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- W2763433312 abstract "Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as positive mediators of apoptosis via extrinsic and intrinsic death-regulating signaling pathways. Tumor suppressor activities have been shown for DAPk1 and DAPk2 and they are downregulated in e.g., Hodgkin’s (HL) and B cell lymphoma (CLL), respectively. Here, we review a targeted therapeutic approach which involves reconstitution of DAPks by the generation of immunokinase fusion proteins. These recombinant proteins consist of a disease-specific ligand fused to a modified version of DAPk1 or DAPk2. HL was targeted via CD30 and B-CLL via CD22 cell surface antigens." @default.
- W2763433312 created "2017-10-20" @default.
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- W2763433312 creator A5090840055 @default.
- W2763433312 date "2017-10-04" @default.
- W2763433312 modified "2023-10-06" @default.
- W2763433312 title "Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins" @default.
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- W2763433312 cites W1563458559 @default.
- W2763433312 cites W1639943679 @default.
- W2763433312 cites W1717397784 @default.
- W2763433312 cites W1804201762 @default.
- W2763433312 cites W1890387809 @default.
- W2763433312 cites W1924090634 @default.
- W2763433312 cites W1966134982 @default.
- W2763433312 cites W1966981147 @default.
- W2763433312 cites W1971188778 @default.
- W2763433312 cites W1981720385 @default.
- W2763433312 cites W1983719963 @default.
- W2763433312 cites W1984888383 @default.
- W2763433312 cites W1987579092 @default.
- W2763433312 cites W1992544868 @default.
- W2763433312 cites W1994214112 @default.
- W2763433312 cites W1994411647 @default.
- W2763433312 cites W1997333958 @default.
- W2763433312 cites W2008757142 @default.
- W2763433312 cites W2010323640 @default.
- W2763433312 cites W2012433276 @default.
- W2763433312 cites W2014501359 @default.
- W2763433312 cites W2015604066 @default.
- W2763433312 cites W2017364444 @default.
- W2763433312 cites W2020180668 @default.
- W2763433312 cites W2029295361 @default.
- W2763433312 cites W2030115507 @default.
- W2763433312 cites W2041329507 @default.
- W2763433312 cites W2044831576 @default.
- W2763433312 cites W2047509412 @default.
- W2763433312 cites W2047847939 @default.
- W2763433312 cites W2051495929 @default.
- W2763433312 cites W2052730401 @default.
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- W2763433312 cites W2063367334 @default.
- W2763433312 cites W2066894862 @default.
- W2763433312 cites W2077483015 @default.
- W2763433312 cites W2086150419 @default.
- W2763433312 cites W2088359515 @default.
- W2763433312 cites W2088720202 @default.
- W2763433312 cites W2093207749 @default.
- W2763433312 cites W2093823051 @default.
- W2763433312 cites W2095515726 @default.
- W2763433312 cites W2097026238 @default.
- W2763433312 cites W2099818615 @default.
- W2763433312 cites W2103067815 @default.
- W2763433312 cites W2103696805 @default.
- W2763433312 cites W2104592618 @default.
- W2763433312 cites W2109684867 @default.
- W2763433312 cites W2110396375 @default.
- W2763433312 cites W2111233859 @default.
- W2763433312 cites W2111599440 @default.
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- W2763433312 cites W2145923454 @default.
- W2763433312 cites W2146969546 @default.
- W2763433312 cites W2152712144 @default.
- W2763433312 cites W2154594687 @default.
- W2763433312 cites W2154799239 @default.
- W2763433312 cites W2156044891 @default.
- W2763433312 cites W2156320420 @default.
- W2763433312 cites W2161784983 @default.
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- W2763433312 cites W2167020999 @default.
- W2763433312 cites W2168041368 @default.
- W2763433312 cites W2168194093 @default.
- W2763433312 cites W2171128065 @default.
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- W2763433312 doi "https://doi.org/10.3390/biomedicines5040059" @default.
- W2763433312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5744083" @default.
- W2763433312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28976934" @default.
- W2763433312 hasPublicationYear "2017" @default.
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