family of cytokines, it has wide-ranging anti-inflammatory properties. Initially shown to bind IL-18 binding protein and prevent IL-18-mediated inflammation, its known role has been expanded to include distinct pathways, both intracellular involving the transcription factor Smad3, and extracellular via binding to the orphan receptor IL-1R8. A number of recent publications investigating the role of IL-37 in atherosclerosis and ischemic heart disease have revealed promising therapeutic value of the cytokine. Although research concerning the role of IL-37 and its mechanism in atherosclerosis is relatively scant, there are a number of well-known atherosclerotic processes that this cytokine can mediate with the potential of modulating the disease progression itself. This review will probe in detail the effects of IL-37 on important pathological processes such as inflammation, dysregulated lipid metabolism, and apoptosis, by analyzing existing data as well as exploring the potential of this cytokine to influence these properties." @default.
- W2763294219 created "2017-10-20" @default.
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- W2763294219 creator A5042620758 @default.
- W2763294219 creator A5047688596 @default.
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- W2763294219 date "2019-10-01" @default.
- W2763294219 modified "2023-10-13" @default.
- W2763294219 title "Potential role of IL-37 in atherosclerosis" @default.
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- W2763294219 doi "https://doi.org/10.1016/j.cyto.2017.09.025" @default.
- W2763294219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5886822" @default.
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- W2763294219 hasPublicationYear "2019" @default.
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