Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763952947> ?p ?o ?g. }
- W2763952947 endingPage "251" @default.
- W2763952947 startingPage "242" @default.
- W2763952947 abstract "Mucosal-associated invariant T (MAIT) cells express a semi-invariant Vα7.2+ T cell receptor (TCR) that recognizes ligands from distinct bacterial and fungal species. In neonates, MAIT cells proliferate coincident with gastrointestinal (GI) bacterial colonization. In contrast, under noninflammatory conditions adult MAIT cells remain quiescent because of acquired regulation of TCR signaling. Effects of inflammation and the altered GI microbiota after allogeneic hematopoietic cell transplantation (HCT) on MAIT cell reconstitution have not been described. We conducted an observational study of MAIT cell reconstitution in myeloablative (n = 41) and nonmyeloablative (n = 66) allogeneic HCT recipients and found that despite a rapid and early increase to a plateau at day 30 after HCT, MAIT cell numbers failed to normalize for at least 1 year. Cord blood transplant recipients and those who received post-HCT cyclophosphamide for graft versus host disease (GVHD) prophylaxis had profoundly impaired MAIT cell reconstitution. Sharing of TCRβ gene sequences between MAIT cells isolated from HCT grafts and blood of recipients after HCT showed early MAIT cell reconstitution was due at least in part to proliferation of MAIT cells transferred in the HCT graft. Inflammatory cytokines were required for TCR-dependent MAIT cell proliferation, suggesting that bacterial Vα7.2+ TCR ligands might promote MAIT cell reconstitution after HCT. Robust MAIT cell reconstitution was associated with an increased GI abundance of Blautia spp. MAIT cells suppressed proliferation of conventional T cells consistent with a possible regulatory role. Our data identify modifiable factors impacting MAIT cell reconstitution that could influence the risk of GVHD after HCT." @default.
- W2763952947 created "2017-10-20" @default.
- W2763952947 creator A5017816114 @default.
- W2763952947 creator A5023949296 @default.
- W2763952947 creator A5038572943 @default.
- W2763952947 creator A5041041464 @default.
- W2763952947 creator A5048579207 @default.
- W2763952947 creator A5049889417 @default.
- W2763952947 creator A5055685996 @default.
- W2763952947 creator A5057612788 @default.
- W2763952947 creator A5063888317 @default.
- W2763952947 creator A5077746763 @default.
- W2763952947 creator A5087281332 @default.
- W2763952947 creator A5089990813 @default.
- W2763952947 creator A5090301811 @default.
- W2763952947 creator A5090528267 @default.
- W2763952947 date "2018-02-01" @default.
- W2763952947 modified "2023-10-11" @default.
- W2763952947 title "Graft-Derived Reconstitution of Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation" @default.
- W2763952947 cites W1487816967 @default.
- W2763952947 cites W1492672904 @default.
- W2763952947 cites W1538607209 @default.
- W2763952947 cites W1592407962 @default.
- W2763952947 cites W1795844187 @default.
- W2763952947 cites W1968205810 @default.
- W2763952947 cites W1970518489 @default.
- W2763952947 cites W1979923454 @default.
- W2763952947 cites W1995090169 @default.
- W2763952947 cites W2008210335 @default.
- W2763952947 cites W2008617601 @default.
- W2763952947 cites W2009075017 @default.
- W2763952947 cites W2022111190 @default.
- W2763952947 cites W2027160668 @default.
- W2763952947 cites W2030817385 @default.
- W2763952947 cites W2035681497 @default.
- W2763952947 cites W2036378796 @default.
- W2763952947 cites W2049739427 @default.
- W2763952947 cites W2050014694 @default.
- W2763952947 cites W2051129065 @default.
- W2763952947 cites W2065252029 @default.
- W2763952947 cites W2073247934 @default.
- W2763952947 cites W2074640340 @default.
- W2763952947 cites W2076524314 @default.
- W2763952947 cites W2091247150 @default.
- W2763952947 cites W2093443553 @default.
- W2763952947 cites W2098836821 @default.
- W2763952947 cites W2117410945 @default.
- W2763952947 cites W2119718776 @default.
- W2763952947 cites W2122096954 @default.
- W2763952947 cites W2124139886 @default.
- W2763952947 cites W2125230147 @default.
- W2763952947 cites W2133863401 @default.
- W2763952947 cites W2136432779 @default.
- W2763952947 cites W2143917136 @default.
- W2763952947 cites W2145493091 @default.
- W2763952947 cites W2160608319 @default.
- W2763952947 cites W2162051526 @default.
- W2763952947 cites W2314998678 @default.
- W2763952947 cites W2411592636 @default.
- W2763952947 doi "https://doi.org/10.1016/j.bbmt.2017.10.003" @default.
- W2763952947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5806215" @default.
- W2763952947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29024803" @default.
- W2763952947 hasPublicationYear "2018" @default.
- W2763952947 type Work @default.
- W2763952947 sameAs 2763952947 @default.
- W2763952947 citedByCount "65" @default.
- W2763952947 countsByYear W27639529472017 @default.
- W2763952947 countsByYear W27639529472018 @default.
- W2763952947 countsByYear W27639529472019 @default.
- W2763952947 countsByYear W27639529472020 @default.
- W2763952947 countsByYear W27639529472021 @default.
- W2763952947 countsByYear W27639529472022 @default.
- W2763952947 countsByYear W27639529472023 @default.
- W2763952947 crossrefType "journal-article" @default.
- W2763952947 hasAuthorship W2763952947A5017816114 @default.
- W2763952947 hasAuthorship W2763952947A5023949296 @default.
- W2763952947 hasAuthorship W2763952947A5038572943 @default.
- W2763952947 hasAuthorship W2763952947A5041041464 @default.
- W2763952947 hasAuthorship W2763952947A5048579207 @default.
- W2763952947 hasAuthorship W2763952947A5049889417 @default.
- W2763952947 hasAuthorship W2763952947A5055685996 @default.
- W2763952947 hasAuthorship W2763952947A5057612788 @default.
- W2763952947 hasAuthorship W2763952947A5063888317 @default.
- W2763952947 hasAuthorship W2763952947A5077746763 @default.
- W2763952947 hasAuthorship W2763952947A5087281332 @default.
- W2763952947 hasAuthorship W2763952947A5089990813 @default.
- W2763952947 hasAuthorship W2763952947A5090301811 @default.
- W2763952947 hasAuthorship W2763952947A5090528267 @default.
- W2763952947 hasBestOaLocation W27639529471 @default.
- W2763952947 hasConcept C109159458 @default.
- W2763952947 hasConcept C126322002 @default.
- W2763952947 hasConcept C1491633281 @default.
- W2763952947 hasConcept C19317047 @default.
- W2763952947 hasConcept C203014093 @default.
- W2763952947 hasConcept C2776090121 @default.
- W2763952947 hasConcept C2777408962 @default.
- W2763952947 hasConcept C2779972918 @default.
- W2763952947 hasConcept C28328180 @default.