Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763727619> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2763727619 abstract "In order to clone the peafowl (Pavo cristatus) Toll-like receptor 7 (TLR7) gene and study its biological function, the peafowl TLR7 coding sequences (CDS) were amplified by PCR of cDNA from the whole spleen of peafowl. The full-length sequence of the peafowl TLR7 gene CDS is 3,141 bp and encodes a 1,046-amino acid protein with a classic TLR composition of 16 leucine-rich repeats (LRR). Insertions of amino acids were found at position 15 of LRR2, LRR5, LRR7, LRR9, LRR11, LRR12, LRR14, and LRR15; and position 10 of LRR11. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis showed that the peafowl TLR7 gene was highly expressed in lymphoid tissues of the spleen, bursa, bone marrow, lung, and peripheral blood mononuclear cells (PBMC). HEK293T cells were transfected with a peafowl TLR7 plasmid, and functional analysis showed that peafowl TLR7 could respond to R848, leading to activation of NF-κB. Following R848 stimulation or Newcastle disease virus infection of peafowl PBMC, the levels of IL-1β, IFN-γ, CCLi2, and TGF-β4 mRNA, assessed by quantitative real-time PCR, increased significantly. Triggering peafowl TLR7 results in upregulation of inflammatory cytokines and chemokines, suggesting that peafowl TLR7 plays an important role in the innate immune response." @default.
- W2763727619 created "2017-10-20" @default.
- W2763727619 creator A5000806510 @default.
- W2763727619 creator A5037301577 @default.
- W2763727619 creator A5061068278 @default.
- W2763727619 creator A5086249651 @default.
- W2763727619 creator A5086422471 @default.
- W2763727619 date "2018-01-01" @default.
- W2763727619 modified "2023-09-24" @default.
- W2763727619 title "Molecular cloning and functional analysis of peafowl (Pavo cristatus) Toll-like receptor 7" @default.
- W2763727619 cites W1525912444 @default.
- W2763727619 cites W1966892322 @default.
- W2763727619 cites W1967751929 @default.
- W2763727619 cites W1982850304 @default.
- W2763727619 cites W1995744610 @default.
- W2763727619 cites W2004465286 @default.
- W2763727619 cites W2004773897 @default.
- W2763727619 cites W2008426702 @default.
- W2763727619 cites W2019362508 @default.
- W2763727619 cites W2027983878 @default.
- W2763727619 cites W2040112602 @default.
- W2763727619 cites W2040174784 @default.
- W2763727619 cites W2042436346 @default.
- W2763727619 cites W2075623297 @default.
- W2763727619 cites W2085313087 @default.
- W2763727619 cites W2094098322 @default.
- W2763727619 cites W2101363646 @default.
- W2763727619 cites W2104424691 @default.
- W2763727619 cites W2119293746 @default.
- W2763727619 cites W2151098350 @default.
- W2763727619 cites W2154712398 @default.
- W2763727619 cites W2163860607 @default.
- W2763727619 cites W2171771275 @default.
- W2763727619 cites W2460044542 @default.
- W2763727619 doi "https://doi.org/10.3382/ps/pex286" @default.
- W2763727619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29053867" @default.
- W2763727619 hasPublicationYear "2018" @default.
- W2763727619 type Work @default.
- W2763727619 sameAs 2763727619 @default.
- W2763727619 citedByCount "0" @default.
- W2763727619 crossrefType "journal-article" @default.
- W2763727619 hasAuthorship W2763727619A5000806510 @default.
- W2763727619 hasAuthorship W2763727619A5037301577 @default.
- W2763727619 hasAuthorship W2763727619A5061068278 @default.
- W2763727619 hasAuthorship W2763727619A5086249651 @default.
- W2763727619 hasAuthorship W2763727619A5086422471 @default.
- W2763727619 hasBestOaLocation W27637276191 @default.
- W2763727619 hasConcept C104317684 @default.
- W2763727619 hasConcept C136449434 @default.
- W2763727619 hasConcept C153911025 @default.
- W2763727619 hasConcept C187882448 @default.
- W2763727619 hasConcept C2776709828 @default.
- W2763727619 hasConcept C2779836521 @default.
- W2763727619 hasConcept C54355233 @default.
- W2763727619 hasConcept C86803240 @default.
- W2763727619 hasConcept C8891405 @default.
- W2763727619 hasConceptScore W2763727619C104317684 @default.
- W2763727619 hasConceptScore W2763727619C136449434 @default.
- W2763727619 hasConceptScore W2763727619C153911025 @default.
- W2763727619 hasConceptScore W2763727619C187882448 @default.
- W2763727619 hasConceptScore W2763727619C2776709828 @default.
- W2763727619 hasConceptScore W2763727619C2779836521 @default.
- W2763727619 hasConceptScore W2763727619C54355233 @default.
- W2763727619 hasConceptScore W2763727619C86803240 @default.
- W2763727619 hasConceptScore W2763727619C8891405 @default.
- W2763727619 hasFunder F4320321001 @default.
- W2763727619 hasLocation W27637276191 @default.
- W2763727619 hasLocation W27637276192 @default.
- W2763727619 hasOpenAccess W2763727619 @default.
- W2763727619 hasPrimaryLocation W27637276191 @default.
- W2763727619 hasRelatedWork W137894342 @default.
- W2763727619 hasRelatedWork W1491667086 @default.
- W2763727619 hasRelatedWork W1542392557 @default.
- W2763727619 hasRelatedWork W1969072247 @default.
- W2763727619 hasRelatedWork W1977920180 @default.
- W2763727619 hasRelatedWork W1994391392 @default.
- W2763727619 hasRelatedWork W1999894089 @default.
- W2763727619 hasRelatedWork W2040503769 @default.
- W2763727619 hasRelatedWork W2095253215 @default.
- W2763727619 hasRelatedWork W2159308067 @default.
- W2763727619 isParatext "false" @default.
- W2763727619 isRetracted "false" @default.
- W2763727619 magId "2763727619" @default.
- W2763727619 workType "article" @default.