Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763558051> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2763558051 abstract "Zidovudine is chemically known as 1-(3-Azido-2, 3-dideoxy-beta-Dribofuranosyl) thymine and is the first approved treatment for HIV and is included in world health organization essential drug list. Zidovudine that is also termed as azidothymidine (AZA), is a nucleoside analog reverse transcriptor inhibitor (NRTI) and is a kind of antiretroviral drug for the treatment of human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS). Methyl methanesulfonate is a know genotoxic impurity and is potential process impurity of zidovudine. The method development and subsequent validation activity was done for the analysis of methyl methanesulfonate (MMS) in zidovudine drug substance. The development activity was conducted by gas chromatography technique with mass spectrometer as detector. Capillary column used in the method was Rtx-1301, with length 60 meter, internal diameter 0.25mm, filmthickness 0.25 µm with helium as carrier gas. Validation of the method is conducted based on international conference on harmonization (ICH) guidelines. The LOD and LOQ values are found to be 0.04 and 0.12 µg/g (i.e. 0.004 and 0.012 µg/mL) respectively for MMS." @default.
- W2763558051 created "2017-10-20" @default.
- W2763558051 creator A5002623438 @default.
- W2763558051 creator A5081709752 @default.
- W2763558051 creator A5083871967 @default.
- W2763558051 date "2015-01-01" @default.
- W2763558051 modified "2023-09-23" @default.
- W2763558051 title "Genotoxic impurity method development and validation by GCMS for the analysis of methyl methane sulfonate (MMS) in Zidovudine drug substance" @default.
- W2763558051 hasPublicationYear "2015" @default.
- W2763558051 type Work @default.
- W2763558051 sameAs 2763558051 @default.
- W2763558051 citedByCount "0" @default.
- W2763558051 crossrefType "journal-article" @default.
- W2763558051 hasAuthorship W2763558051A5002623438 @default.
- W2763558051 hasAuthorship W2763558051A5081709752 @default.
- W2763558051 hasAuthorship W2763558051A5083871967 @default.
- W2763558051 hasConcept C104317684 @default.
- W2763558051 hasConcept C123460561 @default.
- W2763558051 hasConcept C143065580 @default.
- W2763558051 hasConcept C159047783 @default.
- W2763558051 hasConcept C185592680 @default.
- W2763558051 hasConcept C2780035454 @default.
- W2763558051 hasConcept C2780216070 @default.
- W2763558051 hasConcept C2780727368 @default.
- W2763558051 hasConcept C3013748606 @default.
- W2763558051 hasConcept C3018250846 @default.
- W2763558051 hasConcept C43617362 @default.
- W2763558051 hasConcept C55493867 @default.
- W2763558051 hasConcept C71924100 @default.
- W2763558051 hasConcept C98274493 @default.
- W2763558051 hasConceptScore W2763558051C104317684 @default.
- W2763558051 hasConceptScore W2763558051C123460561 @default.
- W2763558051 hasConceptScore W2763558051C143065580 @default.
- W2763558051 hasConceptScore W2763558051C159047783 @default.
- W2763558051 hasConceptScore W2763558051C185592680 @default.
- W2763558051 hasConceptScore W2763558051C2780035454 @default.
- W2763558051 hasConceptScore W2763558051C2780216070 @default.
- W2763558051 hasConceptScore W2763558051C2780727368 @default.
- W2763558051 hasConceptScore W2763558051C3013748606 @default.
- W2763558051 hasConceptScore W2763558051C3018250846 @default.
- W2763558051 hasConceptScore W2763558051C43617362 @default.
- W2763558051 hasConceptScore W2763558051C55493867 @default.
- W2763558051 hasConceptScore W2763558051C71924100 @default.
- W2763558051 hasConceptScore W2763558051C98274493 @default.
- W2763558051 hasIssue "5" @default.
- W2763558051 hasLocation W27635580511 @default.
- W2763558051 hasOpenAccess W2763558051 @default.
- W2763558051 hasPrimaryLocation W27635580511 @default.
- W2763558051 hasRelatedWork W1952983142 @default.
- W2763558051 hasRelatedWork W1988851854 @default.
- W2763558051 hasRelatedWork W1998442048 @default.
- W2763558051 hasRelatedWork W2007509278 @default.
- W2763558051 hasRelatedWork W2014196545 @default.
- W2763558051 hasRelatedWork W2134335557 @default.
- W2763558051 hasRelatedWork W2184398552 @default.
- W2763558051 hasRelatedWork W2347976239 @default.
- W2763558051 hasRelatedWork W2368478079 @default.
- W2763558051 hasRelatedWork W2378692649 @default.
- W2763558051 hasRelatedWork W2381992250 @default.
- W2763558051 hasRelatedWork W2382756354 @default.
- W2763558051 hasRelatedWork W2383346214 @default.
- W2763558051 hasRelatedWork W2416750701 @default.
- W2763558051 hasRelatedWork W2481664921 @default.
- W2763558051 hasRelatedWork W2601150777 @default.
- W2763558051 hasRelatedWork W2890699939 @default.
- W2763558051 hasRelatedWork W3024742256 @default.
- W2763558051 hasRelatedWork W3133163939 @default.
- W2763558051 hasRelatedWork W3208991345 @default.
- W2763558051 hasVolume "15" @default.
- W2763558051 isParatext "false" @default.
- W2763558051 isRetracted "false" @default.
- W2763558051 magId "2763558051" @default.
- W2763558051 workType "article" @default.