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• W2763817611 abstract "Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by phagocytosis and destruction of autoantibody-coated platelets via spleen tyrosine kinase (Syk)-mediated signal transduction in macrophages. Effectiveness of existing therapies varies, and even leading treatments (e.g., IVIg, splenectomy, rituximab, thrombopoietic agents) do not provide optimal management for a substantial number of patients with chronic ITP. Fostamatinib disodium is an orally-bioavailable investigational agent being developed for treatment of primary persistent/chronic adult ITP. Fostamatinib inhibits FcR-triggered, Syk-dependent cytoskeletal rearrangement during phagocytosis. Promising findings have been described in several autoimmune diseases, including rheumatoid arthritis, and sustained responses with manageable adverse events observed with ongoing treatment in patients with heavily treated chronic ITP. Fostamatinib represents an active therapy targeting a previously unexplored mechanism of ITP pathogenesis." @default.
• W2763817611 created "2017-10-20" @default.
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• W2763817611 date "2018-01-01" @default.
• W2763817611 modified "2023-10-13" @default.
• W2763817611 title "Fostamatinib for persistent/chronic adult immune thrombocytopenia" @default.
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• W2763817611 doi "https://doi.org/10.2217/imt-2017-0097" @default.
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