FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763896609> ?p ?o ?g. }

• W2763896609 endingPage "8982" @default.
• W2763896609 startingPage "8959" @default.
• W2763896609 abstract "Particle therapy is especially prone to uncertainties. This issue is usually addressed with uncertainty quantification and minimization techniques based on scenario sampling. For proton therapy, however, it was recently shown that it is also possible to use closed-form computations based on analytical probabilistic modeling (APM) for this purpose. APM yields unique features compared to sampling-based approaches, motivating further research in this context. This paper demonstrates the application of APM for intensity-modulated carbon ion therapy to quantify the influence of setup and range uncertainties on the RBE-weighted dose. In particular, we derive analytical forms for the nonlinear computations of the expectation value and variance of the RBE-weighted dose by propagating linearly correlated Gaussian input uncertainties through a pencil beam dose calculation algorithm. Both exact and approximation formulas are presented for the expectation value and variance of the RBE-weighted dose and are subsequently studied in-depth for a one-dimensional carbon ion spread-out Bragg peak. With V and B being the number of voxels and pencil beams, respectively, the proposed approximations induce only a marginal loss of accuracy while lowering the computational complexity from order [Formula: see text] to [Formula: see text] for the expectation value and from [Formula: see text] to [Formula: see text] for the variance of the RBE-weighted dose. Moreover, we evaluated the approximated calculation of the expectation value and standard deviation of the RBE-weighted dose in combination with a probabilistic effect-based optimization on three patient cases considering carbon ions as radiation modality against sampled references. The resulting global γ-pass rates (2 mm,2%) are [Formula: see text]99.15% for the expectation value and [Formula: see text]94.95% for the standard deviation of the RBE-weighted dose, respectively. We applied the derived analytical model to carbon ion treatment planning, although the concept is in general applicable to other ion species considering a variable RBE." @default.
• W2763896609 created "2017-10-20" @default.
• W2763896609 creator A5022872779 @default.
• W2763896609 creator A5062300903 @default.
• W2763896609 creator A5080329870 @default.
• W2763896609 creator A5089137756 @default.
• W2763896609 date "2017-11-10" @default.
• W2763896609 modified "2023-09-26" @default.
• W2763896609 title "Analytical probabilistic modeling of RBE-weighted dose for ion therapy" @default.
• W2763896609 cites W1967121735 @default.
• W2763896609 cites W1968895120 @default.
• W2763896609 cites W1977322168 @default.
• W2763896609 cites W1983869432 @default.
• W2763896609 cites W1991097740 @default.
• W2763896609 cites W1999189079 @default.
• W2763896609 cites W2001864252 @default.
• W2763896609 cites W2002922254 @default.
• W2763896609 cites W2005348841 @default.
• W2763896609 cites W2011307344 @default.
• W2763896609 cites W2023640892 @default.
• W2763896609 cites W2027438606 @default.
• W2763896609 cites W2029728138 @default.
• W2763896609 cites W2032593689 @default.
• W2763896609 cites W2035384046 @default.
• W2763896609 cites W2039539007 @default.
• W2763896609 cites W2042499995 @default.
• W2763896609 cites W2046069535 @default.
• W2763896609 cites W2047195671 @default.
• W2763896609 cites W2055233491 @default.
• W2763896609 cites W2056634900 @default.
• W2763896609 cites W2057746874 @default.
• W2763896609 cites W2085864921 @default.
• W2763896609 cites W2092515499 @default.
• W2763896609 cites W2094826639 @default.
• W2763896609 cites W2102192086 @default.
• W2763896609 cites W2103101993 @default.
• W2763896609 cites W2105751688 @default.
• W2763896609 cites W2122062060 @default.
• W2763896609 cites W2189922014 @default.
• W2763896609 cites W2212760334 @default.
• W2763896609 cites W2335991213 @default.
• W2763896609 cites W2489755595 @default.
• W2763896609 cites W2529749126 @default.
• W2763896609 cites W2604380817 @default.
• W2763896609 cites W2730653839 @default.
• W2763896609 cites W3104581781 @default.
• W2763896609 cites W3137404195 @default.
• W2763896609 doi "https://doi.org/10.1088/1361-6560/aa915d" @default.
• W2763896609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28980974" @default.
• W2763896609 hasPublicationYear "2017" @default.
• W2763896609 type Work @default.
• W2763896609 sameAs 2763896609 @default.
• W2763896609 citedByCount "9" @default.
• W2763896609 countsByYear W27638966092018 @default.
• W2763896609 countsByYear W27638966092020 @default.
• W2763896609 countsByYear W27638966092021 @default.
• W2763896609 countsByYear W27638966092022 @default.
• W2763896609 crossrefType "journal-article" @default.
• W2763896609 hasAuthorship W2763896609A5022872779 @default.
• W2763896609 hasAuthorship W2763896609A5062300903 @default.
• W2763896609 hasAuthorship W2763896609A5080329870 @default.
• W2763896609 hasAuthorship W2763896609A5089137756 @default.
• W2763896609 hasConcept C105795698 @default.
• W2763896609 hasConcept C11413529 @default.
• W2763896609 hasConcept C11928243 @default.
• W2763896609 hasConcept C120665830 @default.
• W2763896609 hasConcept C121332964 @default.
• W2763896609 hasConcept C134949993 @default.
• W2763896609 hasConcept C151730666 @default.
• W2763896609 hasConcept C153385146 @default.
• W2763896609 hasConcept C163716315 @default.
• W2763896609 hasConcept C185544564 @default.
• W2763896609 hasConcept C22679943 @default.
• W2763896609 hasConcept C2775881188 @default.
• W2763896609 hasConcept C2779244869 @default.
• W2763896609 hasConcept C2779343474 @default.
• W2763896609 hasConcept C2780944729 @default.
• W2763896609 hasConcept C2989005 @default.
• W2763896609 hasConcept C33923547 @default.
• W2763896609 hasConcept C45374587 @default.
• W2763896609 hasConcept C49937458 @default.
• W2763896609 hasConcept C54516573 @default.
• W2763896609 hasConcept C62520636 @default.
• W2763896609 hasConcept C71924100 @default.
• W2763896609 hasConcept C75088862 @default.
• W2763896609 hasConcept C86803240 @default.
• W2763896609 hasConceptScore W2763896609C105795698 @default.
• W2763896609 hasConceptScore W2763896609C11413529 @default.
• W2763896609 hasConceptScore W2763896609C11928243 @default.
• W2763896609 hasConceptScore W2763896609C120665830 @default.
• W2763896609 hasConceptScore W2763896609C121332964 @default.
• W2763896609 hasConceptScore W2763896609C134949993 @default.
• W2763896609 hasConceptScore W2763896609C151730666 @default.
• W2763896609 hasConceptScore W2763896609C153385146 @default.
• W2763896609 hasConceptScore W2763896609C163716315 @default.
• W2763896609 hasConceptScore W2763896609C185544564 @default.
• W2763896609 hasConceptScore W2763896609C22679943 @default.
• W2763896609 hasConceptScore W2763896609C2775881188 @default.

• next