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• W2763814427 abstract "// Peng Chen 1, * , Min Fang 2, * , Qiuyan Wan 3 , Xuebang Zhang 4 , Tao Song 2 and Shixiu Wu 1 1 Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, Zhejiang, P. R. China 2 Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310000, Zhejiang, P. R. China 3 Department of Gynecologic Oncology, Jiangxi Cancer Hospital, Nanchang 330029, Jiangxi, P. R. China 4 Department of Radiation Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, P. R. China * These authors contributed equally to this work Correspondence to: Shixiu Wu, email: wushixiu@yeah.net , wushixiu@medmail.com.cn Keywords: esophageal squamous cell carcinoma, Glasgow prognostic score, prognostic factor, treatment response, survival Received: July 17, 2017      Accepted: September 21, 2017      Published: October 11, 2017 ABSTRACT The present study compared the prognostic value of the modified Glasgow prognostic score (mGPS) and high-sensitivity mGPS (HS-mGPS) in unresectable locally advanced esophageal squamous cell carcimona (LAESCC) patients treated with concurrent chemoradiotherapy (CCRT). The baseline data of 163 eligible patients were retrospectively collected. Patients with a C-reactive protein (CRP) ≤ 10 mg/l and albumin ≥ 35 g/l were allocated to mGPS-0 group. Patients with only elevated CRP (> 10 mg/l) were assigned to mGPS-1 group. Patients who had both elevated CRP (> 10 mg/l) and hypoalbuminurea (< 35 g/l) were assigned to mGPS-2 group. The HS-mGPS was calculated based on cutoff values of 3mg/l for CRP and the same value (35 g/l) for albumin. Prognostic significance for both tumor response and overall survival (OS) was analyzed by univariate and multivariate analysis. The mGPS was 0 in 95 patients, 1 in 28 patient and 2 in 40 patients. In contrast, the HS-mGPS was 0 in 66 patients, 1 in 47 patients and 2 in 50 patients. In multivariate analysis, the HS-mGPS was the only positive factor for tumor response ( P = 0.015). Both the mGPS ( P < 0.001) and HS-mGPS ( P < 0.001) were good prognostic predictors for OS. However, the HS-mGPS was found to be a superior prognostic predictor compared to the mGPS in a multivariate analysis ( P = 0.006). In conclusion, the pretreatment HS-mGPS is a strong prognosticator superior to the mGPS for both tumor response and OS in LAESCC patients who received CCRT." @default.
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• W2763814427 date "2017-10-11" @default.
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• W2763814427 title "High-sensitivity modified Glasgow prognostic score (HS-mGPS) Is superior to the mGPS in esophageal cancer patients treated with chemoradiotherapy" @default.
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• W2763814427 doi "https://doi.org/10.18632/oncotarget.21734" @default.
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