Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763734362> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2763734362 endingPage "503" @default.
- W2763734362 startingPage "498" @default.
- W2763734362 abstract "Current treatment against medulloblastoma, one of the most frequent tumors in childhood and early adolescence, is not effective enough, presenting long time relapses in addition to side effects in growth and intellectual outcome of patients. Among the different types of medulloblastoma, we focused on the sonic hedgehog (Shh) type of this disease. Cyclopamine inhibits the Shh pathway. Medulloblastoma very often presents chemotherapy resistance. We tried, in this work to understand the mechanism of cyclopamine resistance in Shh meduloblastoma. In our study we induced cyclopamine resistance to Daoy desmoplastic Shh type medulloblastoma cells by treating them with this drug for a long period of time. Cellular assays (proliferation, clonogenicity, and migration), together with qRT-PCR molecular experiments allowed us to verify the different behaviour of the cells after each cyclopamine exposure. The results highlight the evidence that cells became resistant because they were able to grow in soft agar without attachment, to migrate and to overexpress genes related to cancer stem-like cell phenotypes. The resistance induced seems to have a cyclic behaviour, as according with the results Daoy cells might sustain a subgroup of cancer stem-like cells in the tumor that never disappear despite cyclopamine treatments. Induction of cyclopamine resistance in desmoplastic Shh medulloblastoma cells increases their cancer stem-like cell compartment and their in vitro tumorigenic potential. Further studies are required to properly understand the mechanisms of cyclopamine resistance and the possible ways to overcome it." @default.
- W2763734362 created "2017-10-20" @default.
- W2763734362 creator A5007859367 @default.
- W2763734362 creator A5015810342 @default.
- W2763734362 creator A5065875902 @default.
- W2763734362 creator A5072478701 @default.
- W2763734362 creator A5081810190 @default.
- W2763734362 creator A5089052993 @default.
- W2763734362 date "2017-09-29" @default.
- W2763734362 modified "2023-10-03" @default.
- W2763734362 title "Induction of cyclopamine resistance in desmoplastic medulloblastoma cells increases their cancer stem-like cell compartment and their in vitro tumorigenic potential" @default.
- W2763734362 hasPublicationYear "2017" @default.
- W2763734362 type Work @default.
- W2763734362 sameAs 2763734362 @default.
- W2763734362 citedByCount "0" @default.
- W2763734362 crossrefType "journal-article" @default.
- W2763734362 hasAuthorship W2763734362A5007859367 @default.
- W2763734362 hasAuthorship W2763734362A5015810342 @default.
- W2763734362 hasAuthorship W2763734362A5065875902 @default.
- W2763734362 hasAuthorship W2763734362A5072478701 @default.
- W2763734362 hasAuthorship W2763734362A5081810190 @default.
- W2763734362 hasAuthorship W2763734362A5089052993 @default.
- W2763734362 hasConcept C121608353 @default.
- W2763734362 hasConcept C2776637008 @default.
- W2763734362 hasConcept C2777605378 @default.
- W2763734362 hasConcept C2780789225 @default.
- W2763734362 hasConcept C28328180 @default.
- W2763734362 hasConcept C502942594 @default.
- W2763734362 hasConcept C54355233 @default.
- W2763734362 hasConcept C55427017 @default.
- W2763734362 hasConcept C62478195 @default.
- W2763734362 hasConcept C86803240 @default.
- W2763734362 hasConcept C88498014 @default.
- W2763734362 hasConcept C95444343 @default.
- W2763734362 hasConcept C96232424 @default.
- W2763734362 hasConceptScore W2763734362C121608353 @default.
- W2763734362 hasConceptScore W2763734362C2776637008 @default.
- W2763734362 hasConceptScore W2763734362C2777605378 @default.
- W2763734362 hasConceptScore W2763734362C2780789225 @default.
- W2763734362 hasConceptScore W2763734362C28328180 @default.
- W2763734362 hasConceptScore W2763734362C502942594 @default.
- W2763734362 hasConceptScore W2763734362C54355233 @default.
- W2763734362 hasConceptScore W2763734362C55427017 @default.
- W2763734362 hasConceptScore W2763734362C62478195 @default.
- W2763734362 hasConceptScore W2763734362C86803240 @default.
- W2763734362 hasConceptScore W2763734362C88498014 @default.
- W2763734362 hasConceptScore W2763734362C95444343 @default.
- W2763734362 hasConceptScore W2763734362C96232424 @default.
- W2763734362 hasOpenAccess W2763734362 @default.
- W2763734362 hasRelatedWork W1546669442 @default.
- W2763734362 hasRelatedWork W165076036 @default.
- W2763734362 hasRelatedWork W1810165063 @default.
- W2763734362 hasRelatedWork W1864887926 @default.
- W2763734362 hasRelatedWork W2001845064 @default.
- W2763734362 hasRelatedWork W2015189241 @default.
- W2763734362 hasRelatedWork W2025872085 @default.
- W2763734362 hasRelatedWork W2106395966 @default.
- W2763734362 hasRelatedWork W2171506563 @default.
- W2763734362 hasRelatedWork W2322904320 @default.
- W2763734362 hasRelatedWork W2345194485 @default.
- W2763734362 hasRelatedWork W2562721897 @default.
- W2763734362 hasRelatedWork W3092292809 @default.
- W2763734362 hasRelatedWork W3129822289 @default.
- W2763734362 hasRelatedWork W3200827662 @default.
- W2763734362 hasRelatedWork W32457357 @default.
- W2763734362 hasRelatedWork W44679503 @default.
- W2763734362 hasRelatedWork W574904037 @default.
- W2763734362 hasRelatedWork W933087622 @default.
- W2763734362 hasRelatedWork W1914187208 @default.
- W2763734362 hasVolume "5" @default.
- W2763734362 isParatext "false" @default.
- W2763734362 isRetracted "false" @default.
- W2763734362 magId "2763734362" @default.
- W2763734362 workType "article" @default.