FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763770159> ?p ?o ?g. }

• W2763770159 endingPage "94150" @default.
• W2763770159 startingPage "94142" @default.
• W2763770159 abstract "// Liang Cheng 1 , Tingxiang Chen 1 , Qiming Tu 1 , Hang Li 1 , Zhenghua Feng 1 , Zhijie Li 1 and Dingsheng Lin 1 1 Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China Correspondence to: Dingsheng Lin, email: lindingsheng@gmail.com Zhijie Li, email: lzhjwh@126.com Keywords: naringin, random flap survival, angiogenesis, inflammation, rat Received: July 28, 2017      Accepted: September 18, 2017      Published: October 06, 2017 ABSTRACT Background: Random-pattern flap transfer is commonly used to treat soft-tissue defects. However, flap necrosis remains a serious problem. Naringin accelerates angiogenesis by activating the expression of vascular endothelial growth factor (VEGF). In the present study, we investigated whether naringin improves the survival of random skin flaps. Results: Compared with controls, the naringin-treated groups exhibited significantly larger mean areas of flap survival, significantly increased SOD activity and VEGF expression, and significantly reduced MDA level. Hematoxylin and eosin (HE) staining revealed that naringin promoted angiogenesis and inhibited inflammation. Materials and Methods: “McFarlane flap” models were established in 90 male Sprague-Dawley (SD) rats divided into three groups: a 40 mg/kg control group (0.5 % sodium carboxymethylcellulose), a 40 mg/kg naringin-treated group, and an 80 mg/kg naringin-treated group. The extent of necrosis was measured 7 days later, and tissue samples were subjected to histological analysis. Angiogenesis was evaluated via lead oxide–gelatin angiography, immunohistochemistry, and laser Doppler imaging. Inflammation was evaluated by measurement of serum TNF-α (tumor necrosis factor-α) and IL-6 (interleukin-6) levels. Oxidative stress was assessed by measuring superoxide dismutase (SOD) activity and the malondialdehyde (MDA) level. Conclusion: Naringin improved random skin flap survival." @default.
• W2763770159 created "2017-10-20" @default.
• W2763770159 creator A5014953893 @default.
• W2763770159 creator A5015674482 @default.
• W2763770159 creator A5048811623 @default.
• W2763770159 creator A5050745569 @default.
• W2763770159 creator A5061178696 @default.
• W2763770159 creator A5086275760 @default.
• W2763770159 creator A5089060265 @default.
• W2763770159 date "2017-10-06" @default.
• W2763770159 modified "2023-10-17" @default.
• W2763770159 title "Naringin improves random skin flap survival in rats" @default.
• W2763770159 cites W1577847062 @default.
• W2763770159 cites W159632498 @default.
• W2763770159 cites W1965233215 @default.
• W2763770159 cites W1979696021 @default.
• W2763770159 cites W1989801597 @default.
• W2763770159 cites W2001230432 @default.
• W2763770159 cites W2011197306 @default.
• W2763770159 cites W2019344114 @default.
• W2763770159 cites W2023085770 @default.
• W2763770159 cites W2036661469 @default.
• W2763770159 cites W2036902108 @default.
• W2763770159 cites W2045677954 @default.
• W2763770159 cites W2048814988 @default.
• W2763770159 cites W2050960119 @default.
• W2763770159 cites W2051239278 @default.
• W2763770159 cites W2054811059 @default.
• W2763770159 cites W2055655375 @default.
• W2763770159 cites W2057568120 @default.
• W2763770159 cites W2063702062 @default.
• W2763770159 cites W2080331161 @default.
• W2763770159 cites W2084936401 @default.
• W2763770159 cites W2110177346 @default.
• W2763770159 cites W2135005509 @default.
• W2763770159 cites W2156075512 @default.
• W2763770159 cites W2157768596 @default.
• W2763770159 cites W2165803250 @default.
• W2763770159 cites W2196464755 @default.
• W2763770159 cites W2274030649 @default.
• W2763770159 cites W2302580454 @default.
• W2763770159 cites W2312937577 @default.
• W2763770159 cites W2327890497 @default.
• W2763770159 cites W2400592037 @default.
• W2763770159 cites W2409179589 @default.
• W2763770159 cites W2465816926 @default.
• W2763770159 cites W2553834282 @default.
• W2763770159 cites W2577202107 @default.
• W2763770159 cites W2728410653 @default.
• W2763770159 cites W4250413085 @default.
• W2763770159 cites W768948580 @default.
• W2763770159 cites W2120836480 @default.
• W2763770159 doi "https://doi.org/10.18632/oncotarget.21589" @default.
• W2763770159 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5706862" @default.
• W2763770159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29212216" @default.
• W2763770159 hasPublicationYear "2017" @default.
• W2763770159 type Work @default.
• W2763770159 sameAs 2763770159 @default.
• W2763770159 citedByCount "12" @default.
• W2763770159 countsByYear W27637701592018 @default.
• W2763770159 countsByYear W27637701592019 @default.
• W2763770159 countsByYear W27637701592020 @default.
• W2763770159 countsByYear W27637701592022 @default.
• W2763770159 countsByYear W27637701592023 @default.
• W2763770159 crossrefType "journal-article" @default.
• W2763770159 hasAuthorship W2763770159A5014953893 @default.
• W2763770159 hasAuthorship W2763770159A5015674482 @default.
• W2763770159 hasAuthorship W2763770159A5048811623 @default.
• W2763770159 hasAuthorship W2763770159A5050745569 @default.
• W2763770159 hasAuthorship W2763770159A5061178696 @default.
• W2763770159 hasAuthorship W2763770159A5086275760 @default.
• W2763770159 hasAuthorship W2763770159A5089060265 @default.
• W2763770159 hasBestOaLocation W27637701591 @default.
• W2763770159 hasConcept C125473707 @default.
• W2763770159 hasConcept C126322002 @default.
• W2763770159 hasConcept C141071460 @default.
• W2763770159 hasConcept C142724271 @default.
• W2763770159 hasConcept C185592680 @default.
• W2763770159 hasConcept C204232928 @default.
• W2763770159 hasConcept C2776914184 @default.
• W2763770159 hasConcept C2777335409 @default.
• W2763770159 hasConcept C2778271429 @default.
• W2763770159 hasConcept C2780394083 @default.
• W2763770159 hasConcept C43617362 @default.
• W2763770159 hasConcept C71924100 @default.
• W2763770159 hasConceptScore W2763770159C125473707 @default.
• W2763770159 hasConceptScore W2763770159C126322002 @default.
• W2763770159 hasConceptScore W2763770159C141071460 @default.
• W2763770159 hasConceptScore W2763770159C142724271 @default.
• W2763770159 hasConceptScore W2763770159C185592680 @default.
• W2763770159 hasConceptScore W2763770159C204232928 @default.
• W2763770159 hasConceptScore W2763770159C2776914184 @default.
• W2763770159 hasConceptScore W2763770159C2777335409 @default.
• W2763770159 hasConceptScore W2763770159C2778271429 @default.
• W2763770159 hasConceptScore W2763770159C2780394083 @default.
• W2763770159 hasConceptScore W2763770159C43617362 @default.
• W2763770159 hasConceptScore W2763770159C71924100 @default.
• W2763770159 hasIssue "55" @default.

• next