FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763762909> ?p ?o ?g. }

• W2763762909 abstract "Left ventricular (LV) hypertrophy, highest in prevalence among African Americans, is an established risk factor heart failure. Several genome wide association studies have identified common variants associated with LV-related quantitative-traits in African Americans. To date, however, the effect of rare variants on these traits has not been extensively studied, especially in minority groups. We therefore investigated the association between rare variants and LV traits among 1,934 African Americans using exome chip data from the Hypertension Genetic Epidemiology Network (HyperGEN) study, with replication in 1,090 African American from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. We used single-variant analyses and gene-based tests to investigate the association between 86,927 variants and six structural and functional LV traits including LV mass, LV internal dimension-diastole, relative wall thickness, left atrial dimension (LAD), fractional shortening (FS), and the ratio of LV early-to-late transmitral velocity (E/A ratio). Only rare variants (MAF <1% and <5%) were considered in gene-based analyses. In gene-based analyses, we found a statistically significant association between potassium voltage-gated channel subfamily H member 4 (KCNH4) and E/A ratio (P=8.7*10-8 using a burden test). Endonuclease G (ENDOG) was associated with LAD using the Madsen Browning weighted burden (MB) test (P=1.4*10-7). Neither gene result was replicated in GENOA, but the direction of effect of single variants in common was comparable. G protein-coupled receptor 55 (GPR55) was marginally associated with LAD in HyperGEN (P=3.2*10-5 using the MB test) and E/A ratio in GENOA, but with opposing directions of association for variants in common (P=0.03 for the MB test). No single variant was statistically significantly associated with any trait after correcting for multiple testing. The findings in this study highlight the potential cumulative contributions of rare variants to LV traits which, if validated, could improve our understanding of heart failure in African Americans." @default.
• W2763762909 created "2017-10-20" @default.
• W2763762909 creator A5002505667 @default.
• W2763762909 creator A5016218265 @default.
• W2763762909 creator A5019496348 @default.
• W2763762909 creator A5039456429 @default.
• W2763762909 creator A5056150005 @default.
• W2763762909 creator A5067586446 @default.
• W2763762909 creator A5069430086 @default.
• W2763762909 creator A5072618757 @default.
• W2763762909 creator A5073531688 @default.
• W2763762909 creator A5074613624 @default.
• W2763762909 creator A5075452580 @default.
• W2763762909 creator A5079359230 @default.
• W2763762909 creator A5079771081 @default.
• W2763762909 creator A5080338655 @default.
• W2763762909 creator A5086557925 @default.
• W2763762909 creator A5089259667 @default.
• W2763762909 date "2017-12-31" @default.
• W2763762909 modified "2023-09-27" @default.
• W2763762909 title "Whole Exome Analyses to Examine the Impact of Rare Variants on Left Ventricular Traits in African American Participants from the HyperGEN and GENOA Studies" @default.
• W2763762909 cites W1496121141 @default.
• W2763762909 cites W1555420371 @default.
• W2763762909 cites W1602564106 @default.
• W2763762909 cites W1845358967 @default.
• W2763762909 cites W1973619956 @default.
• W2763762909 cites W1975925766 @default.
• W2763762909 cites W1976987687 @default.
• W2763762909 cites W1982609122 @default.
• W2763762909 cites W1984068087 @default.
• W2763762909 cites W1985194414 @default.
• W2763762909 cites W1990430353 @default.
• W2763762909 cites W1991531810 @default.
• W2763762909 cites W1997421859 @default.
• W2763762909 cites W2008510705 @default.
• W2763762909 cites W2010579338 @default.
• W2763762909 cites W2015064892 @default.
• W2763762909 cites W2015231103 @default.
• W2763762909 cites W2017850911 @default.
• W2763762909 cites W2019670633 @default.
• W2763762909 cites W2034292751 @default.
• W2763762909 cites W2050856345 @default.
• W2763762909 cites W2054521115 @default.
• W2763762909 cites W2059145105 @default.
• W2763762909 cites W2063365673 @default.
• W2763762909 cites W2063655230 @default.
• W2763762909 cites W2064635885 @default.
• W2763762909 cites W2070984858 @default.
• W2763762909 cites W2075797384 @default.
• W2763762909 cites W2077202038 @default.
• W2763762909 cites W2087097014 @default.
• W2763762909 cites W2093577499 @default.
• W2763762909 cites W2104960825 @default.
• W2763762909 cites W2108169091 @default.
• W2763762909 cites W2108691077 @default.
• W2763762909 cites W2109041435 @default.
• W2763762909 cites W2116223333 @default.
• W2763762909 cites W2116786571 @default.
• W2763762909 cites W2122492792 @default.
• W2763762909 cites W2126388596 @default.
• W2763762909 cites W2127154429 @default.
• W2763762909 cites W2128607388 @default.
• W2763762909 cites W2150199950 @default.
• W2763762909 cites W2161310038 @default.
• W2763762909 cites W2163953557 @default.
• W2763762909 cites W2482501744 @default.
• W2763762909 cites W2607290897 @default.
• W2763762909 cites W4211200033 @default.
• W2763762909 doi "https://doi.org/10.23937/2474-3690/1510025" @default.
• W2763762909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5831560" @default.
• W2763762909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29503979" @default.
• W2763762909 hasPublicationYear "2017" @default.
• W2763762909 type Work @default.
• W2763762909 sameAs 2763762909 @default.
• W2763762909 citedByCount "0" @default.
• W2763762909 crossrefType "journal-article" @default.
• W2763762909 hasAuthorship W2763762909A5002505667 @default.
• W2763762909 hasAuthorship W2763762909A5016218265 @default.
• W2763762909 hasAuthorship W2763762909A5019496348 @default.
• W2763762909 hasAuthorship W2763762909A5039456429 @default.
• W2763762909 hasAuthorship W2763762909A5056150005 @default.
• W2763762909 hasAuthorship W2763762909A5067586446 @default.
• W2763762909 hasAuthorship W2763762909A5069430086 @default.
• W2763762909 hasAuthorship W2763762909A5072618757 @default.
• W2763762909 hasAuthorship W2763762909A5073531688 @default.
• W2763762909 hasAuthorship W2763762909A5074613624 @default.
• W2763762909 hasAuthorship W2763762909A5075452580 @default.
• W2763762909 hasAuthorship W2763762909A5079359230 @default.
• W2763762909 hasAuthorship W2763762909A5079771081 @default.
• W2763762909 hasAuthorship W2763762909A5080338655 @default.
• W2763762909 hasAuthorship W2763762909A5086557925 @default.
• W2763762909 hasAuthorship W2763762909A5089259667 @default.
• W2763762909 hasBestOaLocation W27637629091 @default.
• W2763762909 hasConcept C104317684 @default.
• W2763762909 hasConcept C10590036 @default.
• W2763762909 hasConcept C106208931 @default.
• W2763762909 hasConcept C107130276 @default.
• W2763762909 hasConcept C126322002 @default.
• W2763762909 hasConcept C127716648 @default.
• W2763762909 hasConcept C135763542 @default.

• next