FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2763997960> ?p ?o ?g. }

• W2763997960 abstract "Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and maturation of thymocytes whose TCRs display intermediate affinity to self pMHCs for effective immunity, but whether transcriptional regulation helps conserve positively selected thymocytes from being purged by negative selection remains unclear. Here we show that the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells causes excessive negative selection to reduce mature thymocyte numbers. Mechanistically, NCoR1 protects positively selected thymocytes from negative selection by suppressing Bim expression. Our study demonstrates a critical function of NCoR1 in coordinated positive and negative selections in the thymus.Thymocytes are screened by two processes, termed positive and negative selections, which are permissive only for immature thymocytes with intermediate avidity to the selecting ligands. Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival." @default.
• W2763997960 created "2017-10-20" @default.
• W2763997960 creator A5003154600 @default.
• W2763997960 creator A5008514827 @default.
• W2763997960 creator A5009922794 @default.
• W2763997960 creator A5014641931 @default.
• W2763997960 creator A5033988281 @default.
• W2763997960 creator A5038084893 @default.
• W2763997960 creator A5042467158 @default.
• W2763997960 creator A5045494666 @default.
• W2763997960 creator A5049211921 @default.
• W2763997960 creator A5049828619 @default.
• W2763997960 creator A5056064034 @default.
• W2763997960 creator A5065904019 @default.
• W2763997960 creator A5068690410 @default.
• W2763997960 creator A5082924617 @default.
• W2763997960 creator A5087519016 @default.
• W2763997960 creator A5087598197 @default.
• W2763997960 creator A5088366112 @default.
• W2763997960 creator A5071454160 @default.
• W2763997960 date "2017-10-16" @default.
• W2763997960 modified "2023-10-10" @default.
• W2763997960 title "NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection" @default.
• W2763997960 cites W1151272222 @default.
• W2763997960 cites W1595915388 @default.
• W2763997960 cites W1761323037 @default.
• W2763997960 cites W1896292714 @default.
• W2763997960 cites W1964042890 @default.
• W2763997960 cites W1967609586 @default.
• W2763997960 cites W1968604097 @default.
• W2763997960 cites W1978527149 @default.
• W2763997960 cites W1978719878 @default.
• W2763997960 cites W1980050753 @default.
• W2763997960 cites W1995540562 @default.
• W2763997960 cites W1998854301 @default.
• W2763997960 cites W2002030208 @default.
• W2763997960 cites W2004502371 @default.
• W2763997960 cites W2019626501 @default.
• W2763997960 cites W2035253030 @default.
• W2763997960 cites W2035634881 @default.
• W2763997960 cites W2039103537 @default.
• W2763997960 cites W2043354458 @default.
• W2763997960 cites W2054444927 @default.
• W2763997960 cites W2054835199 @default.
• W2763997960 cites W2056597149 @default.
• W2763997960 cites W2079650395 @default.
• W2763997960 cites W2081770315 @default.
• W2763997960 cites W2083148444 @default.
• W2763997960 cites W2083717367 @default.
• W2763997960 cites W2083725451 @default.
• W2763997960 cites W2099807030 @default.
• W2763997960 cites W2123774383 @default.
• W2763997960 cites W2128106363 @default.
• W2763997960 cites W2131158808 @default.
• W2763997960 cites W2136879986 @default.
• W2763997960 cites W2139472488 @default.
• W2763997960 cites W2139595023 @default.
• W2763997960 cites W2142878395 @default.
• W2763997960 cites W2152762466 @default.
• W2763997960 cites W2156268135 @default.
• W2763997960 cites W2160419609 @default.
• W2763997960 cites W2211191368 @default.
• W2763997960 cites W2615548860 @default.
• W2763997960 cites W4211059834 @default.
• W2763997960 doi "https://doi.org/10.1038/s41467-017-00931-8" @default.
• W2763997960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5643384" @default.
• W2763997960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29038463" @default.
• W2763997960 hasPublicationYear "2017" @default.
• W2763997960 type Work @default.
• W2763997960 sameAs 2763997960 @default.
• W2763997960 citedByCount "13" @default.
• W2763997960 countsByYear W27639979602018 @default.
• W2763997960 countsByYear W27639979602019 @default.
• W2763997960 countsByYear W27639979602020 @default.
• W2763997960 countsByYear W27639979602022 @default.
• W2763997960 crossrefType "journal-article" @default.
• W2763997960 hasAuthorship W2763997960A5003154600 @default.
• W2763997960 hasAuthorship W2763997960A5008514827 @default.
• W2763997960 hasAuthorship W2763997960A5009922794 @default.
• W2763997960 hasAuthorship W2763997960A5014641931 @default.
• W2763997960 hasAuthorship W2763997960A5033988281 @default.
• W2763997960 hasAuthorship W2763997960A5038084893 @default.
• W2763997960 hasAuthorship W2763997960A5042467158 @default.
• W2763997960 hasAuthorship W2763997960A5045494666 @default.
• W2763997960 hasAuthorship W2763997960A5049211921 @default.
• W2763997960 hasAuthorship W2763997960A5049828619 @default.
• W2763997960 hasAuthorship W2763997960A5056064034 @default.
• W2763997960 hasAuthorship W2763997960A5065904019 @default.
• W2763997960 hasAuthorship W2763997960A5068690410 @default.
• W2763997960 hasAuthorship W2763997960A5071454160 @default.
• W2763997960 hasAuthorship W2763997960A5082924617 @default.
• W2763997960 hasAuthorship W2763997960A5087519016 @default.
• W2763997960 hasAuthorship W2763997960A5087598197 @default.
• W2763997960 hasAuthorship W2763997960A5088366112 @default.
• W2763997960 hasBestOaLocation W27639979601 @default.
• W2763997960 hasConcept C104317684 @default.
• W2763997960 hasConcept C109159458 @default.
• W2763997960 hasConcept C14036430 @default.
• W2763997960 hasConcept C141231307 @default.
• W2763997960 hasConcept C167672396 @default.

• next