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- W2763851514 abstract "Objectives: Bacopa monnieri (BM), an ayurvedic medicinal plant, has attracted considerable interest owingto its diverse neuropharmacological properties. Epidemiological studies have shown significant correlationbetween paraquat (PQ) exposure and increased risk for Parkinson’s disease in humans. In this study, weexamined the propensity of standardized extract of BM to attenuate acute PQ-induced oxidative stress,mitochondrial dysfunctions, and neurotoxicity in the different brain regions of prepubertal mice.Methods: To test this hypothesis, prepubertal mice provided orally with standardized BM extract (200 mg/kgbody weight/day for 4 weeks) were challenged with an acute dose (15 mg/kg body weight, intraperitoneally)of PQ after 3 hours of last dose of extract. Mice were sacrificed after 48 hours of PQ injection, and differentbrain regions were isolated and subjected to biochemical determinations/quantification of centralmonoamine (dopamine, DA) levels (by high-performance liquid chromatography).Results: Oral supplementation of BM for 4 weeks resulted in significant reduction in the basal levels ofoxidative markers such as reactive oxygen species (ROS), malondialdehyde (MDA), and hydroperoxides(HP) in various brain regions. PQ at the administered dose elicited marked oxidative stress within 48 hoursin various brain regions of mice. However, BM prophylaxis significantly improved oxidative homeostasisby restoring PQ-induced ROS, MDA, and HP levels and also by attenuating mitochondrial dysfunction.Interestingly, BM supplementation restored the activities of cholinergic enzymes along with the restorationof striatal DA levels among the PQ-treated mice.Discussion: Based on these findings, we infer that BM prophylaxis renders the brain resistant to PQ-mediatedoxidative perturbations and thus may be better exploited as a preventive approach to protect againstoxidative-mediated neuronal dysfunctions" @default.
- W2763851514 created "2017-10-20" @default.
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- W2763851514 date "2014-01-01" @default.
- W2763851514 modified "2023-09-23" @default.
- W2763851514 title "Standardized Bacopa monnieri extractameliorates acute paraquat-induced oxidativestress, and neurotoxicity in prepubertal micebrain." @default.
- W2763851514 hasPublicationYear "2014" @default.
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