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• W2763440710 abstract "// Qi Ding 1, 3 , Gao-Qin Liu 2 , Yuan-Yuan Zeng 1 , Jian-Jie Zhu 1 , Ze-Yi Liu 1 , Xueguang Zhang 2 and Jian-An Huang 1, 2 1 Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China 2 Clinical Immunology Laboratory of Jiangsu Province, Suzhou 215006, China 3 Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215006, China Correspondence to: Jian-An Huang, email: syringa2015@sina.com Keywords: IL-17, acute respiratory distress syndrome, acute lung injury, RORγt, PI3K pathway Received: June 28, 2017      Accepted: September 20, 2017      Published: October 04, 2017 ABSTRACT To assess the clinical significance of IL-17 in patients with sepsis-induced acute respiratory distress syndrome (ARDS) and to investigate the effects of IL-17 blocking in a mouse model of acute lung injury (ALI). Significantly increased IL-17 level was found in patients with sepsis-related ARDS compared to healthy controls, whereas significantly increased plasma IL-17 level was also observed in non-survivors compared to that in survivors. According to the data from the mouse ALI model, we found significantly increased IL-17 level in lung tissue lysates, mouse bronchoalveolar lavage fluid (mBALF) and plasma at 6, 12 and 24 h after ALI. Histological analyses revealed that reduced sign of pathological changes and lung injury score in the lungs at 48 h after IL-17 blocking antibody administration. Reduced level of proinflammatory tumor necrosis factor α and increased level of anti-inflammatory factor interleukin-10 were found in both mBALF and plasma. Moreover, IL-17 blocking antibody administration attenuated the expression of RORγt and activity of PI3K-Akt pathway. Increased IL-17 was presented in patients with sepsis-induced ARDS and IL-17 may serve as a biomarker to indicate the severity of ARDS. Moreover, IL-17 antibody administration could relieve the ALI symptom by affecting RORγt level and PI3K pathway." @default.
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• W2763440710 date "2017-10-04" @default.
• W2763440710 modified "2023-09-30" @default.
• W2763440710 title "Role of IL-17 in LPS-induced acute lung injury: an <i>in vivo</i> study" @default.
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• W2763440710 doi "https://doi.org/10.18632/oncotarget.21474" @default.
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