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• W2764037605 abstract "Burst firing in medial substantia nigra (mSN) dopamine (DA) neurons has been selectively linked to novelty-induced exploration behavior in mice. Burst firing in mSN DA neurons, in contrast to lateral SN DA neurons, requires functional ATP-sensitive potassium (K-ATP) channels both in vitro and in vivo. However, the precise role of K-ATP channels in promoting burst firing is unknown. We show experimentally that L-type calcium channel activity in mSN DA neurons enhances open probability of K-ATP channels. We then generate a mathematical model to study the role of Ca 2+ dynamics driving K-ATP channel function in mSN DA neurons during bursting. In our model, Ca 2+ influx leads to local accumulation of ADP due to Ca-ATPase activity, which in turn activates K-ATP channels. If K-ATP channel activation reaches levels sufficient to terminate spiking, rhythmic bursting occurs. The model explains the experimental observation that, in vitro, coapplication of NMDA and a selective K-ATP channel opener, NN414, is required to elicit bursting as follows. Simulated NMDA receptor activation increases the firing rate and the rate of Ca 2+ influx, which increases the activation of K-ATP. The model suggests that additional sources of hyperpolarization, such as GABAergic synaptic input, are recruited in vivo for burst termination or rebound burst discharge. The model predicts that NN414 increases the sensitivity of the K-ATP channel to ADP, promoting burst firing in vitro, and that that high levels of Ca 2+ buffering, as might be expected in the calbindin-positive SN DA neuron subpopulation, promote rhythmic bursting pattern, consistent with experimental observations in vivo. NEW & NOTEWORTHY Recently identified distinct subpopulations of midbrain dopamine neurons exhibit differences in their two primary activity patterns in vivo: tonic (single spike) firing and phasic bursting. This study elucidates the biophysical basis of bursts specific to dopamine neurons in the medial substantia nigra, enabled by ATP-sensitive K + channels and necessary for novelty-induced exploration. A better understanding of how dopaminergic signaling differs between subpopulations may lead to therapeutic strategies selectively targeted to specific subpopulations." @default.
• W2764037605 created "2017-10-20" @default.
• W2764037605 creator A5056283225 @default.
• W2764037605 creator A5057798287 @default.
• W2764037605 creator A5063543349 @default.
• W2764037605 creator A5083854721 @default.
• W2764037605 date "2018-01-01" @default.
• W2764037605 modified "2023-10-15" @default.
• W2764037605 title "Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study" @default.
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• W2764037605 doi "https://doi.org/10.1152/jn.00351.2017" @default.
• W2764037605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5866464" @default.
• W2764037605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28978764" @default.
• W2764037605 hasPublicationYear "2018" @default.
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