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- W2763322182 endingPage "134" @default.
- W2763322182 startingPage "98" @default.
- W2763322182 abstract "Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases a prerequisite to sustain tumor development and progression. Like protein kinases, protein phosphatases are key regulators of cell signaling. However, their contribution to aberrant signaling in cancer cells is overall less well appreciated, and therefore, their clinical potential remains largely unexploited. In this review, we provide an overview of tumor suppressive protein phosphatases in human cancer. Along their mechanisms of inactivation in defined cancer contexts, we give an overview of their functional roles in diverse signaling pathways that contribute to their tumor suppressive abilities. Finally, we discuss their emerging roles as predictive or prognostic markers, their potential as synthetic lethality targets, and the current feasibility of their reactivation with pharmacologic compounds as promising new cancer therapies. We conclude that their inclusion in clinical practice has obvious potential to significantly improve therapeutic outcome in various ways, and should now definitely be pushed forward." @default.
- W2763322182 created "2017-10-20" @default.
- W2763322182 creator A5021024165 @default.
- W2763322182 creator A5052092471 @default.
- W2763322182 date "2018-03-01" @default.
- W2763322182 modified "2023-10-13" @default.
- W2763322182 title "Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification" @default.
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