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- W2763948926 abstract "Individuals with amnestic mild cognitive impairment (aMCI) are at a high risk to develop Alzheimer's disease (AD). We compared CSF levels of biomarkers of amyloidosis (Aβ1-42) and neurodegeneration (p-Tau181) in individuals with aMCI and with subjective cognitive impairment (SCI) in order to ascertain diagnostic accuracy and predict the odds ratio associated with aMCI.We collected CSF of individuals clinically diagnosed with aMCI (33) and SCI (12) of a memory clinic of Southern Brazil. Levels of Aβ1-42 and p-Tau181 were measured by immunoenzymatic assay. Participants also underwent neuropsychological testing including the verbal memory test subscore of the Consortium to Establish a Registry for Alzheimer's Disease (VM-CERAD).CSF concentration of Aβ1-42 was significantly lower (p: .007) and p-Tau181/Aβ1-42 ratio higher (p: .014) in aMCI individuals than in SCI. However, isolate p-Tau181 levels were not associated with aMCI (p: .166). There was a statistically significant association between Aβ1-42 and p-Tau181 (R2: 0.177; β: -4.43; p: .017). ROC AUC of CSF Aβ1-42 was 0.768 and of the p-Tau181/Aβ1-42 ratio equals 0.742. Individuals with Aβ1-42 < 823 pg/mL levels were 6.0 times more likely to be diagnosed with aMCI (p: .019), with a 68.9% accuracy. Those with p-Tau181/Aβ1-42 ratio > 0.071 were at 4.6 increased odds to have aMCI (p: .043), with a 64.5% accuracy. VM-CERAD was significantly lower in aMCI than among SCI (p: .041).CSF Aβ1-42, but not p-Tau181, level was significantly associated with aMCI." @default.
- W2763948926 created "2017-10-20" @default.
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- W2763948926 date "2018-01-01" @default.
- W2763948926 modified "2023-10-04" @default.
- W2763948926 title "CSF Aβ1–42, but not p-Tau181, differentiates aMCI from SCI" @default.
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- W2763948926 doi "https://doi.org/10.1016/j.brainres.2017.10.008" @default.
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