Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763859909> ?p ?o ?g. }
- W2763859909 abstract "We present a new, quantification-driven proteomic approach to identifying biomarkers. In contrast to the identification-driven approach, limited in scope to peptides that are identified by database searching in the first step, all MS data are considered to select biomarker candidates. The endopeptidome of cerebrospinal fluid from 40 Alzheimer's disease (AD) patients, 40 subjects with mild cognitive impairment, and 40 controls with subjective cognitive decline was analyzed using multiplex isobaric labeling. Spectral clustering was used to match MS/MS spectra. The top biomarker candidate cluster (215% higher in AD compared to controls, area under ROC curve = 0.96) was identified as a fragment of pleiotrophin located near the protein's C-terminus. Analysis of another cohort (n = 60 over four clinical groups) verified that the biomarker was increased in AD patients while no change in controls, Parkinson's disease or progressive supranuclear palsy was observed. The identification of the novel biomarker pleiotrophin 151-166 demonstrates that our quantification-driven proteomic approach is a promising method for biomarker discovery, which may be universally applicable in clinical proteomics." @default.
- W2763859909 created "2017-10-20" @default.
- W2763859909 creator A5003363891 @default.
- W2763859909 creator A5005557542 @default.
- W2763859909 creator A5024812828 @default.
- W2763859909 creator A5025313057 @default.
- W2763859909 creator A5025870220 @default.
- W2763859909 creator A5033539034 @default.
- W2763859909 creator A5038926287 @default.
- W2763859909 creator A5045343267 @default.
- W2763859909 creator A5048392322 @default.
- W2763859909 creator A5066503440 @default.
- W2763859909 creator A5075394738 @default.
- W2763859909 creator A5079766290 @default.
- W2763859909 creator A5080228220 @default.
- W2763859909 date "2017-10-17" @default.
- W2763859909 modified "2023-10-16" @default.
- W2763859909 title "A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease" @default.
- W2763859909 cites W1496097170 @default.
- W2763859909 cites W1560042780 @default.
- W2763859909 cites W1577433680 @default.
- W2763859909 cites W1582232587 @default.
- W2763859909 cites W1619957992 @default.
- W2763859909 cites W1781098768 @default.
- W2763859909 cites W1789413975 @default.
- W2763859909 cites W1968060950 @default.
- W2763859909 cites W1968176126 @default.
- W2763859909 cites W1969785535 @default.
- W2763859909 cites W1969832217 @default.
- W2763859909 cites W1970172743 @default.
- W2763859909 cites W1972982304 @default.
- W2763859909 cites W1974794668 @default.
- W2763859909 cites W1980314710 @default.
- W2763859909 cites W1984566266 @default.
- W2763859909 cites W1988146323 @default.
- W2763859909 cites W1992895077 @default.
- W2763859909 cites W1994591612 @default.
- W2763859909 cites W1994723621 @default.
- W2763859909 cites W2000798961 @default.
- W2763859909 cites W2003352316 @default.
- W2763859909 cites W2003463139 @default.
- W2763859909 cites W2006651878 @default.
- W2763859909 cites W2008827081 @default.
- W2763859909 cites W2010704344 @default.
- W2763859909 cites W2011503307 @default.
- W2763859909 cites W2013255353 @default.
- W2763859909 cites W2013536147 @default.
- W2763859909 cites W2015252529 @default.
- W2763859909 cites W2026465178 @default.
- W2763859909 cites W2028136664 @default.
- W2763859909 cites W2029325590 @default.
- W2763859909 cites W2030184187 @default.
- W2763859909 cites W2031742906 @default.
- W2763859909 cites W2038169129 @default.
- W2763859909 cites W2040546047 @default.
- W2763859909 cites W2047951064 @default.
- W2763859909 cites W2060631637 @default.
- W2763859909 cites W2062308177 @default.
- W2763859909 cites W2064963539 @default.
- W2763859909 cites W2064996887 @default.
- W2763859909 cites W2079512409 @default.
- W2763859909 cites W2087872380 @default.
- W2763859909 cites W2095533841 @default.
- W2763859909 cites W2098508359 @default.
- W2763859909 cites W2108412857 @default.
- W2763859909 cites W2115017507 @default.
- W2763859909 cites W2116709840 @default.
- W2763859909 cites W2117839560 @default.
- W2763859909 cites W2125802963 @default.
- W2763859909 cites W2152482888 @default.
- W2763859909 cites W2159122349 @default.
- W2763859909 cites W2285620773 @default.
- W2763859909 cites W2296416881 @default.
- W2763859909 doi "https://doi.org/10.1038/s41598-017-13831-0" @default.
- W2763859909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5645330" @default.
- W2763859909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29042634" @default.
- W2763859909 hasPublicationYear "2017" @default.
- W2763859909 type Work @default.
- W2763859909 sameAs 2763859909 @default.
- W2763859909 citedByCount "44" @default.
- W2763859909 countsByYear W27638599092018 @default.
- W2763859909 countsByYear W27638599092019 @default.
- W2763859909 countsByYear W27638599092020 @default.
- W2763859909 countsByYear W27638599092021 @default.
- W2763859909 countsByYear W27638599092022 @default.
- W2763859909 countsByYear W27638599092023 @default.
- W2763859909 crossrefType "journal-article" @default.
- W2763859909 hasAuthorship W2763859909A5003363891 @default.
- W2763859909 hasAuthorship W2763859909A5005557542 @default.
- W2763859909 hasAuthorship W2763859909A5024812828 @default.
- W2763859909 hasAuthorship W2763859909A5025313057 @default.
- W2763859909 hasAuthorship W2763859909A5025870220 @default.
- W2763859909 hasAuthorship W2763859909A5033539034 @default.
- W2763859909 hasAuthorship W2763859909A5038926287 @default.
- W2763859909 hasAuthorship W2763859909A5045343267 @default.
- W2763859909 hasAuthorship W2763859909A5048392322 @default.
- W2763859909 hasAuthorship W2763859909A5066503440 @default.
- W2763859909 hasAuthorship W2763859909A5075394738 @default.
- W2763859909 hasAuthorship W2763859909A5079766290 @default.
- W2763859909 hasAuthorship W2763859909A5080228220 @default.